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Top 13 Best Probiotic with Digestive Enzymes

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Written by Andrew Le, MD.
Medically reviewed by
Last updated September 26, 2024

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Probiotics are the live microorganisms that when consumed in sufficient amounts are reported to have health improving effects on the consumer. These are naturally present in foods such as yogurt, kefir and sauerkraut, but they can also be bought as dietary supplements. Digestive enzymes are quite the opposite since they are proteins which aid in food digestion by breaking it into smaller particle that can be assimilated by the body. They are synthesized in the pancreas organ but can also be taken as a nutraceutical supplement to support digestion.

When taken together, probiotics and digestive enzymes are one of the best things that you can do for your stomach. New research suggests that taking probiotics assist in balancing the internal gut bacteria, enhance digestion and the immune system. Digestive enzymes on the other hand are known to assist in digestion and may be beneficial in cases of digestive disorders such as bloating, gas and constipation.

When looking for the best probiotic with digestive enzymes it would be wise to look at the strength and number of strains within this product. Another important factor that should be considered is the quality and purity of the ingredients, presence of allergens, or addition of any other extra ingredients.

Through a comprehensive analysis of the available products, we have discovered the best probiotic with digestive enzymes.

Top 3 Best Probiotics with Digestive Enzymes

  1. Bioma
  2. Wild Prebiotics and Probiotics with Digestive Enzymes
  3. S RAW SCIENCE Digestive Enzymes

In this article, we have shared details about the various probiotics with digestive enzymes available for sale on Amazon. It is important to note that we have researched and tried all the products to provide the best to consumers. Whether you are interested in a product that will enhance your digestion or that of your immune system, we have got you covered. Well, let’s go straight to our analysis of the latest probiotics with digestive enzymes on Amazon.

Bioma

The Editor's Choice

Bioma excels at weight control and digestive health. It enhances digestion, boosts nutrient absorption, and prolongs fullness, which aids appetite regulation and improves metabolic health by reducing intestinal inflammation.

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We heartily suggest Bioma as one of the greatest probiotics with digestive enzymes for people looking to improve their digestive health and manage their weight. Important strains of Bifidobacterium breve, longum, and lactis are included in this powerful composition; these strains are well-known for their capacity to help weight loss, aid in digestion, and foster a healthy gut flora.

Pros:

  • Promotes healthy gut flora
  • Helps reduce fat mass and regulate appetite
  • Supports digestive health
  • Aids in weight management
  • Prevents leaky gut syndrome

Cons:

  • Requires consistent use for noticeable results
  • May not work for everyone

Based on our observations, Bioma is excellent in promoting both weight control and digestive health. In addition to enhancing our digestion, the probiotics increased our intake of nutrients and prolonged feelings of fullness, all of which were particularly beneficial for regulating our appetite. Weight control became more successful as a result of improved metabolic health brought on by the decrease in intestinal inflammation. All things considered, Bioma produces outstanding outcomes for people trying to lose weight and strengthen their digestive system.

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If you are looking for a powerful gut health supplement, Wild Prebiotics and Probiotics with Digestive Enzymes is an excellent choice.

Pros

  • Contains 20 billion CFU and 10 probiotic strains
  • Includes digestive enzymes for improved nutrient absorption
  • Non-GMO and made with prebiotic fiber
  • Convenient 30-count packaging
  • Suitable for both men and women

Cons

  • Some may experience mild digestive discomfort initially
  • A bit pricier compared to other options on the market

Wild Prebiotics and Probiotics features a robust blend of 20 billion CFU, encompassing ten different probiotic strains to ensure a diverse microbiome. The digestive enzymes included enhance its effectiveness by breaking down food efficiently, while the non-GMO prebiotic fiber nurtures beneficial bacteria in the gut. Each bottle offers 30 capsules, providing a month’s supply for daily support.

After incorporating these probiotics into our routine, we noticed significant improvements in digestion and gut health. Regular bloating and discomfort decreased, leaving us feeling more energized. The combination of probiotics and digestive enzymes worked seamlessly to promote better nutrient absorption.

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We’ve been on the lookout for effective digestive health supplements, and S RAW SCIENCE Digestive Enzymes with Probiotics truly stands out.

