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Can you safely take Cialis with omega-3 fatty acids?

cialis with omega 3 fatty acids
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Written by Andrew Le, MD.
Medically reviewed by
Last updated November 20, 2025

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Many people take Cialis to improve blood flow and sexual function. Others use omega-3 fatty acids to support their heart and reduce inflammation.

But what if you use both? Could this combination cause issues, or is it safe for most people?

Both can influence circulation. Cialis lowers blood pressure by relaxing blood vessels, while omega-3s may thin your blood and change how it clots. When used together, they can push your body a bit further than expected. Dizziness, bruising, or bleeding might appear without much warning.

What should you know before combining Cialis and omega-3s?

Taking Cialis and omega-3s together usually isn’t harmful. But both affect the way blood moves through your body. Cialis helps your blood vessels open up, while omega-3s can make your blood slightly thinner.

That means they might both lower blood pressure. When this happens at the same time, you could feel dizzy or lightheaded. The effect can be mild, but in some cases, it becomes more noticeable, especially when you stand up suddenly or move too fast.

Omega-3s can also increase the chance of bruising or bleeding, particularly if you take them with other blood-thinning drugs or after an injury. If you take heart or blood pressure medication, you should talk to your doctor before mixing these treatments. And before surgery, your doctor needs to know if you’re using both because they may slightly raise bleeding risk.

What exactly is Cialis, and how does it work?

Cialis, also known by its generic name tadalafil, increases blood flow to certain parts of the body. It belongs to a group of drugs called phosphodiesterase type 5 inhibitors, or PDE5 inhibitors. These drugs help the smooth muscles inside your blood vessel walls relax, especially in the penis. When that happens, blood can enter more easily, helping you get and keep an erection during sexual activity.

How does this happen?

Tadalafil blocks an enzyme called PDE5. Normally, PDE5 breaks down a substance in your body called cyclic guanosine monophosphate (cGMP). When Cialis blocks PDE5, your cGMP levels stay higher for longer. Because of that, your blood vessels stay relaxed longer, allowing stronger blood flow and better erections when you are sexually aroused.

Does Cialis have other uses?

Yes. Doctors also prescribe tadalafil to treat benign prostatic hyperplasia, or BPH. That means it helps relax muscles in the bladder and prostate, making it easier to urinate.

Still, Cialis does not create an erection automatically. Sexual stimulation is required for it to work. One reason people prefer Cialis is that its effects last up to 36 hours, which is much longer than other similar medicines such as sildenafil.

How do omega-3 fatty acids work in the body?

Omega-3 fatty acids affect how your cells and body systems function. They are essential fats, which means your body cannot make them by itself. You must get them from food or supplements.

There are three main types of omega-3 fatty acids:

  1. EPA (eicosapentaenoic acid)
  2. DHA (docosahexaenoic acid)
  3. ALA (alpha-linolenic acid)

EPA and DHA are found mainly in fish oils. ALA comes from plant oils such as flaxseed and walnuts.

How do they work inside your body?

Omega-3s act as building blocks of your cell membranes. They help keep cells flexible and healthy. But they also do more. They help regulate inflammation, blood clotting, and heart rhythm.

Omega-3 supplements are often used to lower triglycerides, a type of fat that increases heart disease risk. When taken consistently with a balanced diet, omega-3s can help reduce triglycerides and protect your arteries.

They can also thin the blood slightly, which lowers the chance of forming clots. This helps your heart but can cause easy bruising or extra bleeding, especially if you already take blood-thinning medicine.

Some studies also show omega-3s might have links to mental health. However, research results have been mixed. One study noted an increased bleeding risk when omega-3s were taken with anti-clotting drugs. Another suggested possible interactions with chemotherapy agents like cisplatin.

What happens if you take Cialis and omega-3s together?

According to medical databases, there is no direct drug-to-drug interaction between Cialis (tadalafil) and omega-3 fatty acids. That means they do not chemically interfere with each other inside your body. Taking both does not change how each one works.

However, that does not mean there is zero risk. It simply means researchers have not found a confirmed harmful reaction in studies so far. There are still indirect effects to consider because both influence your blood pressure and blood flow.

Does that mean they’re safe together?

Generally, yes. This combination is not listed for any major, moderate, or minor interaction in medical resources. This supports the idea that most people can take Cialis and omega-3s safely, as long as a doctor is supervising.

Still, your individual health matters. Always ask your doctor before taking both, especially if you already take medicines for blood pressure, heart disease, or clotting problems.

What are the main safety considerations?

Here are some of the risks you should know about:

1. Bleeding risk

Cialis and omega-3s both influence circulation. Omega-3s may thin the blood slightly by reducing platelet activity. This helps prevent clots but raises the risk of bleeding. Older adults who took omega-3s with blood thinners showed higher bleeding risks in one study.

Cialis itself does not thin the blood. But if you already take anticoagulant drugs or have bleeding issues, the combination may increase your chance of bruising or internal bleeding.

2. Low blood pressure

Tadalafil acts as a vasodilator, meaning it opens blood vessels and lowers blood pressure. Omega-3s can also lower blood pressure over time. When you combine them, your blood pressure might drop more than expected. This can make you feel dizzy, faint, or lightheaded, especially when you stand up too quickly.

If you already take medication for high blood pressure, your doctor should monitor this combination closely.

3. Surgery and wound healing

Before surgery, doctors often review all medicines and supplements. Omega-3s may increase surgical bleeding because of their blood-thinning effect. Since Cialis also affects circulation, your doctor might recommend pausing one or both before surgery. Always inform your surgeon about every product you take.

3. Heart health and other conditions

If you have a heart condition, your doctor should review this combination carefully. Cialis can increase heart workload during sexual activity, while omega-3s generally support heart rhythm and lower triglycerides. For people already taking heart medicines, it’s best to double-check with a healthcare professional before mixing these.

Final answer

  • There is no direct interaction between Cialis and omega-3 fatty acids.
  • Both can lower blood pressure, which might cause dizziness or fainting.
  • Omega-3s can thin the blood, raising the chance of bruising or bleeding.
  • Inform your doctor before surgery or if you take blood pressure or heart medicines.
  • The combination is usually safe under supervision, but it should be watched closely in people with heart, circulation, or bleeding problems.
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Jeff brings to Buoy over 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medi...
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