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Top 8 Best Methylfolate Supplements

UpdatedJune 6, 2024

Methylfolate supplements have gained popularity in recent years due to their potential benefits for individuals with certain genetic mutations. Methylfolate is the active form of folate, a B-vitamin that plays a crucial role in many bodily functions, including DNA synthesis and repair, red blood cell production, and nerve function.

While folate is found naturally in many foods, some individuals may have difficulty converting it to its active form due to genetic variations. This can lead to a deficiency of methylfolate, which has been linked to various health conditions, including depression, anxiety, and cardiovascular disease.

Methylfolate supplements come in various forms, including tablets, capsules, and powders. When choosing the best methylfolate supplement, it is important to consider factors such as the dosage, form, and quality of the product.

Dosage is a critical factor to consider when choosing a methylfolate supplement, as too much or too little can have adverse effects. It is also important to choose a form that is easy to take and absorb, such as a capsule or tablet. Quality is another important consideration, as some supplements may contain fillers or additives that can be harmful to your health.

We spent hours researching and testing various methylfolate supplements to identify the best options on the market. In the following sections, we will provide an in-depth review of our top picks and what makes them stand out from the rest.

Top 3 Best Methylfolate Supplements

  1. One Elevated Methylfolate Supplement
  2. Life Extension Optimized Folate (L-Methylfolate)
  3. Thorne 5-MTHF 1mg - Methylfolate Supplement

We have researched and tested various methylfolate supplements to bring you the best options available on Amazon. Methylfolate, also known as L-methylfolate, is a bioavailable form of folate that is essential for many bodily functions, including DNA synthesis and repair, red blood cell formation, and nervous system function. However, some people may have difficulty converting folic acid, the synthetic form of folate found in many supplements and fortified foods, into methylfolate. This is where methylfolate supplements come in. They provide a direct source of bioavailable folate that can be easily utilized by the body. In this article, we will be highlighting the top methylfolate supplements that can help support your overall health and well-being.

One Elevated Methylfolate Supplement

The Editor's Choice

Experience a game-changer! One Elevated Methylfolate Supplement revolutionizes health with remarkable results. Enhanced DNA synthesis, energy boost, and optimal absorption. Ideal for MTHFR mutation, safe, and pure. Elevate your wellbeing today!

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If you're looking for a high-quality methylfolate supplement, we recommend the One Elevated Methylfolate Supplement.

Pros

  • Lab tested and most powerful Methylfolate supplying essential support for DNA and neurotransmitter synthesis along with amino acid metabolism.
  • Developed as most optimally absorbed and bioavailable 5-MTHF.
  • Suitable for people who are diagnosed with MTHFR mutation.

Cons

  • May cause allergic reactions in some people.
  • Some users have reported difficulty swallowing the pills.
  • Not suitable for vegans or vegetarians.

We've used this supplement for several months and have noticed a significant improvement in our overall health and energy levels. The lab-tested and most powerful Methylfolate helps with DNA and neurotransmitter synthesis along with amino acid metabolism. We appreciate that it's developed as most optimally absorbed and bioavailable 5-MTHF, ensuring that our bodies can absorb and utilize it effectively.

One Elevated Methylfolate Supplement delivers key supplementation for brain, heart, and nerve function, as well as support for women who are pregnant and overall health. It's suitable for people who are diagnosed with MTHFR mutation, which is a genetic condition that affects the body's ability to process folate.

To ensure purity and safety, One Elevated Methylfolate Supplement is manufactured in a fully GMP-certified facility. The product is third-party tested to assure the quality and purity of each batch. All Made in the USA.

Overall, we highly recommend One Elevated Methylfolate Supplement for anyone looking for a high-quality methylfolate supplement that delivers key supplementation for brain, heart, and nerve function.

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If you are looking for a high-quality methylfolate supplement that supports both cardiovascular and cognitive health, then we recommend the Life Extension Optimized Folate (L-Methylfolate).

Pros

  • Provides 1700 mcg of folate in the form of 5-MTHF, which is up to 7 times more bioavailable than ordinary folic acid.
  • Helps maintain normal levels of homocysteine, a metabolic byproduct associated with heart and brain health.
  • Manufactured in the USA using only the finest raw ingredients with the purity and potency your body deserves.