Pros

  • Effective bloating relief
  • Comprehensive enzyme blend
  • Suitable for various dietary needs

Cons

  • May require consistent use for best results
  • Some users may experience initial digestive upset

S RAW SCIENCE Digestive Enzymes is a top-quality product, which comes with lactase and protease digestive enzymes as well as probiotics. This unique blend helps break down food more effectively, making it easier for our bodies to absorb nutrients. The product is in the form of capsules and it contains 60 capsules in each bottle, making it suitable to be consumed daily.

After using S RAW SCIENCE for several weeks, we’ve noticed a significant reduction in bloating and discomfort after meals. The enzymes work harmoniously with the probiotics, enhancing our digestion and gut health. We appreciate the balance of natural ingredients, which feel gentle yet effective.

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If you are experiencing bloating after meals and you are seeking a product that can assist you in reducing this, the Physician’s CHOICE Digestive Enzymes is a good product to consider.

Pros

  • With 16 beneficial enzymes, these capsules can digest proteins, carbs, fruits, veggies, beans, dairy, and fats to cover all diets.
  • The prebiotics and probiotics in this product promote digestive function in the gut, working synergistically with the powerful digestive enzymes to provide dual-action relief.
  • Formulated with three soil-based probiotic strains, this product is designed to survive the harsh gut environment, ensuring that you get the full benefits of the probiotics.

Cons

  • Some users have reported that they experienced uncomfortable bathroom breaks when taking the recommended dose of one capsule with each meal.
  • While this product is vegan-friendly, it may not be suitable for those with certain dietary restrictions or allergies.
  • The probiotics in this product are built into each individual capsule, which may be a downside for some users who prefer to take them separately.

Over the past few weeks, we have been taking Physician’s CHOICE Digestive Enzymes and have found a huge improvement in our digestion and gut health. These capsules can be swallowed whole and do not create any form of irritation or have any side effects. We like that this product is rooted in scientific evidence and is tested for purity and strength by a third party. In sum, we suggest that anyone who wants to introduce enzymes to their daily diet in order to regulate digestion and overcome mealtime complaints should consider purchasing Physician’s CHOICE Digestive Enzymes.

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We recommend Jacked Factory Green Surge as an outstanding choice for those seeking a nutritious green superfood powder. This keto-friendly drink is not only delicious but also packed with beneficial ingredients that support health goals.

Pros

  • Excellent taste for a greens powder.
  • Keto-friendly, making it suitable for various diets.
  • Contains probiotics and digestive enzymes for improved gut health.

Cons

  • Some may find it slightly gritty when mixed.
  • A bit of time may be needed to adjust if new to superfoods.

Jacked Factory Green Surge features a powerful combination of nutrient-dense ingredients. With spirulina, wheat grass, and barley grass at its core, it delivers essential vitamins and minerals. The addition of green tea extract provides an antioxidant boost, while probiotics and digestive enzymes promote gut health and enhance digestion. This thoughtful blend not only supports our overall wellness but also offers a clean energy lift.

After using Green Surge consistently for some time, we noticed increased energy levels and improved digestion. The probiotics helped keep our gut balanced, while the greens offered a wholesome boost.

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When we decided to enhance our digestive health, we turned to the GOBIOTIX Probiotic Supplement with Digestive Enzymes. This supplement stands out for its blend of ingredients designed to support detoxification and gut health.

Pros

  • Powerful blend of probiotics and digestive enzymes
  • Supports detoxification and overall digestive health
  • Easy-to-swallow capsules
  • No artificial additives or fillers

Cons

  • May take time to notice significant effects
  • Some users report mild digestive discomfort initially

GOBIOTIX Probiotic Supplement offers a robust 50 billion CFU per serving, ensuring effective probiotic delivery. It combines beneficial strains with digestive enzymes to aid food breakdown and nutrient absorption. The inclusion of milk thistle promotes liver health, while turmeric and dandelion root support detoxification and reduce inflammation. Each bottle contains 60 easy-to-swallow capsules, making it convenient to incorporate into our daily routine.

After incorporating GOBIOTIX into our regimen, we noticed a marked improvement in digestion and overall gut health. It helped alleviate bloating and discomfort after meals, allowing us to feel lighter and more energized. The detoxifying properties of milk thistle and turmeric contributed to our well-being, making this supplement a valuable addition to our health routine.

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We’ve been using the Sports Research Digestive Enzymes with Probiotics & Ginger, and it’s truly one of the best supplements we've tried for improving digestion.

