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GenF20 Plus Reviews: Is it Worth Your Money?

Written by Andrew Le, MD

UpdatedFebruary 29, 2024

As we age, our body’s natural production of human growth hormone (GH) decreases, leading some to explore supplementation with GH as a means of reversing the effects of aging. However, the use of real or synthetic GH can lead to negative side effects such as joint and muscle pain, edema, and even diabetes.

Enter GenF20 Plus, a dietary supplement that aims to stimulate the pituitary gland to produce more GH. In this article, we will examine the science behind GenF20 Plus to determine if its ingredients offer a safe alternative to direct GH supplementation and if it can truly deliver on its promises of anti-aging effects and increased vitality.

GenF20 Plus

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What is GenF20 Plus?

GenF20 Plus is a nutritional supplement that aims to increase GH production and help fight the aging process. It contains a moderately dosed amino acid profile, including two out of three branched-chain amino acids. The product’s parent company, Leading Edge Health, produces several GH boosters advertised for specific goals like fighting aging or building muscle.

The supplement is intended as a daily supplement and can be obtained as a one-, three-, or six-month supply. Leading Edge Health offers bulk-purchasing discounts that can reduce your monthly cost if you have the capital to spend more up-front. Other GH boosters on the market are priced similarly and contain ingredients and doses comparable to GenF20 Plus.

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How GenF20 Plus Works

GenF20 Plus is a dietary supplement designed to stimulate the production of human growth hormone (HGH) in the body. HGH is a hormone produced by the pituitary gland that plays a key role in growth, cell regeneration, and maintaining healthy tissue throughout the body. As we age, our body's natural production of HGH declines, which can lead to a variety of negative health effects.

GenF20 Plus works by using a combination of amino acids, herbs, and other natural ingredients that have been shown to boost HGH production. While the supplement does not contain real or synthetic HGH, it is designed to stimulate the body's own production of the hormone.

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What Ingredients are in GenF20 Plus?

GenF20 Plus contains a variety of ingredients that have been shown to have potential for increasing HGH production. Here is a breakdown of some of the key ingredients:

GTF Chromium

GTF chromium is a mineral that has been shown to help improve insulin sensitivity and glucose control in individuals with Type 2 diabetes. While some studies have indicated an increase in IGF-1 expression in the presence of insulin, more research is needed to understand its glucose-regulating mechanism of action.


L-arginine is an amino acid that has been shown to dramatically increase GH levels, especially when combined with physical activity. Some studies have also indicated its potential when combined with other amino acids.


L-glutamine is an amino acid that has been shown to increase circulating GH in a small-scale study. However, more research is needed to understand its effect on growth hormone.


L-glycine has been shown to stimulate GH production in the pituitary gland, but successful studies in humans have involved doses much higher than what is found in GenF20 Plus.


L-tyrosine appears to play a significant role in the suppression of somatostatin, a peptide responsible for inhibiting GH release. However, more research is needed to understand its impact on growth hormone.


One promising study looking into L-lysine's potential to boost GH included a combination of lysine and arginine. However, the study used much higher doses than what is found in GenF20 Plus, and more recent reviews have found those three amino acids to be largely ineffective as GH boosters.

Tribulus Terrestris

Tribulus terrestris is often found in testosterone boosters, where it has some clinical support for its potential to increase T levels in deficient men. While some studies indicate its potential to increase IGF-1, others only find that it can mitigate muscle damage without evidence of a growth hormone effect.

Astragalus Root Extract

Studies have linked astragalus root extract to increased IGF-1 levels, which are typically linked with circulating growth hormone. More research is needed to understand its impact on GH.


Colostrum contains IGF-1, a hormone produced by the body when GH is released. However, studies show that consuming it does not increase IGF-1 in the blood, and its effect on GH appears nonexistent.

Deer Antler Velvet

Studies have obliquely linked deer antler velvet to cardiovascular health and the management of uterine fibroids. However, a study looking directly at the effects of a similar velvet harvested from elk found no meaningful difference between it and a placebo for hormone levels or exercise performance.