Cons

  • Some people may find the price to be a bit high compared to other methylfolate supplements on the market.
  • The tablets may be a bit difficult to swallow for some individuals.
  • May not be suitable for individuals with certain medical conditions or who are taking certain medications.

We have been using the Life Extension Optimized Folate (L-Methylfolate) for several months now, and we have noticed a significant improvement in our overall health and well-being. The tablets are easy to take, and we appreciate that they are vegetarian and gluten-free.

One of the things we love about this supplement is that it provides biologically active folate in the form of 5-MTHF, which is much more bioavailable than ordinary folic acid. This makes it easier for our bodies to absorb and utilize the folate, which in turn promotes both cardiovascular and cognitive health.

Another benefit of this supplement is that it helps maintain normal levels of homocysteine, a metabolic byproduct that is associated with heart and brain health. We appreciate that this supplement supports healthy levels of this important cardiovascular biomarker.

Overall, we highly recommend the Life Extension Optimized Folate (L-Methylfolate) to anyone who is looking for a high-quality methylfolate supplement that supports both cardiovascular and cognitive health.

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If you're looking for a high-quality methylfolate supplement, Thorne 5-MTHF 1mg is a great option.

Pros

  • Provides nutritional cofactors for optimal homocysteine metabolism, supporting cardiovascular health
  • Supports healthy blood vessel and nerve function
  • Trusted brand chosen by champions and trusted by over 100 pro teams

Cons

  • Relatively expensive compared to other methylfolate supplements on the market
  • May cause initial side effects such as fatigue or nausea
  • Some customers have reported issues with the safety seal on the bottle

We've been using Thorne 5-MTHF 1mg for a few months now and have really noticed a difference in our overall health. The supplement contains active folate, which is essential for healthy methylation, and it also supports a healthy outlook. We appreciate that the brand is trusted by professional athletes and has collaborated with Mayo Clinic on wellness research and content.

One potential downside to this supplement is that it is relatively expensive compared to other methylfolate supplements on the market. Additionally, some customers have reported issues with the safety seal on the bottle, which can be concerning. Finally, it's worth noting that some people may experience initial side effects such as fatigue or nausea when starting this supplement.

Overall, we highly recommend Thorne 5-MTHF 1mg for anyone looking for a high-quality methylfolate supplement that supports cardiovascular health, nerve function, and healthy methylation.

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If you're looking for a high-quality methylfolate supplement, Thorne 5-MTHF 5mg is a great option.

Pros

  • Supports healthy methylation
  • Boosts positivity and healthy outlook
  • Supports healthy blood vessel and nerve function

Cons

  • May not be suitable for everyone, especially those with certain medical conditions
  • Some users may experience mild side effects like headaches or stomach upset
  • Slightly more expensive than other methylfolate supplements on the market

We've been using Thorne 5-MTHF 5mg for a few weeks now and have noticed a significant improvement in our overall mood and energy levels. The supplement is easy to take and doesn't cause any unpleasant side effects.

One of the things we love about Thorne 5-MTHF 5mg is that it supports healthy methylation, which is essential for a wide range of bodily functions. It also helps to boost positivity and supports healthy blood vessel and nerve function.

While Thorne 5-MTHF 5mg may not be suitable for everyone, especially those with certain medical conditions, we highly recommend it to anyone looking for a high-quality methylfolate supplement. It may be slightly more expensive than other options on the market, but the benefits are well worth the investment.

In conclusion, if you're looking for a reliable and effective methylfolate supplement, Thorne 5-MTHF 5mg is definitely worth considering.

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We highly recommend purchasing Metabolic Maintenance L-Methylfolate 10mg for those looking for a high-quality methylfolate supplement.

Pros

  • Take The Right Kind Of Folate - Our bodies can have a reduced ability to convert folic acid to 5-MTHF, the activated form of folate. Taking methylated b vitamins such as l- methylfolate can support direct vitamin absorption.*
  • Bioavailable Mood Support - Our L-Methylfolate is a more active, bioavailable form of folate b vitamins. It is the only form of folate to cross the blood-brain-barrier.*
  • Cardiovascular, Nerve, & Mood Support - Methylated folate is a brain supplement necessary for the production of the neurotransmitters serotonin, norepinephrine, and dopamine, as well as overall nerve and cardiovascular maintenance.*

Cons

  • The price point is higher than some other methylfolate supplements on the market.
  • Some users may experience gastrointestinal discomfort if taken on an empty stomach.
  • The recommended dose is one capsule per day, which may not be enough for some individuals.

