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Top 10 Best Acetyl-L-Carnitine Supplements to Help Lose Weight

Written by Andrew Le, MD

UpdatedFebruary 29, 2024

Acetyl-L-Carnitine (ALCAR), a derivative of the essential amino acid L-carnitine, has gained significant attention for its potential benefits in exercise performance and weight loss.

Brainy Insights predicts that the market, valued at $182.23 billion in 2020, will likely reach $296.83 billion by 2030. North America led the market in 2020, holding a 34.4% share of the market revenue.

If you're considering adding Acetyl-L-Carnitine supplement to your lineup, this article will review 10 options to assist you in choosing the best fit. We'll discuss factors such as benefits, pros, cons, and more, offering a detailed guide for making an informed decision.

Understanding Acetyl-L-Carnitine

Acetyl-L-Carnitine, commonly referred to as ALCAR, is an amino acid naturally synthesized in the body. Its key function is facilitating the metabolism of fatty acids, the primary energy source for our bodies.

Acetyl-L-Carnitine is crucial for the optimal functioning of vital organs such as the heart, brain, and muscles. Studies show that Acetyl-L-Carnitine, especially in its role concerning the brain, may provide potential benefits for individuals with neurodegenerative diseases.

Benefits of Acetyl-L-Carnitine for Weight Loss

Nutrient supplements serve a broad spectrum of health needs, and among them, Acetyl-L-Carnitine stands out as a versatile solution with numerous benefits.

Let’s take a look at these benefits below.

Physical Performance

As we age, maintaining physical strength becomes crucial for daily tasks and injury prevention. Acetyl-L-Carnitine aids in muscle mass preservation and boosts energy levels, facilitating easier and more effective exercise.

Improved physical performance contributes to enhanced muscle strength and sustained physical wellness.

Muscle Recovery

For fitness enthusiasts, muscle recovery is essential. Adding acetyl-L-carnitine into your routine supports quicker recovery by increasing blood flow to muscle tissue. This improved circulation helps repair exercise-induced damage, ensuring a faster recuperation process.

Fatigue Management

Fatigue can significantly impact daily life, causing dizziness, upset stomach, and concentration difficulties. Acetyl-L-Carnitine combats fatigue symptoms by enhancing mitochondrial energy output.

Studies demonstrate its potential in alleviating chronic fatigue symptoms, providing more energy and better sleep quality.

💡 Did You Know?

Acetyl-L-Carnitine supplements might offer relief for multiple sclerosis (MS)-related fatigue, especially in individuals with low blood levels of L-carnitine. In a small study, ALCAR demonstrated better efficacy than medications like amantadine. However, additional studies haven't provided conclusive results yet. While indicating a potential benefit for MS-related fatigue, the findings didn't reach statistical significance.

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Improved Insulin Sensitivity

Researchers found that Acetyl-L-Carnitine improves insulin sensitivity and glucose tolerance in individuals with a low glucose disposal rate (GDR).

This improved insulin sensitivity may prevent the excessive conversion of glucose into fat, potentially supporting weight management. Additionally, enhanced insulin sensitivity can contribute to better overall metabolic health.

Having gained insights into the weight loss benefits of Acetyl-L-Carnitine, let's shift our focus to explore the top Acetyl-L-Carnitine supplements available in the market.

Top 10 Best Acetyl-L-Carnitine (ALC) Supplements For Weight Loss

Selecting Acetyl-L-Carnitine supplements for weight loss may pose a challenge. We've dedicated significant effort to researching and curating a comprehensive list of the highest-quality ALCAR options to assist you.

Our evaluation includes:

  • Potency and efficacy
  • User feedback and reviews
  • Price considerations
  • Potential side effects

If you're looking for the best acetyl-l-carnitine for weight loss, check out our top recommendations below!

See prices for Nutricost Acetyl-L-Carnitine on Amazon

Nutricost's acetyl-l-carnitine capsules is your go-to solution for dependable energy support. Packed with 500mg per serving and 180 servings per bottle, this non-GMO, gluten-free solution seamlessly fits into your daily routine.

Manufactured in a facility compliant with Good Manufacturing Practices (GMP) and registered with the FDA, Nutricost ensures quality manufacturing. This commitment guarantees your peace of mind with every capsule.


  • Users have observed that the supplement has made weight loss more manageable.
  • Individuals with neuropathy have reported finding relief through its use.
  • Ensures safety with non-GMO, gluten-free, and third-party testing.
  • Manufactured in an FDA-registered, GMP-compliant facility.
  • Comes in unflavored and easy-to-swallow capsules.


