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Top 13 Best Cold Sore Treatments

UpdatedFebruary 29, 2024

Cold sores are a common and often painful condition caused by the herpes simplex virus. They can appear on or around the lips and are highly contagious. There are many different treatments available for cold sores, including over-the-counter creams, prescription medications, and natural remedies. However, finding the best cold sore treatment can be challenging, as there are so many options to choose from.

When looking for the best cold sore treatment, it's important to consider factors such as effectiveness, ease of use, and cost. Some treatments may work better for certain individuals than others, so it's essential to find the right one for your specific needs. Additionally, it's crucial to start treatment as soon as possible after symptoms appear to prevent the cold sore from worsening.

After researching and testing various cold sore treatments, we have identified the most effective options for treating cold sores quickly and safely. In this article, we will discuss the best cold sore treatments on the market, including their pros and cons, and provide recommendations for which products to try.

Top 3 Best Cold Sore Treatments

  1. Mederma Cold Sore Discreet Healing Patch
  2. Abreva 10 Percent Docosanol Cold Sore Treatment
  3. Herpecin-L Pain Relief Triple Action with Lidocaine Cold Sore and Fever Blister Treatment

If you've ever experienced a cold sore, you know how uncomfortable and unsightly they can be. That's why we've put together a list of the best cold sore treatments available on Amazon. We've researched and tested these products to bring you the most effective options for treating and preventing cold sores. Whether you're looking for a cream, gel, or patch, we've got you covered. Check out our top picks below.

Mederma Cold Sore Discreet Healing Patch

The Editor's Choice

Discover the game-changing Mederma Cold Sore Healing Patch, our top pick for conquering cold sores. Effortless application, 12-hour staying power, and a discreet design that seamlessly vanishes beneath makeup. Don't miss out in experience soothing relief and rapid recovery with this must-have solution.

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We highly recommend the Mederma Cold Sore Discreet Healing Patch for anyone who suffers from cold sores. This product is a game-changer when it comes to treating cold sores.

Pros

  • Fast healing ultra-thin Hydrocolloid Gel provides a moist environment to help: relieve pain, reduce the blistering and prevent scabbing.
  • Discreet design ensures that the patch blends in with the skin and can be easily covered with makeup.
  • Easy apllication - The patch is easy to apply and stays in place for up to 12 hours.

Cons

  • The patch may not stick well if the skin is oily or wet.
  • The patch may not be suitable for people with sensitive skin.
  • The patch may not be suitable for people with large cold sores.

The Mederma Cold Sore Discreet Healing Patch is one of the best cold sore treatments we have ever used. The patch is easy to apply and stays in place for up to 12 hours. The discreet design ensures that the patch blends in with the skin and can be easily covered with makeup. The ultra-thin Hydrocolloid Gel provides a moist environment to help relieve pain, reduce the blistering and prevent scabbing.

One of the downsides of the patch is that it may not stick well if the skin is oily or wet. Additionally, the patch may not be suitable for people with sensitive skin or large cold sores. However, overall, we highly recommend the Mederma Cold Sore Discreet Healing Patch to anyone who suffers from cold sores. It is a fantastic product that provides fast and effective relief.

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If you're looking for a fast and effective cold sore treatment, Abreva 10 Percent Docosanol Cold Sore Treatment is definitely worth considering.

Pros

  • Clinically proven to shorten the duration of cold sore symptoms
  • Portable and easy to use on the go
  • Dermatologist recommended

Cons

  • May not work for everyone
  • Expensive compared to other cold sore treatments
  • Can cause dryness and flaking of the skin

We've tried a lot of different cold sore treatments over the years, but Abreva is definitely one of the best. The 10 percent docosanol cream penetrates deep into the skin to tackle cold sores at their source, and it's been clinically proven to shorten the duration of tingling, pain, burning, and itching associated with cold sores.

One of the things we love about Abreva is that it's packaged in a convenient tube, so you can easily take it with you wherever you go. Whether you're traveling, at work, or out running errands, you can quickly and easily apply Abreva to your cold sore to help speed up the healing process.

Of course, like any cold sore treatment, Abreva may not work for everyone. Some people may find that it doesn't shorten the duration of their cold sore or that it causes dryness and flaking of the skin. Additionally, Abreva is more expensive than many other cold sore treatments on the market, so it may not be the best choice if you're on a tight budget.

