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Top 5 Best Glycine Supplements for Sleep

Written by Andrew Le, MD

UpdatedOctober 23, 2024

Glycine is one of the amino acids that are present in our body and it has a very important function. A component of proteins which is used in synthesis of collagen which is significant in skin, bone and joint health. It also comes with the property of being a neurotransmitter, which helps in controlling the nervous system and has a relaxing effect on the body.

Glycine is best utilized for its function as a sleep promoting ingredient. It was also observed that glycine supplements can enhance the quality of sleep by decreasing sleep latency and increasing the proportion of stages two, three and REM in the sleep cycle. This is why glycine supplements are widely used by those who suffer from insomnia or any other sleeping disorders.

We acknowledge the fact that a good night sleep is crucial, but this is something that may be a bit difficult to achieve. So, we have made a list of the best glycine supplements for sleep so that you can get the sleep that you deserve.

Top 3 Best Glycine Supplements for Sleep

  1. Nutricost Glycine Powder 1lb
  2. Double Wood Supplements Glycine Supplement
  3. Life Extension Glycine Supplement

To help you decide which glycine supplement you should try, we have gathered and reviewed the best ones available on the market. In the following sections, each product will be reviewed with descriptions of its features, advantages, and, if any, disadvantages. If you have insomnia or would just like to enhance your sleep quality, these supplements are beneficial to your health.


Nutricost Glycine Powder 1lb

Editor's Choice

Nutricost Glycine Powder 1lb

Nutricost Glycine Powder is pure glycine, offering great value in a 1-pound container. It easily mixes with drinks and dishes. We've found it improves sleep quality and daytime alertness, making it an effective, affordable way to enhance your sleep and overall health.

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Speaking of the best glycine supplement for sleep, Nutricost Glycine Powder 1lb is one of the best options. This supplement is free from GMOs, has no gluten, and provides a natural way of getting better sleep and improving well being.

Pros

  • Nutricost Glycine Powder is free from GMOs and gluten
  • It’s cost-effective compared to many other glycine supplements.
  • The powder form allows you to easily mix it into drinks or smoothies.

Cons

  • Some users might find the taste of plain glycine powder a bit unappealing
  • Measuring out the correct dosage can be less precise with powder compared to capsules.

Notably, the Nutricost Glycine Powder has no other ingredients but pure glycine, making it free from extra compounds. The 1-pound container is an advantageous and cost-effective package since it offers a large amount of the supplement. The powder is easily soluble and can be easily mixed with a range of beverages or dishes.

Nutricost Glycine Powder can help improve sleep and also the quality of rest and relaxation. The glycine in this supplement is also used in the sleep-wake cycle regulation, and we have observed the improvement of sleep quality and our wakefulness during the day. Altogether, this supplement can be considered as effective and affordable way to support the process of sleep and health improvement.


Double Wood Supplements Glycine Supplement

Double Wood Supplements Glycine Supplement

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If you are interested in the natural means to enhance the quality of your sleep, then try the Double Wood Supplements Glycine Supplement.

Pros

  • Supports healthy nighttime habits
  • Helps reduce fatigue levels the following day
  • Large bottle size of 300 capsules

Cons

  • May not work for everyone
  • Some users report an unpleasant taste
  • May cause mild stomach discomfort in some users

Taking 3 grams of L Glycine before going to bed has made us develop a good sleeping habit whereby one sleeps early and wakes up early feeling fresh. Among the product highlights, one should mention the 300 capsule bottle size that contains 150 servings of 1,000mg Glycine powder. This means that you will not need to restock for a long period of time, which is both advantageous and economic.

We understand that this product is made in the USA, gluten-free, and is not genetically modified. The capsules are smooth and easy to swallow, while the packaging is neat and the container very robust.

To the best of our knowledge, side effects are negligible but some of the users complained of a foul taste and slight nausea. In other words, Glycine is not suitable for everyone, so before introducing any supplements to your diet, it is advisable to consult your doctor.


Life Extension Glycine Supplement

Life Extension Glycine Supplement

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The Life Extension Glycine Supplement is therefore highly recommended for anyone seeking natural sleep aid as well as whole body health booster.

Pros

  • The supplement contains 1000 mg of glycine, a significantly higher dose than many traditional glycine supplements, providing maximum benefits.
  • Glycine promotes relaxation and sound sleep, making it an effective sleep aid without causing daytime drowsiness.
  • Glycine has additional whole body health benefits, such as supporting healthy glucose and fructose metabolism, preserving muscle mass, and promoting healthy body composition.

Cons

  • The supplement may not work for everyone and may require consistent use to see results.
  • Some users may experience mild side effects such as upset stomach or headaches.
  • The capsules may be difficult to swallow for some individuals.

The higher dose of glycine in each capsules gives the utmost benefits and we like other benefits of glycine especially for the whole body health. Though its efficacy may vary from person to person and it calls for daily use, we think that lavender oil is a natural and safe remedy for sleeplessness.

