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Unlocking the Stroke Puzzle: How Migraines and Unconventional Risks Rewrite Young Adult Health Concerns

Written by Andrew Le, MD

UpdatedApril 10, 2024

A recently published medical journal has provided valuable insights into the risk factors linked to stroke occurrence among younger adults. Based on their research, it appears that both traditional and nontraditional risk factors significantly impact stroke risk across all age groups, particularly in adults under the age of 35.

The study at the core of these findings was a retrospective case-control investigation that used data from Colorado's All Payer Claims Database, covering the period from 2012 to 2019. Researchers identified cases of stroke in adults between the ages of 18 and 55 and matched them to controls that were free of strokes. Matching was based on sex, age (within two years), insurance type, and the period before the stroke occurred. By analyzing both traditional risk factors, such as high blood pressure and diabetes, and nontraditional ones like migraines and thrombophilia, they employed statistical methods to understand the association of these factors with stroke risk.

The findings showed that each additional risk factor, be it traditional or nontraditional, was linked to a heightened risk of stroke across different sex and age categories. In the younger cohort—adults between 18 to 34—the study discovered that strokes were more strongly associated with nontraditional risk factors (with a population attributable risk of 31.4% in men and an even more significant 42.7% in women) as compared to traditional risk factors (25.3% in men and 33.3% in women). As people aged, the influence of nontraditional risk factors lessened slightly, with men and women aged 45 to 55 seeing a contribution of 19.4% and 27.9% respectively from these factors.

In the middle age category of 35 to 44 years, traditional risk factors seemed to reach their peak influence on stroke risk, with figures reaching 32.8% for men and 39.7% for women. High blood pressure emerged as the most impactful traditional risk factor, particularly in the older age groups mentioned earlier, while migraines were highlighted as the most significant nontraditional risk factor, particularly among the youngest adults studied (with a population attributable risk of 20.1% for men and 34.5% for women aged 18–35).

In conclusion, the study underscores the importance of considering both traditional and nontraditional risk factors when looking at stroke risk in young adults. Interestingly, nontraditional risk factors seem to play a more prominent role in this age group than was previously understood.

For a detailed analysis and understanding of the study's implications, please refer to the comprehensive academic report.

References

Leppert MH, Poisson SN, Scarbro S, Suresh K, Lisabeth LD, Putaala J, Schwamm LH, Daugherty SL, Bradley CJ, Burke JF, Ho PM. Association of Traditional and Nontraditional Risk Factors in the Development of Strokes Among Young Adults by Sex and Age Group: A Retrospective Case-Control Study. Circ Cardiovasc Qual Outcomes. 2024 Mar 26:e010307. doi: 10.1161/CIRCOUTCOMES.123.010307. Epub ahead of print. PMID: 38529631.