Overall, we would definitely recommend Abreva 10 Percent Docosanol Cold Sore Treatment to anyone looking for a fast and effective way to treat cold sores. With its clinically proven formula and convenient packaging, it's definitely one of the best options out there.

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If you're looking for a targeted spot treatment for cold sores and fever blisters, then Herpecin-L Pain Relief Triple Action with Lidocaine is a great option. It instantly numbs cold sore and fever blister pain & itch, protects against infection, and helps prevent cracking.

Pros

  • The maximum strength lidocaine targets and numbs cold sore pain & itch right at the source and starts working on contact.
  • A soothing skin protectant helps prevent painful cracking and re-opening while keeping the cold sore moisturized.
  • Maximum strength antiseptic helps keep the cold sore from getting infected.

Cons

  • The product goes on clear, which can make it difficult to see where it has been applied.
  • The tube is small, which means it may not last very long if you have frequent cold sores.
  • The product may be more expensive than other cold sore treatments on the market.

In our experience, Herpecin-L Pain Relief Triple Action with Lidocaine is a great option for those looking for a targeted spot treatment for cold sores and fever blisters. The maximum strength lidocaine works quickly to numb pain and itch, while the skin protectant and antiseptic ingredients work to prevent cracking and infection. However, the product does go on clear, which can make it difficult to see where it has been applied. Additionally, the tube is small and may not last very long if you have frequent cold sores. Finally, the product may be more expensive than other cold sore treatments on the market.

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If you're looking for a natural and effective cold sore treatment, Burt's Bees Cold Sore Treatment Rapid Rescue is a great option.

Pros

  • The combination of botanicals and moisturizers provide relief and protection for cold sore and fever blister symptoms.
  • Soothing rhubarb and sage complex, along with menthol and peppermint oil, provide temporary relief.
  • The 100% natural origin formula is free from parabens, phthalates, petrolatum, and SLS.

Cons

  • The cooling menthol may be too intense for some users.
  • The product may not work as quickly as some other cold sore treatments.
  • The price may be higher than some other options on the market.

We recently tried out Burt's Bees Cold Sore Treatment Rapid Rescue and were impressed with the results. The formula is gentle and natural, yet effective at providing relief for cold sore symptoms. The rhubarb and sage complex, along with the cooling menthol, helped to soothe and calm the affected area.

While the product may not work as quickly as some other cold sore treatments, we appreciated the fact that it is made with natural ingredients and is free from harmful chemicals. The price may be a bit higher than other options on the market, but we believe the quality and effectiveness of the product is worth it.

Overall, we would highly recommend Burt's Bees Cold Sore Treatment Rapid Rescue to anyone looking for a natural and effective solution to cold sore symptoms.

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We highly recommend purchasing Orajel Moisturelock Cold Sore Symptom Treatment if you're looking for a fast-acting solution to treat cold sores.

Pros

  • Instant pain relief
  • Skin protectant
  • Moisturelock cream

Cons

  • Small amount of product
  • May need to reapply throughout the day
  • Not eligible for international shipping

This product is a lifesaver for anyone suffering from cold sores. The moisturelock cream provides instant pain relief and helps to protect chapped lips while treating the pain, itching, and dryness associated with cold sores. The maximum strength benzocaine provides an added layer of relief, making it an effective treatment option.

One downside of this product is the small amount of product in each tube, which may require reapplication throughout the day. Additionally, it is not eligible for international shipping, which may be a drawback for some customers.

Overall, we highly recommend Orajel Moisturelock Cold Sore Symptom Treatment for anyone looking for an effective and fast-acting solution to treat cold sores.

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If you're looking for a fast and effective solution to your cold sores, Abreva 10 Percent Docosanol Cold Sore Treatment is a great option.

Pros

  • Abreva is the number one cold sore brand on the market.
  • This lip cream is clinically proven to shorten the duration of cold sore symptoms.
  • The pump bottle is easy to apply and take on the go.

Cons

  • The product can be a bit pricey compared to other cold sore treatments.
  • It needs to be applied five times a day until the cold sore is fully healed.
  • It may not work for everyone.