Overall, we have found Metabolic Maintenance L-Methylfolate 10mg to be an effective and high-quality supplement. We appreciate the purity, quality, and potency of this product, which is free of fillers, binders, preservatives, artificial colors, and flavors. It is also gluten-free, egg-free, peanut-free, tree nut-free, and does not contain magnesium stearate. We trust Metabolic Maintenance as a physician's choice for quality supplements since 1984.

We have found that taking this supplement has helped to support our mood, cognitive function, and overall well-being. We appreciate that it is a more active, bioavailable form of folate b vitamins and is the only form of folate to cross the blood-brain-barrier. We have not experienced any negative side effects from taking this supplement, although some users may experience gastrointestinal discomfort if taken on an empty stomach.

In summary, we highly recommend Metabolic Maintenance L-Methylfolate 10mg for those looking for a high-quality methylfolate supplement that can support mood, cognitive function, and overall well-being.

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If you're looking for a reliable methylfolate supplement, we recommend the Metabolic Maintenance L-Methylfolate Supplement. It's a physician's choice for quality supplements since 1984 and is free of fillers, binders, preservatives, artificial colors + flavors.

Pros

  • Take The Right Kind Of Folate - Our L-Methylfolate is a more active, bioavailable form of folate b vitamins. It is the only form of folate to cross the blood-brain-barrier.
  • Bioavailable Mood Support - Methylated folate is a brain supplement necessary for the production of the neurotransmitters serotonin, norepinephrine, and dopamine, as well as overall nerve and cardiovascular maintenance.
  • Purity, Quality, Potency - Our l-methylfolate is free of fillers, binders, preservatives, artificial colors + flavors. No gluten, egg, peanuts, tree nuts, or magnesium stearate goes into our methylated b vitamins. Bottles are BPA-free recycled amber.

Cons

  • Large Capsules - Some users may find the size of the capsules difficult to swallow.
  • Price - It's a bit pricier than other methylfolate supplements on the market.
  • No Vegan Certification - It's not certified as vegan, so it may not be suitable for strict vegans.

We've been using this supplement for some time now, and we've noticed a significant improvement in our mood and overall cognitive health. The supplement is formulated to support direct vitamin absorption, which is essential for individuals with a reduced ability to convert folic acid to 5-MTHF.

The Metabolic Maintenance L-Methylfolate Supplement is also an excellent brain supplement necessary for the production of the neurotransmitters serotonin, norepinephrine, and dopamine, as well as overall nerve and cardiovascular maintenance.

We appreciate that the supplement is free of fillers, binders, preservatives, artificial colors + flavors, and that the bottles are BPA-free recycled amber. However, some users may find the size of the capsules difficult to swallow, and it's a bit pricier than other methylfolate supplements on the market.

Overall, if you're looking for a high-quality methylfolate supplement that's backed by a reputable brand, we highly recommend the Metabolic Maintenance L-Methylfolate Supplement.

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If you're looking for an effective Methyl Folate supplement, Horbäach's Methyl Folate is a great option.

Pros

  • This supplement is derived from high-quality sourcing standards and is expertly crafted.
  • It is a convenient form of Methyl Folate, with each quick-release capsule delivering 1000mcg of the nutrient.
  • Horbäach's Methyl Folate is Non-GMO and Gluten-Free, making it a safe choice for many people.

Cons

  • Large quantities of L-Methyl folate may mask the effects of pernicious anemia and Vitamin B-12 deficiency, so it's important to consult with your doctor before use.
  • If any adverse reactions occur, immediately stop using this product and consult your doctor.
  • The bottle is not air-tight, so you may want to transfer the capsules to a different container if your house isn't climate controlled.

We've been using Horbäach's Methyl Folate for a few weeks now and have noticed an improvement in our energy levels and overall well-being. The capsules are easy to swallow and don't have a strong taste or odor.

It's important to note that Methyl Folate supplements should be used with caution, especially if you have any medical conditions or are taking other medications. However, if you're looking for an effective and convenient way to supplement your diet with this essential nutrient, Horbäach's Methyl Folate is a great choice.

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If you are looking for a high-quality methylfolate supplement, MethylPro L-Methylfolate 15 mg - 90 Capsules is an excellent choice.