Pros

  • Combines digestive enzymes, probiotics, and ginger in one capsule
  • Effective for bloating, gas, and discomfort
  • Vegan-friendly and non-GMO
  • Easy-to-swallow veggie capsules

Cons

  • Might take a week or two for noticeable effects
  • May not be suitable for severe digestive issues

The Sports Research Digestive Enzymes with Probiotics & Ginger contains 90 veggie capsules, each packed with enzymes like amylase, protease, and lactase to break down carbs, proteins, and dairy. It also includes probiotics and ginger root, which support gut health and ease digestion naturally. The fact that it’s non-GMO verified and vegan-friendly adds a great benefit for those of us with dietary restrictions. We also appreciate the capsule format, which is convenient for daily use.

We've found it to be highly effective for mild digestive discomfort. After meals, we’ve noticed a significant reduction in bloating and gas, especially after eating dairy or protein-heavy foods. The added ginger helps soothe the stomach, making this supplement a reliable choice for daily digestive support. It’s gentle on the stomach yet effective.

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Purely Optimal Premium Digestive Enzymes Plus Prebiotics & Probiotics has been a game-changer for us in maintaining digestive health.

Pros

  • Effective relief from gas, bloating, and constipation
  • Supports immune health and nutrient absorption
  • Combination of enzymes, prebiotics, and probiotics
  • 180 capsules offer good value for the price

Cons

  • Capsules may be large for some
  • Results vary with long-term use

Purely Optimal Premium Digestive Enzymes Plus Prebiotics & Probiotics features 12 digestive enzymes, including protease, amylase, and lipase, which help break down proteins, carbs, and fats. The added prebiotics nourish gut bacteria, while the probiotics (10 billion CFU) help restore balance in the digestive system. It also includes ingredients like papaya, ginger, and turmeric, known for their soothing effects on digestion. The 180 capsules provide a one-month supply when taken as directed (two capsules per serving).

We’ve noticed a significant improvement in digestion and reduction in bloating after meals. The combination of enzymes and probiotics seems to work well in tandem, helping us feel lighter and more comfortable. The added prebiotics are a nice touch, ensuring that the probiotics thrive in the gut.

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If you’re looking for a complete solution to support your gut health, ONNIT Total Gut Health is a standout option.

Pros

  • Comprehensive blend of probiotics, prebiotics, and enzymes.
  • Single-serving packets, perfect for travel.
  • Betaine HCL enhances digestion for those with low stomach acid.
  • No refrigeration needed.

Cons

  • Higher price point compared to basic probiotics.
  • Betaine HCL may not suit everyone, especially those sensitive to acid.

ONNIT Total Gut Health features a potent combination of five probiotic strains, which help balance gut flora, and digestive enzymes, which aid in breaking down proteins, carbs, and fats more efficiently. The added Betaine HCL supports optimal stomach acidity, improving overall digestion. Each packet is pre-measured for convenience and travel, with no need for refrigeration, making it a great option for those with busy lifestyles.

We found ONNIT Total Gut Health to be highly effective in reducing bloating and discomfort, especially after large meals. The combination of probiotics and enzymes noticeably improved digestion, making it easier to process different foods. For those with low stomach acid, the Betaine HCL was a great benefit, though individuals sensitive to acid may need to proceed with caution.

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For a good digestive supplement, the Zenwise Health Digestive Enzymes is a good choice worth giving a shot.

Pros

  • The combination of pre and probiotics, digestive enzymes, and botanicals makes this a comprehensive digestive supplement.
  • The De111 probiotic strain is clinically proven to be effective and reliably alive.
  • The 180 serving supply makes this a good value for the price.

Cons

  • Some users have reported negative side effects such as increased bloating and constipation.
  • The capsules may be difficult to swallow for some users.
  • The supplement may take some time to start working and show results.

We have been taking Zenwise Health Digestive Enzymes for quite some time now and it has served us well in controlling occasional flatulence and discomfort. Therefore, this is a comprehensive digestive supplement that contains pre and probiotics, digestive enzymes, and botanicals to enhance the gut and immune system functions.

We acknowledge the fact that the De111 probiotic strain is safe for human consumption and this is clinically effective and alive, this gives confidence that consuming the supplement is the best way to go. The 180 serving supply also makes this a good value for the price, meaning that we do not need to order as often.

Nevertheless, some users have complained of side effects such as increased cases of bloating and constipation. Furthermore, the capsules may not be very appealing to users since some may find it hard to swallow capsules. It is also worthy of note that the supplement may not become effective immediately and thus may take time before the first effects of the new digestive supplement can be seen.