We've personally used Abreva and found that it works quickly to relieve cold sore symptoms. The cream is smooth and easy to apply, and the pump bottle makes it convenient to take with you wherever you go.

Abreva contains 10 percent docosanol, which is scientifically-proven to shorten cold sore healing time. It creates a barrier around healthy skin cells to prevent the spread of the herpes simplex virus type 1 (HSV-1). When used at the first sign of a tingle, Abreva can shorten the duration of tingling, pain, burning, and itching associated with cold sores.

While Abreva is a bit more expensive than other cold sore treatments on the market, we think it's worth the investment. It's a nonprescription medicine that has been dermatologist recommended and clinically proven to work. Plus, the pump bottle makes it easy to apply and take with you on the go.

Overall, if you're looking for a fast and effective cold sore treatment, we highly recommend giving Abreva 10 Percent Docosanol Cold Sore Treatment a try.

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If you're looking for a fast-acting and soothing treatment for cold sores, MERIX Cold Sore Treatment is a great option.

Pros

  • Treats cold sores/fever blisters
  • Soothing and non-irritating
  • Patented Viracea formula

Cons

  • May not work for everyone
  • Some users report a stinging sensation upon application
  • Only available in one size

We've tried many different cold sore treatments over the years, and MERIX is definitely one of the best. The patented Viracea formula is effective at treating cold sores and fever blisters, while also soothing and non-irritating to the skin.

One thing to keep in mind is that MERIX may not work for everyone. Some users report that it didn't have any effect on their cold sores, while others found it to be a lifesaver. Additionally, some users report a stinging sensation upon application, although this usually subsides quickly.

Overall, we would definitely recommend giving MERIX a try if you're looking for a fast-acting and soothing cold sore treatment. Just be aware that it may not work for everyone and may cause a stinging sensation upon application.

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If you're looking for a fast-acting cold sore treatment that provides rapid pain relief, then Abreva Cold Sore Treatment Rapid Pain Relief Cream might be the right product for you.

Pros

  • One tube of Abreva Cold Sore Rapid Pain Relief, 3 grams
  • Shortens duration of tingling, pain, burning and itching
  • Easy applicable tube form for on-the-go use

Cons

  • The cap is a bit tricky to open and close
  • Has a weird menthol (Ben Gay type) smell
  • Expensive compared to other lidocaine pain options available on the market

Abreva Cold Sore Treatment Rapid Pain Relief Cream is a great option for those who want to tackle cold sores quickly. With its easy-to-apply tube form, it's perfect for on-the-go use, and it helps to shorten the duration of tingling, pain, burning, and itching associated with cold sores if used as directed at the first sign of a tingle.

While the product provides rapid pain relief, it does have a few cons. The cap is a bit tricky to open and close, which can be frustrating, and it has a weird menthol (Ben Gay type) smell that some users might not like. Additionally, it's more expensive than other lidocaine pain options available on the market.

Overall, Abreva Cold Sore Treatment Rapid Pain Relief Cream is a great option for those who want to tackle cold sores quickly and effectively. However, if you're looking for a more affordable option or don't like the smell, then it might not be the best choice for you.

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We highly recommend the Viconor Red Light Cold Sore Treatment for anyone looking for an effective and versatile solution to cold sores and mouth ulcers.

Pros

  • The device offers three different types of infrared light therapy, allowing for customized treatment depending on the severity of the symptoms.
  • The 2-in-1 design is incredibly convenient, allowing the device to be used for both face and body pain relief.
  • The device is compact and portable, making it easy to take on the go.

Cons

  • The device may not be as effective for more severe cold sores or ulcers.
  • Some users may find the device to be a bit pricey.
  • The device requires a bit of a learning curve to use effectively.

We found the Viconor Red Light Cold Sore Treatment to be incredibly effective in treating mild to moderate cold sores and mouth ulcers. The three different types of infrared light therapy allow for customized treatment depending on the severity of the symptoms, and the 2-in-1 design is incredibly convenient for both face and body pain relief. The device is also compact and portable, making it easy to take on the go.

However, the device may not be as effective for more severe cold sores or ulcers, and some users may find the device to be a bit pricey. Additionally, the device requires a bit of a learning curve to use effectively, but with a bit of practice, it becomes much easier to use.

Overall, we highly recommend the Viconor Red Light Cold Sore Treatment for anyone looking for an effective and versatile solution to cold sores and mouth ulcers.