Gamma-Aminobutyric Acid

Gamma-aminobutyric acid (GABA) offers several health benefits, and one small study found significant increases in GH at rest and after exercise. However, the study used much higher doses than what is found in GenF20 Plus.

L-Isoleucine and L-Valine

L-isoleucine and L-valine are two of three branched-chain amino acids (BCAA) that are consistently utilized before and after workouts to increase exercise performance and improve recovery. More research needs to be conducted to determine their potential to influence growth hormones.

Overall, GenF20 Plus contains a variety of ingredients that have shown potential for increasing GH production. However, more research is needed to fully understand their impact on the hormone and the body.

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How much does GenF20 Plus cost?

If you're considering trying GenF20 Plus, you may be wondering how much it will cost you. GenF20 Plus used to be available in monthly supplies of 1-6 months, but Leading Edge Health has since reduced the available quantities to one, three, and six months. Free shipping was also previously available with orders of three months or more, but it's now available on all purchases.

When you purchase a monthly supply of GenF20 Plus, you'll be prompted to add a supply of GenF20 Plus Alpha GPC Oral Spray for an extra $50. The supplement and spray constitute the GenF20 Plus Anti-Aging System, and you would take them together daily. The spray contains mostly the same ingredients as the tablet, but it also includes Alpha GPC, Mucuna pruriens, and moomiyo. Alpha GPC has been shown to increase the secretion of growth hormones in 1,000mg doses, and the L-dopa in Mucuna pruriens appears capable of influencing growth hormone levels in 500mg doses. Unfortunately, Leading Edge Health is not forthcoming with the doses in its GenF20 oral spray, so we cannot recommend it at this time.

As we've discussed above, these prices are on the high side among GH supplements, and they're significantly higher than many amino acid supplements that can give you more clinically relevant doses of amino acids with clinical links to growth hormone production. You'll miss out on some ancillary botanical ingredients, and you might not get much of a money-back guarantee, but the odds of the supplement working in the first place are likely higher.

GenF20 Plus money-back guarantee

Like most Leading Edge Health products, GenF20 Plus comes with a 67-day money-back guarantee. Compared to other GH-boosting supplements, this is about average among companies that offer them, with the range typically running from 60-90 days. The idea with the extra seven days is that you can try the product for two months and not feel rushed when setting up a return. It's a considerate policy, and unlike many other supplements that can take 8-12 weeks to start showing results, GH studies often look at serum IGF-1 levels within 90 minutes of consumption. That means you should be able to know whether the supplement is working for you by the two-month point.

If you can afford the larger dollar amount initially, buying larger quantities makes sense because of the 67-day money-back guarantee. If you buy a larger amount, you'll end up with more per dollar as long as you're happy with the results after two months.

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Your alternatives and how GenF20 Plus compares

If you're looking for a GH booster for a specific purpose, it might be worthwhile to consider how GenF20 Plus stacks up to the competition. Other GH boosters with similar ingredients are marketed as muscle-building tools or cardio enhancers. However, if you're looking for alternative anti-aging supplements, several products contain ingredients that can help fight aging.

Other GH boosters

Supplements intended to boost growth hormone in humans typically contain similar ingredients. Several of the most well-known are all created by Leading Edge Health, GenF20 Plus’ parent company. One under that umbrella even has an identical ingredient list to GenF20 Plus. Here's a breakdown of some of GenF20 Plus’ most direct competition in the GH space:


Provacyl is a GenF20 Plus alternative sold by Leading Edge Health that costs about $10 less per month than GenF20 Plus. It may be superior for general health, as it contains a few vitamins and minerals, and the rest of its formula nearly mirrors GenF20 Plus. But its doses, especially those of its amino acids, are far lower.

HyperGH 14X

This is another product sold by Leading Edge Health, and it’s completely identical to GenF20 Plus in its active ingredients — the same components at the same doses for the same price. Leading Edge Health markets it to men looking for an edge in building muscle.


HGH-X2 is marketed as a legal alternative to steroids by a company called CrazyBulk. HGH-X2 is about $5 less per month than GenF20 Plus, but it only contains four ingredients, at least two of which appear in paltry doses that may have little-to-no effect.