  • It is only offered in a 180-serving bottle, which may be a drawback for those seeking a smaller quantity, such as a 50-serving option for a trial.
  • Several users have mentioned experiencing headaches following the consumption of the supplement.
See prices for Jacked Factory Acetyl-L-Carnitine on Amazon

Jacked Factory acetyl-l-carnitine stands out as a powerful supplement, delivering a substantial 750mg of acetyl-l-carnitine in each capsule. This concentration ensures a potent and impactful dosage, offering maximum benefits.

Beyond its physical advantages, Jacked Factory acetyl-l-carnitine elevates motivation and reduces brain fog for enhanced cognitive function. This supplement becomes a versatile addition to your routine, supporting both physical and mental well-being.

Jacked Factory takes pride in purity, presenting a supplement free from fillers, magnesium stearate, or food dyes.

🎉 Fun Fact

Magnesium stearate serves as a lubricating agent in supplement, pharmaceutical, and food production. Its main role is to prevent ingredients from sticking to manufacturing equipment.

Although generally considered safe by regulators, magnesium stearate has been a topic of discussion in the health and wellness community.


  • Crafted in a cGMP facility.
  • Higher dosage of acetyl-l-carnitine.
  • Suitable for vegans and vegetarians.
  • Free from fillers, magnesium stearate, and food dyes.
  • Users have reported high satisfaction, stating that it aided in an energy boost and resulted in shedding a few pounds within weeks.
  • Some users experienced an improvement in mental focus.


  • Available only in a 120-serving bottle, which may be limiting for those interested in a smaller trial size.
See prices for NaturaLife Labs Acetyl-L-Carnitine on Amazon

NaturaLife Labs Acetyl-L-Carnitine delivers an impressive 750 mg per capsule, making it one of the most potent formulas available on the market. It’s made with 100% pure acetyl-l-carnitine, ensuring superior quality without the use of fillers or binders.

This supplement takes pride in its premium quality, supporting natural energy production, sports nutrition, and memory/focus.

Additionally, NaturaLife Labs produces its acetyl-l-carnitine in an FDA-registered facility in accordance with Good Manufacturing Practices (GMP), ensuring the trustworthiness and reliability of their supplement.


  • #1 best seller in Amazon’s Sports Nutrition L-Carnitine Supplements category.
  • Suitable for vegans and vegetarians.
  • Promotes fat metabolism, memory & focus, and healthy mood.
  • Does not contain gluten, corn, soy, sugar, milk, eggs, shellfish, and peanuts.
  • Easy to swallow capsules.
  • Several users have noted weight loss, particularly in the stomach/belly area.
  • Numerous users have reported experiencing an energy boost, particularly beneficial for workouts.
  • It provides an optimal dosage which eliminates the need for taking multiple capsules per day.


  • Some users may experience common side effects like stomach upset, nausea, and dry mouth.
See prices for NOW Acetyl-L-Carnitine on Amazon

NOW Acetyl-L-Carnitine is a reliable dietary supplement designed to enhance cellular energy, promote optimal brain and nerve cell function, and offer support for weight loss. Each capsule contains 500mg of acetyl-l-carnitine, which plays a vital role in transporting fatty acids. This helps convert them into cellular fuel, specifically ATP, within the mitochondria.

This supplement is kosher, non-GMO, and soy-free, making it a versatile choice for those with specific dietary needs. Additionally, NOW Acetyl-L-Carnitine is available in four packaging options – 50, 100, 200, and 360 capsules, providing flexibility to suit individual preferences and usage needs.


  • NOW is a trusted and established brand.
  • Kosher, non-GMO, and soy-free.
  • GMP quality assured.
  • Capsule is easy to swallow.
  • Users have noted an increase in energy levels and enhanced mental focus.
  • Several users with diabetic neuropathy have reported that it helps alleviate pain.


  • Some users have mentioned experiencing insomnia and an elevated resting heart rate after taking the supplement.
  • A few users have observed that the supplement's effects are not sustained for the entire day.

📖 Definition

ATP stands for Adenosine Triphosphate. It is a molecule that serves as a primary source of energy for cellular processes in living organisms. ATP is often referred to as the "energy currency" of the cell because it stores and releases energy as needed.

See prices for Double Wood Acetyl-L-Carnitine on Amazon

Discover the flexibility of Double Wood Supplements Acetyl-L-Carnitine, offering a dosage to suit your needs. With a base dosage of two 500mg capsules, manufacturer recommendations suggest an optimal range of 2-4 capsules daily, not exceeding six capsules (3000 mg) to avoid potential adverse effects.

This dosing range allows users to start conservatively and adjust according to personal tolerance and preferences.

Double Wood crafts its acetyl-l-carnitine capsules to supercharge mitochondria, promoting energy production and enhancing workout endurance. Additionally, each capsule actively supports memory, learning, and overall cognitive health.