In conclusion, we would recommend Zenwise Health Digestive Enzymes to any person interested in a powerful digestive supplement that enhances gut and immune health. Like with any other supplement it is always recommended to seek medical advice from a doctor before beginning a new course.

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If you want a digestive supplement that offers quick solution, Wholesome Wellness Digestive Enzymes could be the perfect match for your needs.

Pros

  • This supplement contains a powerful 1000 MG dose of clinical-grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics, making it a complete digestive solution.
  • Wholesome Wellness Digestive Enzymes is formulated using organic, systemic, Dr. formulated, and plant-based ingredients to ensure the best healthy digestion for adult men and women.
  • This supplement contains prebiotic fiber, probiotic encapsulation, and enzymes that support gut flora bacteria, bile, nutrient absorption, motility, and enzyme levels your body isn't producing as you age.

Cons

  • Some users may experience discomfort in the initial period of use, and it may take a few days to get used to the supplement.
  • The product may not be suitable for people with certain allergies or dietary restrictions.
  • The price point of Wholesome Wellness Digestive Enzymes is higher than some other digestive supplements on the market.

Wrapping up, Wholesome Wellness Digestive Enzymes is a good choice for those willing to enhance the quality of their digestion. The supplement is very convenient to use, and the plant-derived ingredients do not cause any negative side effects such as indigestion. We are thankful that the product is completely vegan, non GMO, completely pure natural, contains no gluten, is cGMP wise, dairy free, zen and completely organic and contains no soy, peanuts, eggs, gelatin, ox, shellfish, artificial sweeteners, colors or flavors.

They offer a complete digestive solution that they claim can help ease gas, bloating, constipation, leaky, indigestion, reflux, burping, and acid problems.

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Carlyle Digestive Enzymes may prove to be quite helpful if you are seeking for a simple approach to boost your digestive well-being.

Pros

  • Get full-spectrum digestive support from a range of enzymes, probiotics, and prebiotics.
  • Simply take two capsules before or after meals for maximum support.
  • Carlyle provides premium, honest supplements in your pursuit of healthy living.

Cons

  • Some customers report that the potency of these probiotics is not as strong as other top-of-the-line options.
  • If you have heartburn or acid reflux, you may want to avoid these digestive enzymes.
  • It may take some time to determine if these enzymes are actually doing anything for your digestive health.

In a nutshell, we have discovered that Carlyle Digestive Enzymes are among the best aids for supporting the digestive system. We understand that they include several enzymes, probiotics, and prebiotics to offer comprehensive support. Also, it is very easy and convenient to take two capsules as a serving size before or after the meals.

However, some of the customers have complained that these probiotics are not as effective as other premium brands. Furthermore, if you suffer from heartburn or acid reflux, then it is advisable to avoid these digestive enzymes. Last but not least, it may take some time before you will get conclusive evidence whether these enzymes really provide anything to your stomach’s health, so do not give up on them and keep on taking them.

All in all, we believe that Carlyle Digestive Enzymes are a good choice for people planning to improve their digestion in a hassle-free manner.

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If you feel that you have poor digestion and weak gut health, then Life Extension Enhanced Super Digestive Enzymes & Probiotics is suitable for you.

Pros

  • This supplement contains ten types of digestive enzymes, including alpha galactosidase, protease 3.0, and lipase, which can help you digest proteins, fats, and hard-to-digest veggies, legumes, leafy greens, and fruit.
  • The probiotic strand B. coagulans in the formula supports digestion health and suppresses less-beneficial bacteria, promoting digestive comfort.
  • The product is sourced using only the finest raw ingredients with the purity and potency your body deserves. It is certified non-GMO and manufactured in the USA.

Cons

  • Some users may experience side effects such as gas or bloating when they first start taking the supplement.
  • The product may not be suitable for people with certain medical conditions or those taking certain medications.
  • The supplement may not work for everyone, and results may vary depending on individual factors.

The Life Extension Enhanced Super Digestive Enzymes & Probiotics is a great supplement for anyone trying to better themselves in the digestive system. It has a list of ten digestive enzymes which includes alpha galactosidase and protease 3. 0, lipases which aid in the digestion of proteins, fats and other complex foods such as vegetables, beans, nuts and fruits among others. The strand used as the probiotic in the product is B. coagulans that aids in digestion health and discourages the growth of less helpful bacteria to ensure digestion ease.

