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Top 10 Best Glycine Supplements

Written by Andrew Le, MD

UpdatedOctober 23, 2024

Glycine is one of the amino acids that are classified under nonessential amino acids since the body can synthesize it by itself. This essential amino acid can be produced in the human body and is involved in production of collagen, creatine and various neurotransmitters. It is also a glycine precursor to glutathione, the body’s ultimate antioxidant that is a vital support for the body’s immune system. However, glycine is endogenous to the body and can also be synthesized, supplementing with glycine has additive effects.

Top 3 Best Glycine Supplements

  1. Nutricost Glycine Powder 1lb
  2. Double Wood Glycine Supplement
  3. Life Extension Glycine Supplement

Below we provide information about different types of glycine supplements that we have considered and the ones that we recommend. Glycine is one of the twenty amino acids that are present in all body tissues and is the smallest amino acid in the body and is important in the formation of collagen that is vital in skin and joint development. It also relieves the mind and is taken as an aid to helping to use to control anxiety and insomnia.


Nutricost Glycine Powder 1lb

Editor's Choice

Nutricost Glycine Powder 1lb

Nutricost Glycine Powder 1lb offers pure, non-GMO, gluten-free glycine, perfect for our dietary needs. Its versatility lets us mix it into drinks or food easily. We’ve experienced better sleep, cognitive function, and relaxation. Despite a slightly bitter taste, it’s cost-effective and lab-tested for purity and potency.

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We've been searching for a high-quality glycine supplement, and Nutricost Glycine Powder 1lb has proven to be one of the best options on the market. This supplement stands out for its purity, effectiveness, and value, making it a fantastic addition to our wellness routine.

Pros

  • High purity and quality
  • Non-GMO and gluten-free
  • Versatile and easy to mix
  • Cost-effective

Cons

  • Slightly bitter taste
  • Needs accurate measurement

Nutricost Glycine Powder 1lb is made from pure glycine, ensuring we get the highest quality amino acid. It is non-GMO and gluten-free, which aligns with our dietary preferences. The powder form allows for versatility in usage; we can easily mix it into our drinks, smoothies, or even sprinkle it over food. The 1lb packaging provides a generous supply, making it a cost-effective choice for long-term use. The product is lab-tested for purity and potency, giving us confidence in its efficacy.

We've noticed significant improvements since incorporating Nutricost Glycine Powder into our daily regimen. Glycine has helped us with better sleep quality, enhanced cognitive function, and overall relaxation. The powder dissolves quickly in both cold and hot beverages, although the taste can be slightly bitter, so we often mix it with flavored drinks to mask it. Accurate measurement is essential to avoid consuming too much, but with the right tools, this becomes a minor inconvenience.


Double Wood Glycine Supplement

Double Wood Glycine Supplement

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In our quest for the best glycine supplement, we discovered the Glycine Supplement by Double Wood. With 1,000mg of glycine powder per serving and 300 capsules per bottle, this supplement stands out for its quality and efficacy. Marketed as "The Relaxing Amino Acid," it's third-party tested, gluten-free, and non-GMO, making it a reliable choice for enhancing sleep and overall well-being.

Pros

  • High potency with 1,000mg per serving.
  • 300 capsules provide long-lasting supply.
  • Third-party tested ensures purity and quality.
  • Gluten-free and non-GMO, suitable for various dietary needs.
  • Promotes relaxation and better sleep.

Cons

  • Capsules may be large for some to swallow.
  • Effects on relaxation may vary between individuals.

The Glycine Supplement by Double Wood features a potent 1,000mg of glycine powder per serving, encapsulated in 300 easy-to-take pills. The product is rigorously third-party tested, ensuring each capsule meets high standards of purity and quality. Additionally, it is gluten-free and non-GMO, catering to diverse dietary preferences. The supplement is designed to enhance relaxation and support better sleep, making it a valuable addition to our wellness regimen.

From our experience, this glycine supplement delivers on its promise of promoting relaxation and improving sleep quality. We noticed a significant reduction in nighttime awakenings and felt more refreshed in the morning. The high dosage per capsule means fewer pills to take, which is convenient. Despite the capsules being slightly large, they are easy to incorporate into our daily routine. The quality assurance from third-party testing gave us confidence in its purity and effectiveness.


Life Extension Glycine Supplement

Life Extension Glycine Supplement

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Therefore, we highly endorse the Life Extension Glycine Supplement since it aids in relaxation, Sleep sugar, glucose, and fructose metabolism.