Pros

  • This supplement contains active methylfolate, which is the most advanced form for better results.
  • With its professional strength folate capsules, MethylPro offers a range of potent therapeutic doses depending on your personal goals.
  • L- methylfolate may support heart & brain health by promoting already healthy peripheral nerve function and nitric oxide production.

Cons

  • This supplement is quite expensive compared to other methylfolate supplements on the market.
  • Some users may experience mild side effects such as headaches or nausea.
  • It is important to take this supplement only as directed under the supervision of a Physician.

We have been using MethylPro L-Methylfolate 15 mg - 90 Capsules for a few weeks now and have noticed a significant improvement in our mood and energy levels. This supplement is easy to take and does not contain any fillers, soy, gluten, dairy, eggs, or nuts.

One of the things we like about this supplement is that it is the only form of folate to cross the blood-brain-barrier, which makes it ideal for supporting brain health. Additionally, the fact that it contains no fillers or binders means that you are getting a pure and potent dose of methylfolate.

While this supplement is more expensive than some other options on the market, we believe that the quality and effectiveness make it worth the investment. If you are looking for a high-quality methylfolate supplement to support your overall health and well-being, we highly recommend MethylPro L-Methylfolate 15 mg - 90 Capsules.

Buying Guide

When choosing a methylfolate supplement, there are a few key factors to consider to ensure you are getting the best product for your needs. Here are some things to look for:

Dosage

The first thing to consider is the dosage. Methylfolate supplements come in a range of dosages, from 400mcg to 5mg or more. It's important to choose a dosage that is appropriate for your individual needs, as taking too much can lead to unwanted side effects. We recommend consulting with a healthcare professional to determine the appropriate dosage for you.

Form

Methylfolate supplements come in various forms, including tablets, capsules, and powders. The form you choose may depend on your personal preference, as well as any dietary restrictions you may have. For example, if you are vegan, you may want to choose a capsule or powder that is free of animal products.

Quality

When it comes to supplements, quality is key. Look for a product that is made by a reputable manufacturer and has been independently tested for purity and potency. You may also want to choose a product that is certified by a third-party organization, such as NSF International or USP, to ensure it meets strict quality standards.

Price

While price should not be the only factor you consider when choosing a methylfolate supplement, it is important to find a product that fits within your budget. Keep in mind that higher-priced products may not necessarily be of higher quality, so do your research and compare prices before making a purchase.

Other Considerations

In addition to the factors listed above, there are a few other things to consider when choosing a methylfolate supplement. For example, you may want to choose a product that is free of common allergens, such as gluten, soy, and dairy. You may also want to look for a product that contains other beneficial ingredients, such as vitamin B12 or magnesium.

Overall, choosing the best methylfolate supplement for your needs requires careful consideration of the dosage, form, quality, price, and other factors. By doing your research and consulting with a healthcare professional, you can find a product that will support your overall health and well-being.

Frequently Asked Questions

What is the recommended dosage of methylfolate for MTHFR?

The recommended dosage of methylfolate for MTHFR varies depending on the individual's needs. It is best to consult with a healthcare professional to determine the appropriate dosage for you.

What are the benefits of taking a 5-MTHF supplement?

5-MTHF supplements can help support healthy methylation, which is important for DNA synthesis, neurotransmitter production, and many other vital processes in the body. It may also support healthy fetal development during pregnancy.

What are the differences between 5-MTHF and folic acid supplements?

5-MTHF is the active form of folate that the body can readily use, while folic acid needs to be converted to 5-MTHF before the body can use it. Some people may have difficulty converting folic acid to 5-MTHF, making 5-MTHF a better option for them.

What are the best sources of folate in food?

Some of the best sources of folate in food include leafy green vegetables, beans, lentils, avocados, and fortified cereals. However, some people may have difficulty absorbing folate from food sources, making a supplement a better option.

What are the benefits of taking a methylfolate supplement?

Methylfolate supplements can help support healthy methylation and provide a readily available source of folate for those who have difficulty absorbing it from food sources. It may also support healthy fetal development during pregnancy.

Are all methylfolate supplements the same quality?

Not all methylfolate supplements are created equal. It is important to choose a high-quality supplement from a reputable manufacturer to ensure purity and potency. Look for supplements that are third-party tested for quality and purity.

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