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We highly recommend Herpecin L Lip Balm Stick for those who suffer from cold sores and chapped lips.

Pros

  • Herpecin L Everyday Protection helps relieve and protect against cold sores, fever blisters, and chapped lips.
  • Herpecin L is formulated with lysine, Vitamins C, B6, and E, lemon balm and added SPF 30 protection.
  • Herpecin L soothes, moisturizes & creates an SPF 30 barrier to protect your lips against the sun's harmful UV rays.

Cons

  • Herpecin L may not work for everyone.
  • Some users may find the formula to be too thick.
  • The small size of the tube may not last long for frequent users.

Herpecin L is a great lip balm for those who suffer from cold sores and chapped lips. It's formulated with lysine, Vitamins C, B6, and E, lemon balm and added SPF 30 protection, providing real relief from herpes related cold sores from real medicine. It also protects your lips from the sun's harmful UV rays.

The formula is thick and moisturizing, which can help soothe and heal chapped lips. It's easy to apply and absorbs quickly, leaving your lips feeling soft and smooth. Some users may find that the formula is too thick, but it's perfect for those who suffer from dry or cracked lips.

The small size of the tube may not last long for frequent users, but it's easy to carry in your pocket or purse. Herpecin L may not work for everyone, but it's definitely worth a try if you suffer from cold sores or chapped lips.

Overall, Herpecin L Lip Balm Stick is a great product for those who suffer from cold sores and chapped lips. It provides real relief from herpes related cold sores from real medicine, and protects your lips with SPF 30.

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We highly recommend Campho-Phenique Cold Sore Treatment for anyone looking for an effective and fast-acting solution for cold sores and fever blisters.

Pros

  • Instantly relieves pain and itch
  • Helps prevent infection to promote healing
  • Can be used by adults and children over 2 years old

Cons

  • May cause a slight burning sensation upon application
  • May not be effective for severe cases
  • Small amount of product in tube

After using Campho-Phenique Cold Sore Treatment, we were impressed with its ability to quickly relieve pain and itch. The gel formula is easy to apply and helps prevent infection, promoting faster healing. It's also safe for children over 2 years old, making it a great option for families.

However, we did experience a slight burning sensation upon application, which may not be suitable for those with sensitive skin. Additionally, the small amount of product in the tube may not be enough for severe cases of cold sores.

Overall, Campho-Phenique Cold Sore Treatment is a great option for anyone looking for a fast-acting and effective solution for cold sores and fever blisters.

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We highly recommend purchasing Herpecin-L Lip Protectant/cold Sore & Sunscreen Lip Balm Twin Pack for anyone looking for a reliable cold sore treatment with added sun protection.

Pros

  • Provides real relief from cold sores and fever blisters
  • Contains SPF 30 to protect lips from sun damage
  • Soothes and moisturizes dry, chapped lips

Cons

  • May cause a burning sensation upon application
  • Comes out of the tube easily, which can be messy
  • Adverse reactions may occur in some individuals

Herpecin-L is a lip balm formulated to treat cold sores and protect lips from the sun's harmful UV rays. Its unique formula contains lysine, Vitamins C, B6, and E, lemon balm, and added SPF 30 protection. This lip balm provides real relief from herpes related cold sores and helps to heal painful cracking of lips without numbing or drying.

One of the standout features of Herpecin-L is its SPF 30 protection. UV rays can increase your risk of sun cancer, chapped lips, early skin aging, and damaged skin, which can promote the development of cold sores. Herpecin-L lip balm can help prevent sunburn and protect your lips from further damage.

While Herpecin-L provides real relief from cold sores and fever blisters, it may cause a burning sensation upon application. Additionally, the lip balm comes out of the tube easily, which can be messy. Some individuals may also experience adverse reactions to the product.

In conclusion, if you're looking for a reliable cold sore treatment with added sun protection, Herpecin-L Lip Protectant/cold Sore & Sunscreen Lip Balm Twin Pack is a great option. Its unique formula provides real relief from cold sores and fever blisters, while also protecting your lips from the sun's harmful UV rays.

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We highly recommend the LOONLAI Red Light Therapy Device for anyone who needs to relieve muscle stiffness, reduce inflammation, and promote faster healing. The device is user-friendly, portable, and comes with a detachable tip for facial and body therapy.