Pros

  • The supplement is formulated with 1000mg of glycine, which is a significantly higher dose than many traditional glycine supplements, to provide maximum benefits.
  • Glycine promotes healthy sleep without causing daytime drowsiness.
  • Glycine has additional whole-body health benefits and has been shown to impact mood, cognition, and mental health positively.

Cons

  • The product may not work for everyone.
  • Some users may experience mild side effects such as nausea or headaches.
  • The capsules may be difficult to swallow for some people.

In fact, I want to note that we have been using the Life Extension Glycine Supplement for several weeks at all and the quality of sleep has improved greatly. Due to the supplement working on the brain, this makes one to have a easier time to sleep than before and also stay such a sleep without having to wake up at any time during the night. We also like that the product is Non-GMO and gluten free certified Besides, the manufacturer delivers a Certificate of Analysis of the product that they produce.

Aside from the improvement in the quality of sleep, I have also observed that the supplement has made me and my wife feel more relaxed in the daytime and even in other aspects in our life. We have not observed any adverse effects while taking the product and we felt it necessary to continue using it as a supplement to our body’s nutritional needs.

In conclusion, if you are planning to purchase a high-quality glycine supplement that helps with sleep issues and other whole-body health benefits, approaching the Life Extension Glycine Supplement is advisable.


NOW Supplements Glycine Pure Powder

NOW Supplements Glycine Pure Powder

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NOW Supplements Glycine Pure Powder is a great source of glycine if you’re in search of a supplement for restful sleep and to help support the nervous system.

Pros

  • Pure powder
  • Promotes restful sleep
  • Neurotransmitter support

Cons

  • Exposure to heat or sunlight may lead to melting/damage of product
  • May not be effective for everyone
  • Large pills may be difficult to swallow

We have made a switch to NOW Supplements Glycine Pure Powder and have eagerly been incorporating it for the last few weeks with positive results for our sleep. The reconstitution of the powder with water or juice is not a problem, and the product does not leave any aftertaste. It is also helpful to see that it is non-GMO, soy free, and vegan which are all great details to have on any product.

Another thing to consider is that heat or sunlight is not good for the product, for example it may melt, so it may be necessary to be home during the delivery time. Furthermore, while glycine can help in sleep aid and to support the nervous system, this may not always be the case because it may not effective in all patients.

All in all, it can be wisely suggested NOW Supplements Glycine Pure Powder to anyone interested in getting a high-quality glycine supplement that regulates sleep/wake cycle and helps the nervous system.


BULKSUPPLEMENTS.COM Glycine Powder

BULKSUPPLEMENTS.COM Glycine Powder

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We highly recommend BULKSUPPLEMENTS. It is recommended for consumers seeking amino acid in its purest, finest, gluten-free form through COM Glycine Powder.

Pros

  • Easily add to your diet for an extra boost of protein and amino acids
  • Suitable for everyone regardless of dietary restrictions
  • Third-party tested multiple times throughout production

Cons

  • Some users may not like the taste of the powder
  • May cause mild stomach discomfort if taken in large doses
  • May not dissolve completely in water

BULKSUPPLEMENTS.COM is designed to serve as an excellent source of the vital amino acid Glycine, Glycine Powder is perfect for replenishing your glycine levels. Again, taking a 3000mg serving of this powder may benefit the synthesis of proteins in the body particularly creatine and glutathione. Further, glycine may enhance your immunity and can be useful in general regulation of your health and body conditions.

Another advantage of this supplement is that it is neutral: you can take it whether you are a vegetarian, following a Paleo diet, or have any food allergies. It is a gluten-free product, the dairy-free one, and soy free, and they do not add sugar into it. Also, it is versatile to incorporate into the daily diet and can be easily put into your daily breakfast or even dinner in form of smoothies or shakes.

The only negative of this product is that some of the users may find the taste of the product in powder form non-desirable. Also, its large doses could bring about slight gurgles in the stomach and the powder forms may not dissolve well in water.

In conclusion, BULKSUPPLEMENTS is one of the best places to buy supplements online as they offer quality products at a reasonable price. For individuals and athletes who seek for a high potency, gluten-free, and untainted glycine supplement, Optimal Nutrition Glycine Powder can be recommended.


Thorne Glycine - Amino Acid Support for Relaxation

Thorne Glycine - Amino Acid Support for Relaxation

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Thorne Glycine is a premium glycine supplement that doesn’t contain any filler ingredients or preservatives.

Pros

  • Thorne Glycine promotes relaxation for healthy stress management.
  • Necessary for detoxification.
  • Helps modulate cytokine levels in the body.

Cons

  • May cause apathy if overused.
  • Some people may experience a paradoxical effect where it stimulates them instead of calming them down.
  • Unflavored.