  • Users reported rapid and noticeable benefits, including significant increases in endurance and stamina during resistance training.
  • Dosing range allows for customization based on personal preferences and tolerance.
  • Manufactured and tested for microbes and heavy metals in the USA.
  • Non-GMO and gluten-free.
  • Easy to swallow.


  • Not suitable for vegans/vegetarians.
  • Only available in one size (150 capsules), limiting options for trial purposes.
  • Multiple users have mentioned receiving the product with broken capsules that stick together.
See prices for Divine Bounty Acetyl-L-Carnitine on Amazon

Divine Bounty acetyl-L-carnitine stands out with its superior potency, providing one of the highest concentrations on the market at 600 mg per capsule, ensuring maximum benefits.

Their formula boasts quality ingredients, free from harmful additives.

Additionally, Divine Bounty's acetyl-l-carnitine capsules are GMO-free, soy-free, gluten-free, and devoid of preservatives, stearates, silicone dioxide, or artificial ingredients, ensuring a pure and clean formula that aligns with your wellness goals.


  • Each capsule contains a higher dosage of acetyl-l-carnitine.
  • Suitable for vegans and vegetarians.
  • GMO-free, soy-free, and gluten-free.
  • Crafted without preservatives, stearates, silicon dioxide, or artificial ingredients.
  • Easy to swallow.
  • High user satisfaction rating on Amazon, accompanied by reports of increased energy, enhanced mental concentration, and improved productivity.


  • Only comes in a bottle of 120 capsules, limiting options for trial purposes.
  • Some users mentioned an unpleasant smell and taste.
See prices for SuperiorLabs Acetyl-L-Carnitine on Amazon

Elevate your cognitive performance with SuperiorLabs acetyl-l-carnitine, a natural energy enhancer designed to support memory improvement and focus. This non-GMO supplement mobilizes stored fat, contributing not only to enhanced brain health but also supporting athletic performance, stamina, and cardiovascular well-being. Each capsule delivers 500mg of pure acetyl-l-carnitine in 100% vegetable capsules.


  • Safe from heavy metals, allergens, and pesticides.
  • Suitable for vegans and vegetarians.
  • No magnesium stearate, dioxide, or other additives.
  • Manufactured in 3rd party-certified NSF facilities.
  • Offers a hassle-free satisfaction guarantee.
  • Users experienced improved memory.
  • Users observed weight loss results after incorporating the supplement.
  • Enhances energy levels which is great for daily workouts.


  • The product is only available in one size (200 capsules), and some users may prefer other size options for individual needs or trial purposes.
  • Some users noted a noticeable smell and fishy taste.
  • Few users reported the product having a rancid quality despite being within the expiration date.
See prices for Horbaach Acetyl-L-Carnitine HCL & Alpha Lipoic Acid on Amazon

Elevate your routine with Horbaach’s acetyl-l-carnitine & Alpha Lipoic Acid, a super supplement crafted for those seeking an energy boost, antioxidant support, and brain function support. Each capsule packs 400mg of acetyl-l-carnitine and 200mg of alpha lipoic acid for optimal absorption.

Naturally free of gluten, wheat, yeast, milk, lactose, soy, and artificial color and flavoring, this supplement is a trusted choice for those prioritizing quality ingredients. With laboratory-tested superior quality, it's a reliable option to convert fat into cellular energy, promote healthy brain and neurotransmitter function, and enhance cognitive support.


  • Promotes the well-being of the brain and supports neurotransmitter function.
  • Transforms fat into energy at the cellular level.
  • Does not contain gluten, wheat, yeast, milk, lactose, soy, artificial color, and flavoring.
  • Has alpha lipoic acid known for its ability to regenerate other antioxidants.


  • Not suitable for vegans and vegetarians.
  • Comes at a higher cost when compared to other acetyl-l-carnitine supplements with similar dosages.
See prices for Jarrow Formulas Acetyl-L-Carnitine on Amazon

Enhance your mental vitality with Jarrow Formulas Acetyl-L-carnitine, a specialized supplement crafted to boost energy production and metabolic function. Featuring 500 mg of acetyl-l-carnitine per capsule, this vegan-friendly option caters to a diverse range of dietary preferences.

Research and intelligent formulations support this supplement, ensuring you receive the complete benefits of vital vitamins, minerals, and supplements.


  • Suitable for vegans and vegetarians.
  • Does not contain wheat, gluten, soy, dairy, egg, fish, shellfish, peanuts, tree nuts, or sesame.
  • Easy to swallow capsules.
  • Multiple users have reported improved workout performance.
  • Users have reported its effectiveness for weight loss.
  • Amazon’s choice in Acetyl-L-Carnitine Nutritional Supplements.
  • Available in a 60-capsule option, suitable for those who prefer to try the supplement first.