Pros

  • The device has enhanced wavelengths of red and infrared light that are beneficial for the body.
  • It is a 2-in-1 facial and body therapy device that targets mouth, nose, and ear with the tip on, and it can be used for pain relief and healing for neck, shoulder, wrist, finger, waist, knee, ankle, joints, etc.
  • The device has an exclusive pulse mode that reduces tissue heating to avoid overheating and is safe and easy to use.

Cons

  • The device may feel too hot for some users, but the pulsed mode is a considerate choice.
  • The description stating that it's good for the whole body may be a little overestimated.
  • The light is pretty bright, and some users may need to wear protective eyewear.

We found the LOONLAI Red Light Therapy Device to be effective in reducing inflammation, easing pain, and promoting faster healing. The device is lightweight, portable, and user-friendly, making it ideal for traveling. The detachable tip is a great feature that allows for facial and body therapy, and the exclusive pulse mode is a considerate choice for thin skin. Overall, we think this is a great product for anyone who needs red light therapy.

Buying Guide

When choosing a cold sore treatment, there are a few key features to consider. We recommend taking the following factors into account before making a purchase:

1. Effectiveness

The most important factor to consider when choosing a cold sore treatment is its effectiveness. Look for products that are clinically proven to reduce the duration and severity of cold sores. Check the product's active ingredients and make sure they are backed by scientific research.

2. Application

Consider how the treatment is applied. Some products come in the form of creams, gels, or ointments that are applied directly to the affected area. Others come in the form of patches or oral medications. Choose a product that is easy to apply and fits your lifestyle.

3. Safety

Make sure the cold sore treatment you choose is safe for use. Check the product's ingredients and make sure they are not known to cause any adverse reactions. If you have any allergies or sensitivities, be sure to check the label carefully before making a purchase.

4. Price

Cold sore treatments can vary widely in price. Consider your budget and look for products that offer good value for money. Keep in mind that the most expensive product is not always the most effective.

5. Convenience

Consider the convenience of the product. Look for products that are easy to carry with you and can be applied on the go. Some products come in small, portable packaging, while others require a more elaborate application process.

We hope this guide has helped you choose the best cold sore treatment for your needs. Remember to always follow the instructions carefully and consult a healthcare professional if you have any concerns.

Frequently Asked Questions

1. What is the best prescription for cold sores?

There are several prescription medications available to treat cold sores. Acyclovir, valacyclovir, and famciclovir are the most commonly prescribed antiviral medications for cold sores. These medications can help reduce the severity and duration of cold sore outbreaks when taken as directed by a healthcare provider.

2. How to prevent cold sores?

Preventing cold sores can be challenging, but there are a few things you can do to reduce your risk of getting them. Avoid close contact with people who have active cold sores, and don't share items like utensils, towels, or lip balm with others. Practice good hand hygiene, and avoid touching your face or mouth as much as possible. If you are prone to cold sores, talk to your healthcare provider about antiviral medications you can take to prevent outbreaks.

3. What causes cold sores?

Cold sores are caused by the herpes simplex virus (HSV). There are two types of HSV: HSV-1 and HSV-2. Cold sores are usually caused by HSV-1, which is highly contagious and can be spread through close contact with someone who has an active cold sore.

4. Does lysine work better than abreva?

Lysine is an amino acid that is sometimes used to treat cold sores. While some people believe that lysine can help reduce the severity and frequency of cold sore outbreaks, there is little scientific evidence to support this claim. Abreva, on the other hand, is an FDA-approved over-the-counter medication that has been clinically proven to shorten the healing time of cold sores.

5. Is it better to keep a cold sore moist or dry?

It is generally recommended to keep a cold sore moist to help prevent cracking and bleeding. Applying a cold sore cream or ointment can help keep the area moist and provide some relief from pain and itching. However, it is important to avoid touching the cold sore as much as possible, as this can spread the virus to other parts of your body or to other people.

6. Does abreva actually work?

Yes, abreva has been clinically proven to shorten the healing time of cold sores. When applied as directed at the first sign of a cold sore, abreva can help reduce the severity and duration of the outbreak. However, it is important to remember that abreva is most effective when used as directed, and it may not work for everyone.

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