Amino acid supplements

Different amino acid mixtures have endured multiple clinical trials to see how they might affect exercise performance, muscle building and recovery, and serum levels of GH and IGF-1. Some combinations and doses have proven more effective than others, but GenF20 Plus puts enough of them together that it might prove to be the most effective aspect of its formula. Still, its doses are far lower than those seen in dedicated amino acid supplements and drinks designed as pre- and post-workout aids.

Naked EAAs

Naked Nutrition produces some of the cleanest supplements on the market, and its Essential Amino Acids (EAAs) contains nearly ten times the isoleucine and valine found in GenF20 Plus, in addition to the third branched-chain amino acid, leucine. It’s also less expensive than GenF20 Plus, at just $40 for 50 servings. All told, it offers nine amino acids totaling 9.3g, but it doesn’t include L-arginine.

Bulk Nutrition EAA powder

We’d recommend this product to anyone looking for a generous dose of essential amino acids at a low price. It boasts a 10g formula of all nine essential amino acids, but the exact doses of each are obscured by a proprietary blend. That said, you can get about the same quantity you would from Naked for under $23.

Rule1 Essential Amino 9

Rule 1’s Essential Amino 9 has a slightly lower dose than Naked or Bulk Supplements, but it contains an electrolyte complex that might make it a better choice as a pre- or post-workout drink.

GABA supplements

Another alternative supplement to a GH booster is a product made primarily with GABA (gamma-aminobutyric acid). This neurotransmitter is naturally found in foods like spinach, broccoli, and kale, and it is generally taken to help improve sleep, mood, anxiety, PMS, ADHD, blood pressure, fat burning, exercise recovery, and muscle building.

Taking GABA may help the body produce more GH, although studies are still inconclusive. GABA supplements are popular and a generally safe alternative to GH supplements. GenF20 Plus contains GABA as one of its components. So if you’re concerned about any of GenF20 Plus’s other components, you can opt for a supplement with GABA as a primary ingredient.

GABA supplements are often much more cost-effective than a supplement designed as a GH booster. For example, NOW’s GABA supplement costs only $13.99 for 100 capsules, which could be a 50- or 33-day supply depending on your preferred dose. Each capsule contains 500mg of GABA, compared to 50mg per tablet of GenF20 Plus.

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Frequently Asked Questions

What are the ingredients in GenF20 Plus?

GenF20 Plus is a natural supplement that contains a blend of amino acids, vitamins, and minerals. The key ingredients include L-Arginine, L-Glutamine, L-Glycine, L-Lysine, L-Tyrosine, Astragalus Root Extract, Deer Antler Velvet, GABA, Colostrum, and Phosphatidylcholine.

How does GenF20 Plus work?

GenF20 Plus works by boosting the production of human growth hormone (HGH) in the body. HGH is responsible for cell growth, regeneration, and maintaining healthy tissue throughout the body. As we age, our HGH levels naturally decline, leading to a variety of age-related symptoms. GenF20 Plus helps to reverse these symptoms by increasing HGH production, leading to improved energy, metabolism, and overall well-being.

What are the benefits of using GenF20 Plus?

The benefits of using GenF20 Plus include improved physical appearance, increased energy and metabolism, enhanced immune function, and improved overall well-being. It also helps to reduce the signs of aging, such as wrinkles, fine lines, and age spots.

Are there any side effects of using GenF20 Plus?

GenF20 Plus is a natural supplement and is generally considered safe for most people. However, some users may experience mild side effects, such as headaches, nausea, or upset stomach. If you experience any severe side effects, stop using the supplement immediately and consult with your healthcare provider.

How long does it take to see results with GenF20 Plus?

The results of using GenF20 Plus may vary depending on the individual. However, most users report seeing results within 2-3 months of consistent use. It is important to note that results may take longer for some users, and it is recommended to use the supplement for at least 6 months to see maximum benefits.

Where can I buy GenF20 Plus?

GenF20 Plus can be purchased from the official website or from authorized retailers. It is important to only purchase from reputable sources to ensure the authenticity of the product.

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