  • One of the most expensive options in our selection.
See prices for Thorne Acetyl-L-Carnitine on Amazon

Thorne Acetyl-L-Carnitine Capsules offer a gluten-free, soy-free, and dairy-free dietary supplement supporting healthy brain function and nerve sensations in the hands and feet.

Packed with 500 mg of acetyl-l-carnitine, this antioxidant benefits the brain and nerves in both upper and lower limbs, and enhances cognitive function and focus. Additionally, it also contributes to healthy sperm count and motility.


  • Amazon’s choice in Acetyl-L-Carnitine Nutritional Supplements.
  • Supports healthy brain function and cognitive focus.
  • Promotes healthy sperm count and motility.
  • No GMOs, artificial preservatives, or common allergens.
  • Suitable for vegans and vegetarians.
  • Users have reported experiencing a clearer mind, weight loss, and an energy boost.


  • Most expensive option in our selection.
  • Some users reported experiencing side effects, including gastrointestinal issues, headaches, brain fog, restlessness during sleep hours, and nausea.

⚠️ Health Warning

Like any supplement, there are certain individuals who should refrain from using ALCAR to prevent potential adverse effects. This group includes:

  • Those with a history of seizures.
  • Individuals diagnosed with hypothyroidism.
  • Those undergoing cancer treatment.

Acetyl-L-Carnitine Supplement Buyer’s Guide

Selecting an Acetyl-L-Carnitine supplement involves a thoughtful approach. Before making a decision, it's important to weigh the following factors below.


Understanding the quantity in each serving is essential. The recommended range for most individuals ranges from 1,500 to 3,000 mg daily. Start with a smaller dose, say 500 to 1,000 mg, and see how it works for you. Note that exceeding a daily intake of 3,000 mg over an extended period poses potential risks of side effects, such as vomiting and diarrhea.


Consider whether the supplement contains only acetyl-l-carnitine or includes additional ingredients. Some products focus solely on acetyl-l-carnitine, which is ideal for avoiding overlapping ingredients when stacking supplements.

However, if you're seeking a more comprehensive approach to health and wellness, supplements with added vitamins and amino acids might be beneficial.

Price Consideration

While it's tempting to opt for the cheapest product, be cautious. Inexpensive options may employ processing techniques that compromise the integrity of the amino acid, resulting in lower acetyl-l-carnitine content than advertised.

Our selection process emphasized a balance between affordability and quality, steering clear of products with potential compromises in manufacturing techniques.

Final Thoughts

Nutricost stands out as the most cost-effective option and a favorite among users. On the other hand, Jacked Factory offers a potent dosage formula, maximizing both physical and cognitive benefits.

NaturaLife Labs excels in premium quality and holds the #1 best-seller position in Amazon’s Sports Nutrition L-Carnitine Supplements category.

NOW provides versatility with various packaging options and reliable support for cellular energy. Lastly, Double Wood offers flexibility in dosing, allowing users to customize intake based on personal preferences and tolerance, making it a versatile choice for individualized health plans.

Whether you prioritize energy support, cognitive function, or weight loss, the diversity in these supplements ensures there's an ALCAR option for everyone. Explore and choose wisely based on your individual requirements. Most importantly, consult with your doctor to determine the suitable dosage for your requirements.

FAQs on Acetyl-L-Carnitine Supplements

How does Acetyl-L-Carnitine (ALCAR) differ from L-Carnitine?

ALCAR is a derivative of the amino acid L-carnitine. The "acetyl" group allows ALCAR to cross the blood-brain barrier more effectively than L-carnitine, making it beneficial for cognitive functions.

Does ALCAR have anti-aging properties?

Some studies suggest that ALCAR's antioxidant properties may contribute to anti-aging effects by protecting cells from oxidative damage and supporting overall cellular health.

Can you take Acetyl-L-Carnitine with other supplements or medications?

ALCAR is often safe to take with other supplements, but interactions with specific medications may occur. Consultation with a healthcare provider is crucial, especially for individuals on prescription medications.

Can you take Acetyl-L-Carnitine supplement on an empty stomach?

Yes, it's often advisable to take ALCAR on an empty stomach for optimal absorption. However, individual tolerance may vary.

Are there any specific dietary recommendations while taking Acetyl-L-Carnitine supplement?

While there are no strict dietary restrictions, maintaining a balanced diet rich in nutrients can complement the effects of ALCAR. It's advisable to consult with a nutritionist.

Illustration of a healthcare provider asking questions on a smart phone.
Virtual weight loss solution
A personalized GLP-1 medication program delivered to you via our partner Korb Health
Illustration of a healthcare provider asking questions on a smart phone.
  • Free consultation; program starts at $269/mo
  • Checkmark Inside Circle.Customized online program and wellness coaching
  • Prescription medications and supplies shipped to your door