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What Is Anaphylaxis?
Anaphylaxis is a life-threatening condition most commonly caused by an allergic reaction. In anaphylaxis, two types of immune cells — mast cells and basophils — are suddenly activated and release numerous inflammatory substances that cause blood vessels to dilate and become leaky, which can lead to low blood pressure, swelling, and damage to organs [1,2].
Symptoms of anaphylaxis include itching, redness, and warmth in the form of hives, as well as itching or swelling of the lips, tongue, mouth, or around the eyes, as well as difficulty breathing and nasal congestion. Several other symptoms are also likely.
Anaphylaxis is a medical emergency. Treatment options will likely involve an epinephrine injection (same contents as in an EpiPen), followed by oxygen and IV fluids, other medications, and an action plan for possible future incidents.
Call 911 immediately for an ambulance. If you have been prescribed an epinephrine pen, use it. Don't do this if you have never been prescribed one!
Symptoms of anaphylaxis usually develop within seconds to minutes after exposure to a trigger, although in some cases symptoms develop hours later. Symptoms may be mild and resolve on their own, but in many cases, the symptoms can worsen rapidly and even lead to death if not treated as an emergency. In some cases, the symptoms may recur within 12 hours of the initial episode, known as a biphasic reaction.
The main symptoms experienced by most people with anaphylaxis include:
- Itching, redness, warmth, and/or hives: Hives, which are raised itchy red bumps on the skin, usually occur all over the body shortly after exposure to the trigger.
- Itching, tingling, and/or swelling of the lips, tongue, or mouth: In severe cases, the swelling may make it difficult to swallow or breathe.
- Itching or swelling around the eyes and/or red eyes: The eyes may also tear from the irritation.
- Difficulty breathing or noisy breathing: There may be a sensation of choking or the throat closing. The noisy breathing can be heard either when breathing in or breathing out.
- Nasal congestion or discharge: This may occur rapidly in some people with anaphylaxis.
Other symptoms that may occur in some people with anaphylaxis include:
- Abdominal pain, cramps, nausea, vomiting, and/or diarrhea: This occurs in about half of people with anaphylaxis. These symptoms are caused by swelling of the gastrointestinal tract.
- Dizziness, lightheadedness, confusion, or passing out: During anaphylaxis, the blood vessels throughout the body dilate, causing a fall in blood pressure and the prevention of enough blood from reaching the brain, which leads to these symptoms.
- Chest pain or feeling the heart racing: These symptoms may occur because, during anaphylaxis, the heart beats faster to try to compensate for the low blood pressure.
- Anxiety and/or a sense of impending doom
Most cases of anaphylaxis are caused by a reaction to an allergen, such as foods, insect stings, and bites, or certain medications. Some cases of anaphylaxis are caused by a non-allergic type reaction, in which mast cells and basophils are directly activated. Other common causes of anaphylaxis can also be related to exposures listed below [2,3].
Foods are the most common cause of anaphylaxis in children, teenagers, and young adults. Common foods that can trigger anaphylaxis include:
- Tree nuts
- Crustacean shellfish
Insect stings and bites
Insect stings and bites are a common cause of anaphylaxis, especially among older adults. Common insects that can trigger anaphylaxis include:
- Fire ants
Medications are another common cause of anaphylaxis, especially among older adults. Common medications that can trigger anaphylaxis include:
- Some over-the-counter pain medications
- Intravenous contrast used in some imaging studies
In addition, some medications can exacerbate anaphylactic reactions or prevent the body from responding to anaphylaxis. These include:
- Certain medications used for heart disease and high blood pressure
Being exposed to the following can also cause anaphylaxis or an allergic reaction in some people:
- Latex: Many medical centers now use latex-free gloves to reduce the risk of triggering an allergic reaction.
- Exercise: This is a special type of anaphylaxis known as exercise-induced anaphylaxis.
- Exposure to cold or heat
Anaphylaxis Symptom Checker
Take a quiz to find out if you have Anaphylaxis
Treatment Options and Prevention for Anaphylaxis
The most important initial treatment for anaphylaxis involves administering epinephrine. Other specific components of treatment include oxygen and IV fluids, other medications, as well as education to better handle any future incidents [4,5].
Epinephrine is injected into a vein (IV) or a muscle by a clinician to restore blood pressure and heart function during anaphylaxis.
- Details: The best way to give epinephrine is to inject it into a muscle, usually the side of the thigh.
- Types: People who have had episodes of anaphylaxis may be prescribed an epinephrine autoinjector, such as EpiPen, Adrenaclick, or Auvi-Q, and they will be instructed how to use it. In some cases, additional epinephrine may be given intravenously after it has been injected into the muscle.
Oxygen and IV fluids
In addition to an epinephrine injection, you may also be given:
- Supplemental oxygen: This may be given through a mask to ensure there is adequate oxygen in the blood. If swelling in the mouth or throat is causing difficulty breathing, intubation may be necessary.
- Intravenous fluids: IV fluids are given to maintain blood pressure. Because anaphylaxis causes the blood vessels throughout the body to dilate, a large amount of IV fluid may be needed to maintain a normal blood pressure.
To help relieve symptoms after epinephrine has been given, the following may also be used.
- Albuterol: This may be used to help with wheezing and difficulty breathing.
- Diphenhydramine (Benadryl) or other antihistamines: Certain medications may be given to relieve itching.
- Steroids: Such as methylprednisolone, which may be given to help reduce inflammation.
Education and future action plan
Education and the creation of an anaphylaxis emergency action plan is important after the acute episode of anaphylaxis has been treated to avoid and manage future anaphylaxis episodes. This may involve:
- Creating a list of possible causes to avoid
- A prescription of and instructions for how to use epinephrine autoinjectors
- What to do if symptoms of anaphylaxis recur
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When to Seek Further Consultation for Anaphylaxis
If you experience any symptoms of anaphylaxis, such as hives, swelling, or trouble breathing, you should go to the emergency room or call an ambulance immediately.
If you believe you are having another episode and you have an autoinjector
You should use your autoinjector if you feel confident doing so and you feel symptoms of another episode of anaphylaxis coming on. You should go to the emergency room immediately after.
Questions Your Doctor May Ask to Determine Anaphylaxis
To diagnose this condition, your doctor would likely ask about the following symptoms and risk factors.
- Are you sick enough to consider going to the emergency room right now?
- Have you been feeling more tired than usual, lethargic or fatigued despite sleeping a normal amount?
- Any fever today or during the last week?
- Have you experienced any nausea?
- Have you lost your appetite recently?
If you've answered yes to one or more of these questions
Anaphylaxis Symptom Checker
Take a quiz to find out if you have Anaphylaxis
- Anaphylaxis symptoms and causes. Mayo Clinic. Published January 5, 2018. Mayo Clinic Link.
- Anaphylaxis. American College of Allergy, Asthma, & Immunology. Updated January 29, 2018. ACAAI Link
- Anaphylaxis: A severe allergic reaction. Asthma and Allergy Foundation of America. Updated February 2017. AAFA Link
- Tupper J, Visser S. Anaphylaxis: A review and update. Canadian Family Physician. 2010;56(10):1009-1011. NCBI Link
- Anaphylaxis. U.S. National Library of Medicine: MedlinePlus. Updated December 6, 2018. MedlinePlus Link
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