I have also had the chance to try out Thorne Glycine for the past few weeks, and at least this has reduced my sleeping problems. It assists us to calm down and go to sleep faster.. We also like that it is made with the most wholesome and natural ingredients possible, and does not include certain like gluten, soy, dairy, shellfish, or fish.

Thorne is known as the market-leading supplement brand that is loved by thousands of health-care professionals, U. S. National Teams, the Mayo Clinic, and families from all around the world. We suggest that Thorne Glycine would be ideal for anyone who needs glycine supplements that support the receptor-, detoxification-, and muscle-related functions as well as enhancing relaxation.


NOW Glycine Supplement

NOW Glycine Supplement

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We can confidently recommend NOW Glycine Supplement for purchase as it is among the best when it comes to quality and function.

Pros

  • Promotes restful sleep and supports the nervous system
  • Pharmaceutical grade and free-form
  • GMP Quality Assured

Cons

  • May cause mild stomach discomfort if taken on an empty stomach.
  • Some users may experience vivid dreams.
  • Natural color variation may occur in this product.

Now, let me share with you our experience of using the NOW Glycine Supplement for several weeks, and we have seen a dramatic enhancement to our sleep. It means that we are able to sleep better without struggling to fall asleep, and that our bodies are able to get a deeper and more restful sleep than we are used to. It is also important to note that this supplement does not contain any traces of animal derivatives; it is vegan formulated and does not contain any of the most popular allergens like gluten, casein, dairy, or soy.

Swallowing the capsules is very discreet and the capsules themselves do not leave behind a bitter or unpleasant aftertaste which is common with other capsules. Some of the side effects of this herbal medicine include a feeling of nausea when taken empty stomach but this is rarely reported. This problem seems to stem from the consumption of the supplement on an empty stomach and we would suggest to combat this take the supplement with a meal.

In conclusion, based on the analysis of the present NOW Glycine Supplement, we find that it is the best product for individuals who wish to enhance the quality of their sleep besides boosting the functionality of the nervous system. The product is of high quality, has an excellent affordable price, and is produced by a company with vast experience as a natural products company, which enriches healthier lifestyles.


NOW Supplements NAC with Selenium & Molybdenum

NOW Supplements NAC with Selenium & Molybdenum

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For anyone seeking a good glycine supplement, we highly suggest the NOW Supplements NAC with Selenium & Molybdenum.

Pros

  • Provides free radical protection and maintains cellular health.
  • Contains essential trace minerals that facilitate the production of several important enzymes.
  • Certified non-GMO, vegan/vegetarian, and made without gluten.

Cons

  • Black speckling may occur over time after the package is opened.
  • The product has an unpleasant smell due to its sulfur-containing amino acid content.
  • The product may arrive warm during summer months.


This NOW Supplements NAC with Selenium & Molybdenum supplement was effective in supporting the standard of living of cells. The nutritional attributes here are for the product to be non-GMO, free from meat products– that is, vegan or vegetarian, and free from any traces of gluten.

Some of the issues reported with the product include speckling which appears black after the package is opened for using but the product is safe for consumption. He also suggested that the product has a lot of smell and this is due to contents of sulfur-containing amino acid. But, in some cases, after opening, when it is impossible to completely eliminate the dessicant and charcoal packets in the bottle, the oxidation process will take longer, and if there was a smell, it could be regulated.

In summary, we think that the NOW Supplements NAC with Selenium & Molybdenum will be a good buy for the glycine supplement.


Toniiq Glycine Supplements

Toniiq Glycine Supplements

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Overall, we would like to endorse the Toniiq Glycine Supplements as a well-made glycine supplement that can be taken by people who wish to improve their sleeping patterns and/or nervous system.

Pros

  • Toniiq Glycine Supplements contain the highest dosage of glycine available on the market for the greatest value.
  • The glycine in Toniiq Glycine Supplements is highly purified, with a minimum purity level of 98.5% in every serving.
  • Toniiq Glycine Supplements set a new standard for purity, with each batch tested for quality and purity both during and after manufacturing.

Cons

  • The seal on the bottle can be sharp, so be careful when opening it.
  • Some customers have reported that the capsules are unevenly filled.
  • Toniiq Glycine Supplements may not work for everyone, and some customers have reported no improvement in their sleep or nervous system function.

Toniiq Glycine Supplements are new to our daily routine for about six-seven weeks now, and they have proven to help improve our sleep as well as our Nervous System. For this kind of glycine supplements, we understand that each batch goes through testing for quality and purity before it hits the market to satisfy customers with the purest form of glycine supplements they are selling.

