Cosentyx (Secukinumab): Uses, Dosage, Side Effects, Warnings

Cosentyx (Secukinumab) is a prescription medication used to treat various autoimmune conditions such as psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. This medication belongs to a class of drugs called interleukin inhibitors, which work by blocking the activity of interleukin-17A, a protein that plays a role in inflammation and immune system response.

Before taking Cosentyx, it is important to understand its uses, dosage, side effects, and warnings. Your healthcare provider will determine the appropriate dosage and administration schedule based on your medical condition, response to treatment, and other factors. It is important to follow the instructions carefully and report any side effects or concerns to your healthcare provider.

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Key Takeaways

• Cosentyx is a prescription medication used to treat various autoimmune conditions such as psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis.
• Before taking Cosentyx, it is important to understand its uses, dosage, side effects, and warnings.
• Your healthcare provider will determine the appropriate dosage and administration schedule based on your medical condition, response to treatment, and other factors.

What is Cosentyx (Secukinumab)?

Cosentyx (Secukinumab) is a monoclonal antibody and an immunosuppressant drug that is used to treat several autoimmune conditions. It is a biologic medication that is designed to block the activity of interleukin-17A (IL-17A), a protein that is involved in inflammation and the development of autoimmune diseases.

Cosentyx is primarily used to treat moderate to severe plaque psoriasis in patients who are candidates for systemic therapy or phototherapy. It is also used to treat psoriatic arthritis, ankylosing spondylitis, enthesitis-related arthritis, and non-radiographic axial spondyloarthritis.

The active ingredient in Cosentyx is secukinumab, which is a human monoclonal antibody that targets IL-17A. By blocking the activity of this protein, Cosentyx reduces inflammation, pain, swelling, and skin symptoms that patients may experience.

Cosentyx is administered by injection, either by a healthcare professional or by the patient themselves after proper training. The dosage and frequency of injections may vary depending on the condition being treated and the patient's individual response to the medication.

As with all medications, there are potential side effects associated with Cosentyx. Common side effects may include sore throat and nose, diarrhea, and upper respiratory tract infections. Patients should talk to their healthcare provider about any concerns or questions they may have about the medication.

Uses of Cosentyx

Cosentyx (Secukinumab) is a medication used to treat various autoimmune conditions, including plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, enthesitis-related arthritis, and non-radiographic axial spondyloarthritis. It is a human interleukin-17A antagonist that works by blocking the action of a protein in the body that causes inflammation.

Cosentyx is typically used for patients who have not responded to or cannot tolerate other treatments such as topical medications or phototherapy. It is available as an injection and is administered by a healthcare professional.

In clinical trials, Cosentyx has been shown to be effective in reducing the severity of symptoms associated with these conditions. It can improve skin symptoms in patients with moderate to severe plaque psoriasis, reduce joint pain and swelling in patients with psoriatic arthritis, and improve spinal mobility in patients with ankylosing spondylitis.

Cosentyx has also shown promise in treating inflammatory bowel disease, including ulcerative colitis. However, it is important to note that this medication is not currently approved by the FDA for this use.

Overall, Cosentyx is a valuable treatment option for patients with autoimmune conditions who have not responded to other therapies. It is important to discuss the risks and benefits of this medication with a healthcare professional to determine if it is the right choice for you.

Dosage and Administration

Cosentyx (Secukinumab) is available as lyophilized powder for reconstitution, solution for injection, single-dose Sensoready pen, and single-dose prefilled syringes. It is administered by subcutaneous injection.

The recommended dosage for adults with moderate to severe plaque psoriasis is 300 mg by subcutaneous injection at Weeks 0, 1, 2, 3, and 4, followed by 300 mg every 4 weeks. For some patients, a dose of 150 mg may be acceptable.

For adult patients with active psoriatic arthritis, the recommended dosage is 300 mg by subcutaneous injection at Weeks 0, 1, 2, 3, and 4, followed by 300 mg every 4 weeks.

For adult patients with ankylosing spondylitis, the recommended dosage is 150 mg or 300 mg by subcutaneous injection every 4 weeks.

The recommended dose for pediatric patients (ages 6 years and older) with moderate to severe plaque psoriasis is based on body weight. For patients weighing less than 50 kg, the recommended dose is 75 mg every 4 weeks. For patients weighing 50 kg or more, the recommended dose is 150 mg every 4 weeks.

It is important to follow the prescription label instructions for the correct dosage and administration of Cosentyx. Patients should be advised to inject Cosentyx into the thigh or abdomen, and to rotate injection sites with each dose. If a dose is missed, it should be administered as soon as possible. However, if the missed dose is remembered less than 7 days before the next scheduled dose, the missed dose should be skipped.

