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Breathe Easy: Study Shows Probiotics May Freshen Breath and Kick Bad Breath to the Curb

Written by Andrew Le, MD

UpdatedMarch 22, 2024

A recent study aimed to uncover the effectiveness of probiotics in treating halitosis, otherwise known as bad breath. Halitosis is a condition that can lead to significant psychological distress and social embarrassment for those suffering from it.

To begin, let's define halitosis and explore how widespread this condition is. Halitosis is characterized by an unpleasant odor coming from the mouth, which can vary in severity from person to person. It is one of the top three reasons why people seek dental care, just behind cavities and gum disease. Furthermore, an epidemiological study found that about 27.5% of the Chinese population suffers from halitosis, reflecting how common the issue is worldwide.

Traditionally, halitosis is treated through methods such as mouthwashes, tongue scraping, and even antibiotics. However, these treatments can be uncomfortable, are not always long-lasting, and sometimes come with side effects. This has led to interest in alternative therapies, such as probiotics, that might offer a more user-friendly approach to managing this condition.

The team of researchers that investigated this topic, including Nengwen Huang, Jinjin Li, Xianghe Qiao, Yongzhi Wu, Yunkun Liu, Chenzhou Wu, and Longjiang Li, conducted a systematic review and meta-analysis to assess the impact of probiotics on halitosis. Their study looked at the effects of these living microorganisms when administered in specific amounts. Probiotics, which are most known for their digestive health benefits, have the potential to balance the oral microbiota (the collection of microorganisms living in the mouth) and in doing so, reduce the levels of volatile sulfur compounds (VSC), which are the main contributors to the foul smell associated with halitosis.

The researchers' approach was comprehensive, including randomized controlled trials that compared the effects of probiotics with a placebo. Primary outcomes of interest were organoleptic scores (OLP) and volatile sulfur compound (VSC) levels, which provide a measure of the severity of halitosis. They also looked at secondary outcomes like tongue coating scores (TCS) and plaque index (PI).

The findings of this study indicated that probiotics could reduce OLP scores and VSC levels in the short term, which essentially means they were effective at reducing bad breath quickly. The analysis showed that this beneficial effect of probiotics could be observed for up to four weeks. This suggests that probiotics like Lactobacillus salivarius, Lactobacillus reuteri, Streptococcus salivarius, and Weissella cibaria could offer a legitimate solution for managing halitosis.

Despite the effectiveness of probiotics in the short term, the study had limitations, including a small patient sample size and varying outcomes reported in the different studies included in the analysis. Nevertheless, with no significant evidence of publication bias and a stable pooled estimate confirmed through a leave-one-out analysis, the results appear promising.

In conclusion, the researchers suggest that probiotics have the potential to offer relief from halitosis when used in the short term. The possible benefit of probiotics extends beyond their well-known effects on gut health to potentially improving oral health, a domain often fraught with chronic conditions and limited by side effects of traditional treatments. This study opens up new avenues for treating halitosis, which could be life-changing for many individuals. However, it also highlights the need for further research with larger sample sizes and more homogeneous reporting of outcomes to definitively confirm the effectiveness and safety of probiotics in the long-term management of halitosis.

References

Huang N, Li J, Qiao X, et alEfficacy of probiotics in the management of halitosis: a systematic review and meta-analysisBMJ Open 2022;12:e060753. doi: 10.1136/bmjopen-2022-060753