We also like the fact that Toniiq Glycine Supplements are made under GMP standards in an NSF certified facility in the USA, which assures us that we are using a formulation that has gone through rigorous testing to ensure it provides the intended benefits.

In conclusion, it is advisable to take Toniiq Glycine Supplements as it is the best supplement that provides glycine for better sleep and nervous system caliber.


Pure Encapsulations Glycine | Amino Acid Supplement

Pure Encapsulations Glycine | Amino Acid Supplement

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The Pure Encapsulations Glycine is absolutely excellent and will able greatly to help those who are in need of liver and kidney support, improved memory, and for better overall nervous system health.

Pros

  • Supports detoxification of certain chemicals
  • May improve memory and mental function
  • Supports healthy kidney and liver function

Cons

  • May not be suitable for those with certain medical conditions
  • May not produce noticeable effects for everyone
  • Some users may experience mild side effects such as nausea or upset stomach

Overall, our team was satisfied with the quality of this supplement and the fact that it contains only the highest quality ingredients sourced from reputable manufacturers. This we like most as it has no soy, dairy, peanuts, tree nuts, shellfish, fish, eggs, wheat, gluten, and sea products; plus no artificial colors, flavors, sweeteners, and preservatives, no unnecessary binders and fillers.

What we discovered was that the supplement was very easier to taken, in form of small capsules easy to swallow. We didn’t observe any changes in our health in the first place, although we understand that this healing product is intended for a long-term beneficial outcome for the consumers’ bodies. We propose this supplement to consumers interested in liver and kidney functioning, and to consumers interested in enhancing their short term memory and cognitive abilities.

In our estimation, Pure Encapsulations Glycine is a reliable, well-formulated glycine supplement for people who aim to boost the human body’s detoxification capabilities.

Buying Guide

When looking for the best glycine supplement, there are a few key factors to consider. Here are some things to keep in mind:

Purity

Before anything, one must make sure that what he/she is taking is a high-quality glycine supplement that has no added unnecessary substances. Opt for the products that have the stamp of approval from a third party to deem them pure.

Dosage

The amounts of consumed glycine may depend on the given product in question and more individually and specifically. Depending on the supplement, it may contain as little as 500mg for the serving size and may contain up to 3000mg set for the serving size. However, for the particular dosage, it is wise to consider your objectives and consult with your healthcare provider.

Form

Its supplements are available in form of capsules, powders, and liquids depending on the manufacturer and the formulating chemist. Capsules are simple on the go because they are simply swallowed, while powders and liquids may require proper dosing.

Price

Cost is another factor that one would give an extra thought while buying supplement products. However, do not look for a product at a cheaper price that is of very poor quality just because you want to save some cash. Choose a product that is good and within the given price range.

Frequently Asked Questions

What are the benefits of taking glycine supplements?

Taking amino acid supplements especially glycine has displayed a number of positive effects. Some of the others are enhancing sleep duration, alleviating inflammation, and sustaining skin and hair health. Secondly, glycine has the role of safeguarding against some diseases; these are the diseases of diabetes and the diseases of the heart.

What are the potential side effects of glycine supplements?

Most sources state that glycine is safe when taken in reasonable dosages, thus meaning that the consumption of glycine supplements should not result in any serious safety concerns. However, since it is natural to enhance the body immune system, some individuals may develop mild side effects like nausea or upset stomach. Anyone thinking of using any supplement should first consult the doctor or any other medical personnel.

How much glycine should I take daily?

Like any other nutritional supplement, the recommended does of glycine varies with many factors such as age, weight, or health state. In studies, doses up to 60 grams per day have been used; therefore, it is suggested that the wrap contains at least 45-50 grams of it per serving. But it is recommended to follow with dosing directions and to consult a healthcare provider prior to starting the intake of a new supplement.

What is the best time of day to take glycine supplements?

As always, controversy exists with references to the peaks and dips of glycine absorption in the body to successfully plot the time for glycine supplementation. While there are individuals who may benefit from consuming glycine products at night for some sleep issues, there are others who may want to incorporate glycine supplements into their morning routine for better general health.

Are there any interactions between glycine supplements and other medications?

Glycine is well tolerated when ingested independently or when combined in products containing different supplements. Nevertheless, it is always advisable to consult a doctor prior to any new supplement bid and particularly if one is on prescription drugs or has any chronic disease.

Can glycine supplements aid in weight loss?

Although glycine has not been investigated in association with weight loss, some existing literature reveals indications that taking glycine supplements can assist in metabolizing food and combating inflammation, more of which may be needed for weight reduction. Yet, there are some gaps in knowledge on the topic, and more research is required to develop a full understanding of how glycine supplements for effective weight loss functions.

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