The supplement is sourced from the best ingredients that have the ability to deliver the purity and potency that the body requires. It is non-GMO certified and is made in USA. Nonetheless, some users may suffer from side effects including gassiness or bloating immediately the moment they start taking the supplement. The uses of the product should be restricted for people with particular health conditions or those using particular drugs. Also, not everyone may benefit from the supplement, and there can be variations in the outcome due to certain conditions.

In conclusion, Life Extension Enhanced Super Digestive Enzymes & Probiotics is a good product especially for people who wish to enjoy a healthy digestion. It seems that the product is an excellent choice if you need a supplement that contributes to absorption of nutrients from the foods and offers a sense of relieved digestion.

Buying Guide

If you are to choose a specific probiotic with digestive enzymes, there are certain factors you need to take into consideration so that you can get the very best.

Strain Diversity

The best probiotic must have a wide strain-count for it to be beneficial to the consumer’s digestive system. When considering the products, opt for those that have incorporated several strains such as the Lactobacillus and Bifidobacterium strains.

Enzyme Variety

Besides the probiotic strains, a good product should also have the blend of various enzymes for digestion of various types of foods. Enzymes such as amylase, protease, and lipase should also be on the list of ingredients.

Potency and CFU Count

The effectiveness of any probiotic depends on the number of CFUs it has to offer. When choosing a product, it is advised to seek those with the highest Standard Plate Count or CFU as it translates to effectiveness. But bear in mind that the higher the number is, the better is not always true – a product with a CFU higher than another might be less effective due to the lower number of strains.

Shelf Stability

Given that probiotics are living organisms, they are sensitive to things such as heat and moisture. Another consideration is focusing on the products that are not refrigerated, as they can be more easy to carry and may be fresher longer.

Other Considerations

If you are to choose a probiotic with digestive enzymes, other factors to consider include whether you have certain medical conditions such as IBS or lactose sensitivity. It is also advisable to read labels of the product so as to determine whether you are allergic to any given product.

When these factors are considered then one can select a probiotic with digestive enzymes for their digestive program effectively.

Frequently Asked Questions

What are the benefits of taking probiotics with digestive enzymes for weight management?

Probiotics and digestive enzymes work together to support healthy digestion and nutrient absorption, which can lead to improved weight management. Probiotics help to balance the gut microbiome, which can affect metabolism and weight. Digestive enzymes aid in breaking down food and making nutrients more available for absorption. Together, they can improve digestion and help maintain a healthy weight.

Can you take probiotics and digestive enzymes simultaneously for optimal gut health?

Yes, you can take probiotics and digestive enzymes together to support optimal gut health. Probiotics help to balance the gut microbiome, while digestive enzymes aid in breaking down food and improving nutrient absorption. When taken together, they can help improve digestion and support overall gut health.

What are the top-rated probiotic supplements that include digestive enzymes?

Some top-rated probiotic supplements that include digestive enzymes are Garden of Life RAW Probiotics Colon Care, Renew Life Ultimate Flora Extra Care Probiotic, and Zenwise Health Digestive Enzymes Plus Prebiotics & Probiotics.

Are there any specific groups of people who should avoid taking digestive enzymes?

While digestive enzymes are generally safe for most people, those with certain medical conditions such as pancreatitis or liver disease should consult with a healthcare provider before taking digestive enzymes. Additionally, those who are pregnant or breastfeeding should also consult with a healthcare provider before taking digestive enzymes.

What can one expect when beginning a regimen of digestive enzymes with probiotics?

When beginning a regimen of digestive enzymes with probiotics, one can expect improved digestion and nutrient absorption, which can lead to improved overall health. Some people may experience mild digestive discomfort or bloating initially, but this should subside as the body adjusts to the new regimen.

Have there been any recalls on popular brands like Zenwise for their digestive enzyme products?

We are not aware of any recalls on popular brands like Zenwise for their digestive enzyme products. However, it is important to always check for any recalls or safety concerns before purchasing any supplement.

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The links provided may earn us a small commission at no additional cost to you if you choose to purchase the recommended product. This support allows our research and editorial team to continue providing high-quality recommendations. As a participant in the Amazon Services LLC Associates Program, an affiliate advertising initiative, we are able to earn advertising fees through providing links to products on Amazon.com. Please rest assured that we only recommend high-quality products.

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Jeff brings to Buoy over 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medi...
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