This supplement is then sourced using the best raw materials to provide you with the purity and quality your body needs. It is Non-GMO and gluten-free and it comes with a Certificate of Analysis on all products manufactured. We believe in Life Extension’s 40 years of expertise in creating scientifically superior and clinically proven formulas using the finest ingredients.


NOW Glycine Supplement

NOW Glycine Supplement

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If you are interested in enhancing the quality of your sleep, we highly recommend the NOW Glycine Supplement.

Pros

  • This supplement promotes restful sleep by functioning as a calming neurotransmitter in the brain.
  • The vegan capsules are pharmaceutical grade and free-form, making it versatile for use in a wide range of functions.
  • The product is GMP Quality Assured, ensuring every aspect of the NOW manufacturing process has been examined.

Cons

  • Exposure to heat or sunlight may lead to melting/damage of the product, so customers are expected to be available during the product delivery.
  • During the summer months, the product may arrive warm due to shipping, but Amazon stores and ships products in accordance with manufacturers' recommendations.
  • Some customers have reported that the capsules are large and difficult to swallow.

The ingredient in the NOW Glycine Supplement that works to regulate neurotransmitters has aided us in getting to sleep more easily and for longer. We especially like that it is vegan and is in the form of capsules, which can be useful at any event. Also, the GMP Quality Assured certification makes us comfortable knowing that everything in the manufacturing process has been checked.

The only probable drawback of this product is that when it comes into contact with heat or sunlight, the product can melt/damage, so customers should be available at the time of product delivery. Furthermore, the product comes warm during the summer months because of shipping, however Amazon , stores and ships products based on manufacturers guidelines. Some customers have also pointed out that the capsules are rather large to swallow, which can be an issue for certain consumers.


Pure Encapsulations Glycine

Pure Encapsulations Glycine

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For those who are interested in boosting liver and kidney performance, nervous system health, and detoxing, we recommend Pure Encapsulations Glycine without reservation.

Pros

  • Supports detoxification and liver and kidney function
  • May support memory and mental function
  • Made with premium ingredients and free from unnecessary binders, fillers & preservatives

Cons

  • May not work for everyone
  • May take time to see results
  • Large capsules may be difficult to swallow for some

We acknowledge that it is made from high-quality ingredients that are procured from reputable companies, and it has no added binders, fillers or preservatives. Also, it is easy to consume since it comes in capsule form, with one container containing 180 capsules.

We also understand that Glycine from Pure Encapsulations supports the detox process, the liver and the kidneys and the nervous system as well. Although it may still take time to reap the fruits of the exercise, we think it is worth a shot given the benefits that come with it.

Buying Guide

When searching for the best glycine supplement for sleep, there are some factors that must be put into consideration in order to get the best supplement. In this section, we will describe the key points that must be taken into consideration when selecting a glycine supplement.

Purity and Quality

The quality and purity of the supplement are crucial. Identify a product with no added substances such as fillers, artificial colors, flavors, and preservatives. The best glycine supplement must come from pure and pharmaceutical grade glycine.

Dosage

Another factor is the dosage of glycine. The dosage of glycine supplements differs based on the intended use as follows: For sleep, it is recommended that one takes between 3-5 grams of the substance before they retire to bed. However, it is always wise to seek advice from a doctor before taking any new supplement.

Form

Glycine is available in capsules, powders, and liquids. Baclofen capsules are easy to administer while powders and liquids can be dissolved in water or other liquids. Select the form that is most appropriate to your timetable and does not interfere with your daily routine.

Price

Price remains an essential factor when it comes to the buying of supplements. But it should be noted that cheap does not always mean the best. Therefore, look for a product in which quality is best balanced with price.

Frequently Asked Questions

What are the benefits of taking glycine supplements for sleep?

Glycine – an amino acid – has been also found to have a positive impact on calming down brain and improving the quality of sleep. It has also been useful in cutting down the time that a person takes to sleep and also the number of times one wakes up throughout the night.

How much glycine should I take to improve my sleep?

The suggested dosage of glycine to enhance sleep quality is between 3 and 5 grams daily. The starting dose is usually lower and as one develops tolerance the dose is then gradually raised. Before you embark on taking any new supplement, it is advisable to discuss with your doctor.

Can glycine and melatonin be taken together to improve sleep?

Yes, glycine and melatonin can be taken together to enhance sleep quality. Indeed, there is evidence that glycine and melatonin together are even more effective than when each of the supplements is taken separately.

What are the potential side effects of taking glycine supplements?

Supplementation with glycine is also regarded as safe for many consumers as long as recommended doses are not exceeded. However, some users may experience undesirable effects like nausea, stomach discomfort or dizziness. If you notice any side effects while using glycine, you should discontinue its use and consult with your doctor.

Is it safe to take glycine supplements every night?

Glycine supplements are not toxic and can be taken every night but one should consult their doctor before using any new supplement. It is also required to stick to the recommended dosage and avoid taking more than what is recommended.

What is the difference between glycine and glycinate supplements?

Glycine and glycinate are related but distinct molecules; glycinate supplements are generally more bioavailable than glycine supplements. This suggests that glycinate supplements may be even better at enhancing sleep quality than glycine supplements. However, further studies are required to validate these findings.

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