In case of an overdose, patients should seek immediate medical attention. Symptoms of an overdose may include severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

Storage and Handling

Proper storage and handling of Cosentyx (Secukinumab) is essential to ensure its effectiveness and safety. Here are some guidelines to follow:

• Cosentyx (Secukinumab) should be stored in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).
• The injection pen should be kept in its original carton to protect it from light.
• If necessary, the solution can be stored at room temperature (up to 25°C or 77°F) for a maximum of 14 days. After this time, any unused solution should be discarded.
• The lyophilized powder should be stored in its original carton in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).
• The sterile water for injection should be stored at room temperature (up to 25°C or 77°F).
• Do not freeze Cosentyx (Secukinumab) or expose it to heat.
• Do not shake the injection pen or vial.
• Before use, inspect the solution for any discoloration or particles. If either is present, do not use the solution.
• Do not use Cosentyx (Secukinumab) if it has expired.
• Keep Cosentyx (Secukinumab) out of reach of children and pets.

By following these guidelines, you can ensure that Cosentyx (Secukinumab) remains effective and safe for use. If you have any questions or concerns about storage and handling, speak with your healthcare provider or pharmacist.

Side Effects and Warnings

As with any medication, Cosentyx (Secukinumab) can cause side effects. Some of the common side effects of Cosentyx include:

• Cold symptoms such as a runny or stuffy nose, sneezing, and sore throat.
• Pain or swelling at the injection site.
• Diarrhea.

If you experience any of these side effects, you should contact your doctor. Your doctor may be able to suggest ways to manage these side effects or adjust your dosage to reduce their severity.

In addition to these common side effects, Cosentyx can also cause serious side effects. Call your doctor right away if you experience any of the following:

• Signs of infection such as fever, chills, sweats, muscle aches, skin sores, stomach pain, diarrhea, burning when you urinate, weight loss, cough, shortness of breath, or a cough with red or pink mucus.
• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
• Allergic reactions such as hives, rash, itching, swelling of the face, lips, tongue, or throat, or difficulty breathing or swallowing.

Cosentyx may also interact with other medications, so it's important to tell your doctor about all the medications you're taking, including prescription drugs, over-the-counter medications, and herbal supplements.

Before starting treatment with Cosentyx, tell your doctor if you have any of the following conditions:

• Tuberculosis or have been in close contact with someone who has tuberculosis.
• An allergy to latex.
• Recently received a vaccine or plan to receive a vaccine.
• An infection that won't go away or keeps coming back.
• A history of a serious allergic reaction to any medication.

If you experience any of the serious side effects or have any of the conditions listed above, your doctor may advise you to stop taking Cosentyx or adjust your dosage. It's important to follow your doctor's instructions carefully to ensure your safety and well-being.

Interactions with Other Drugs

When taking Cosentyx (Secukinumab), it is important to be aware of potential interactions with other drugs, including vaccines. Inform your healthcare provider of all medications and supplements you are currently taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements.

Cosentyx may interact with other immunosuppressants, such as Taltz and Humira. The concurrent use of these drugs may increase the risk of infections. Therefore, caution should be exercised when using these drugs together.

Additionally, live vaccines should not be administered while taking Cosentyx, as they may cause infections. It is recommended to complete all necessary vaccinations before starting treatment with Cosentyx.

It is important to note that this is not an exhaustive list of all possible drug interactions with Cosentyx. Always consult with your healthcare provider before starting or stopping any medications while taking Cosentyx.

Special Considerations

When using Cosentyx (Secukinumab), there are several special considerations that healthcare providers and patients should keep in mind.

Pregnancy and Breastfeeding

It is not known whether Cosentyx can harm an unborn baby. Pregnant women should only use this medication if absolutely necessary and under the supervision of a healthcare provider. Similarly, it is not known whether Cosentyx can pass into breast milk or harm a nursing baby. Women who are breastfeeding should speak with their healthcare provider before using this medication.

Children

The safety and effectiveness of Cosentyx in children under 18 years of age have not been established. Therefore, this medication is not recommended for use in pediatric patients.

Tuberculosis (TB)

Cosentyx can increase the risk of tuberculosis (TB) infection. Healthcare providers should screen patients for TB before starting treatment with Cosentyx. Patients who have latent TB should be treated for TB before starting Cosentyx. Patients who develop signs of TB during treatment with Cosentyx should be monitored closely and treated for TB as necessary.

Allergy

Patients who are allergic to Cosentyx or any of its ingredients should not use this medication. Signs of an allergic reaction include difficulty breathing, hives, and swelling of the face, lips, tongue, or throat. If an allergic reaction occurs, patients should seek immediate medical attention.

