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Is It ADHD or a Hidden Mood Disorder? 5 Overlooked Conditions That Mimic Your Symptoms

ADHD vs mood disorder
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Written by Andrew Le, MD.
Medically reviewed by
Last updated July 15, 2025

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It’s not always easy to tell what’s really going on when someone struggles with focus, low energy, or strong emotions. You might wonder, is it ADHD, or could it be something else? These symptoms can look very similar across different conditions, especially in teens and young adults.

During adolescence, the brain is still developing. The prefrontal cortex, which controls focus and decision-making, matures slower than areas that process emotions and rewards. This imbalance can lead to impulsive behavior, mood swings, and trouble with attention—even in those without ADHD. According to research , these patterns are part of typical brain development, not always a disorder.

Misdiagnosis happens when symptoms are seen in isolation. That’s why it’s important to look deeper, especially when ADHD treatments don’t seem to help. Some emotional or hormonal conditions can mimic ADHD—but need a different kind of support.

Depression

Depression doesn’t always look the way people expect. It can show up as tiredness, irritability, or lack of focus—symptoms that closely resemble ADHD. You might feel restless, forgetful, or unable to finish tasks. But instead of a focus problem, it could be that your mind is weighed down by something deeper.

Some common ways depression can mimic ADHD include:

  • Trouble concentrating or finishing tasks
  • Feeling low-energy or constantly tired
  • Irritability, especially in teens
  • Restlessness or appearing distracted
  • Loss of interest in things you used to enjoy

Some types of depression are more subtle. For example, dysthymia is a long-lasting form of low mood that can be mistaken for chronic inattention or laziness. In teens, especially boys, depression may appear as anger or withdrawal instead of sadness.

According to experts, the brain sometimes uses involuntary coping mechanisms to hide painful feelings, which can mask depression under behaviors that look like ADHD. Studies also show that genes tied to sex hormones, like estrogen receptor (ESR1) and COMT—may increase a person’s risk for depression by influencing how their brain manages stress and emotion.

Anxiety Disorders

Anxiety can look a lot like ADHD—but it comes from a different place. Instead of a brain that’s wired for distraction, it may be a mind stuck in overdrive. Worry and fear can make it hard to sit still, stay focused, or even follow through on simple tasks.

People with anxiety may experience:

  • Racing thoughts or overthinking
  • Avoiding tasks that feel overwhelming
  • Restlessness or fidgeting
  • Trouble sleeping or relaxing
  • Difficulty staying focused because of constant worry

Unlike ADHD, anxiety often brings physical symptoms too, like a tight chest, sweaty hands, or an upset stomach. These can happen before a test, a meeting, or even a simple conversation.

Experts explain that the brain uses automatic defense mechanisms—such as avoidance or suppression—to protect itself from distress. While this can help in the short term, it also hides the real issue, making it harder to tell anxiety apart from other conditions.

When anxiety starts early in life, it may affect how the brain grows and functions. Research found that emotional parts of the brain mature faster than areas responsible for control. This may cause anxious children and teens to appear impulsive or distracted—just like ADHD.

PTSD and Trauma

Sometimes, what looks like ADHD is actually the brain’s response to trauma. After a painful or frightening event, the mind stays on high alert. This can lead to behaviors that seem impulsive, distracted, or hyperactive—but are actually signs of Post-Traumatic Stress Disorder (PTSD).

People dealing with trauma may show:

  • Jumpiness or being easily startled
  • Trouble concentrating or remembering things
  • Angry outbursts or emotional numbness
  • Avoidance of people, places, or situations
  • Constant feelings of danger, even when safe

These symptoms can be misread as ADHD, especially in children or teens who may not be able to explain their experiences. According to experts, the brain may use unconscious defenses like dissociation or denial to cope with trauma. These defenses can shape behavior in ways that confuse even trained professionals.

Studies on adolescent brain development also reveal that after trauma, the amygdala (a brain area tied to fear) becomes more reactive, while areas for judgment and control may still be maturing. This imbalance often leads to emotional outbursts, trouble focusing, or risk-taking—symptoms that overlap with ADHD.

Hormonal Imbalances

Hormones do more than control puberty or periods—they also shape how we feel, think, and react. When these chemicals become unbalanced, they can affect focus, mood, and energy in ways that closely mimic ADHD.

Some signs linked to hormone-related problems include:

  • Sudden mood swings or emotional outbursts
  • Brain fog or trouble concentrating
  • Feeling tired but wired
  • Trouble sleeping or feeling restless
  • Low motivation despite effort

Hormones like estrogen, testosterone, and progesterone impact areas of the brain that control attention, emotion, and behavior. Changes in these levels—during puberty, a menstrual cycle, or menopause—can lead to symptoms that look just like ADHD.

Research by Westberg and Eriksson (2008) shows that genes related to these hormones—such as ESR1, AR, and COMT, may influence how sensitive people are to emotional stress or focus problems. These effects can be different in males and females, making diagnosis even more tricky.

According to studies, even slight shifts in hormone levels can increase the risk for depression, anxiety, or irritability, all of which are sometimes misdiagnosed as ADHD.

Substance Use or Emotional Coping

Not all signs of ADHD come from a disorder. Sometimes, they’re a result of how people try to cope with pain, stress, or emotional overload. Teens and young adults may turn to risky behavior, substance use, or distraction as a way to feel better. These actions can look a lot like impulsivity or poor focus—but they often come from emotional survival.

Behaviors that may be mistaken for ADHD include:

  • Sudden changes in energy or behavior
  • Risk-taking or thrill-seeking
  • Using alcohol, nicotine, or other substances to “calm down
  • Acting out in school or at home
  • Zoning out or avoiding responsibilities

Research explains that the adolescent brain has a reward system that matures earlier than the areas responsible for judgment and control. This means young people are more likely to chase excitement or avoid discomfort, even if it leads to negative consequences.

When these coping behaviors are misunderstood, the person may be labeled as “hyper” or “unmotivated.” But according to experts, they may actually be using involuntary defense mechanisms—unconscious actions that help protect against emotional stress.

Wrap Up

Knowing the difference between ADHD and other look-alike conditions is key to getting the right help. What seems like poor focus or hyperactivity might be depression, anxiety, trauma, hormones, or even emotional coping. These issues can all affect how the brain works, especially during the teen years.

If ADHD treatment doesn’t seem to work, it might be time to look deeper. Are the symptoms really about focus, or is something else hiding underneath? A full, thoughtful evaluation can lead to better support, better treatment, and a better path forward. You don’t have to figure it out alone.

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The stories shared below are not written by Buoy employees. Buoy does not endorse any of the information in these stories. Whenever you have questions or concerns about a medical condition, you should always contact your doctor or a healthcare provider.
Jeff brings to Buoy over 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medi...
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