Other Considerations

Patients who experience symptoms such as chills, weight gain, or weight loss during treatment with Cosentyx should inform their healthcare provider. Additionally, patients should inform their healthcare provider if they are taking any supplements or generic medications. Healthcare providers and pharmacists should be aware of the potential side effects of Cosentyx and monitor patients closely for any adverse reactions.

Cosentyx Vs. Other Treatments

When it comes to treating autoimmune conditions like plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, enthesitis-related arthritis, and non-radiographic axial spondyloarthritis, there are several treatment options available. Here, we will compare Cosentyx to some of the other treatments available in the market.

Cosentyx Vs. Taltz

Taltz (ixekizumab) is another medication that is used to treat plaque psoriasis and psoriatic arthritis. While both drugs are effective in treating these conditions, there are some differences between the two.

Cosentyx is a monoclonal antibody that targets a specific protein called interleukin-17A (IL-17A), while Taltz targets another protein called interleukin-17 (IL-17). Cosentyx has been found to be more effective than Taltz in treating plaque psoriasis, but Taltz may be more effective in treating psoriatic arthritis.

Cosentyx Vs. Humira

Humira (adalimumab) is a systemic therapy that is used to treat several autoimmune conditions, including plaque psoriasis and psoriatic arthritis. While both Cosentyx and Humira are effective in treating these conditions, there are some differences between the two.

Cosentyx is a newer drug and has been found to be more effective than Humira in treating plaque psoriasis. However, Humira may be more effective in treating psoriatic arthritis.

Cosentyx Vs. Systemic Therapy

Systemic therapy is a broad term that refers to any medication that is taken orally or injected and travels throughout the body to treat a condition. Cosentyx is a type of systemic therapy that is injected into the skin.

Compared to other systemic therapies, Cosentyx has been found to be more effective in treating plaque psoriasis and psoriatic arthritis. It may also have fewer side effects than some other systemic therapies.

Cosentyx Vs. Phototherapy

Phototherapy is a type of treatment that uses ultraviolet light to treat skin conditions like psoriasis. While phototherapy can be effective in treating psoriasis, it may not be as effective as Cosentyx in treating psoriatic arthritis.

Overall, Cosentyx is a highly effective treatment option for autoimmune conditions like plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, enthesitis-related arthritis, and non-radiographic axial spondyloarthritis. However, the choice of treatment depends on several factors, including the severity of the condition, the patient's medical history, and other factors.

Additional Information

Cosentyx (Secukinumab) is an immunosuppressant medication that is used to treat various autoimmune conditions, including plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, enthesitis-related arthritis, and non-radiographic axial spondyloarthritis. It works by reducing the effects of a chemical substance in the body that can cause inflammation.

It is important to note that Cosentyx should only be used under the supervision of a healthcare professional, as it can cause serious side effects. The FDA has issued warnings about the potential for serious infections, including tuberculosis and herpes, as well as the risk of cancer.

Common side effects of Cosentyx include sore throat, runny or stuffy nose, and cough. These side effects are usually mild and go away on their own, but patients should contact their healthcare provider if they become severe or persistent.

Cosentyx is administered by injection, either by a healthcare professional or by the patient themselves after proper training. The medication comes in a prefilled syringe or autoinjector, and should be stored in the refrigerator until use.

Cosentyx contains histidine hydrochloride monohydrate, polysorbate 80, and trehalose dihydrate, which may cause allergic reactions in some patients. Patients should inform their healthcare provider if they have a history of allergies or allergic reactions.

Cosentyx is not recommended for use in children or adolescents under the age of 18, and should be used with caution in elderly patients and those with a weakened immune system.

Overall, Cosentyx is a powerful medication that can provide relief for patients suffering from autoimmune conditions. However, it should be used with caution and under the supervision of a healthcare professional, as it can cause serious side effects.

Frequently Asked Questions

1. What are the common side effects of Cosentyx?

The common side effects of Cosentyx include cold symptoms, diarrhea, and upper respiratory tract infections.

2. What are the rare side effects of Cosentyx?

The rare side effects of Cosentyx include allergic reactions, serious infections, and depression.

3. Are there any long-term side effects of using Cosentyx?

The long-term side effects of using Cosentyx are not yet known. However, it is important to discuss any concerns with your healthcare provider.

4. What precautions should be taken while using Cosentyx?

Before taking Cosentyx, inform your healthcare provider if you have a history of infections, tuberculosis, or if you are pregnant or breastfeeding. It is also important to inform your healthcare provider of any medications you are taking.

5. How long does Cosentyx stay in the system after stopping the treatment?

The elimination half-life of Cosentyx is approximately 28 days. However, the duration of the drug's effects may vary depending on the individual.

6. What should I do if I experience any side effects while using Cosentyx?

If you experience any side effects while using Cosentyx, contact your healthcare provider immediately. It is important to report any adverse reactions to the FDA's MedWatch program.