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Best prescription Rx for orchitis

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Written by Andrew Le, MD.
Last updated July 23, 2024

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Introduction

Orchitis is a condition that causes inflammation of one or both testicles. While it can affect males of any age, it most commonly happens in those 15-30 and over 60 years old. Orchitis can be quite painful and concerning, but fortunately, effective treatments are available. In this comprehensive guide, we'll look at what orchitis is, its causes, symptoms, diagnosis, treatment, and prevention strategies. By understanding this condition better, you'll be well-equipped to recognize potential signs and know when to seek medical care.

What Is Orchitis?

Orchitis refers to inflammation of one or both of the testicles, the oval-shaped glands in the scrotum that make sperm and male hormones. Each testicle is encased in a fibrous capsule and divided into several hundred smaller compartments called lobules. Sperm is made in tightly coiled tubes called seminiferous tubules within these lobules. Inflammation can affect any of these structures, leading to an enlarged, painful testicle.

Orchitis occurs in about 14-35% of postpubertal males who contract mumps. It's most frequently seen in those aged 15-30 and over 60. Orchitis often develops with epididymitis, inflammation of the epididymis, the coiled tube at the back of each testicle that collects and carries sperm. When both structures are involved, the condition is referred to as epididymo-orchitis.

Causes of Orchitis

Orchitis can be caused by either a bacterial or viral infection. The most common bacterial causes are sexually transmitted infections (STIs) like gonorrhea and chlamydia, particularly in men under 35. Orchitis can also develop because of a bacterial infection spreading from the urinary tract or prostate. Potential pathogens include Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

In males over 35, urinary tract infections (UTIs) and prostate infections become more frequent causes of bacterial orchitis. Risk factors include an enlarged prostate, urinary catheter use, and structural abnormalities of the urinary tract that impede urine flow. Treating these conditions can help prevent the infection from spreading to the testicles.

Viral orchitis, on the other hand, is most often caused by the mumps virus. Orchitis develops in about 30% of males who contract mumps after puberty. It typically appears 4-10 days after mumps symptoms like fever and swollen salivary glands start. Other viral causes of orchitis include coxsackievirus, varicella-zoster virus (the cause of chickenpox and shingles), and HIV.

In rare cases, orchitis can be triggered by a non-infectious cause, such as testicular trauma, autoimmune conditions like Behçet's disease and polyarteritis nodosa, or the use of certain medications like amiodarone.

Symptoms and Diagnosis of Orchitis

The main symptoms of orchitis include:

  • Swelling, redness, and tenderness of one or both testicles
  • The affected testicle may feel warm to the touch
  • Swollen two to three times its normal size
  • Dull ache or sharp pain in the scrotum, lower abdomen, and groin
  • Pain may get worse during bowel movements, urination, or ejaculation

Accompanying symptoms can offer clues to the underlying cause. Fever, chills, nausea, vomiting, and a general sense of unwellness point to an infection. A burning sensation during urination or penile discharge suggests a sexually transmitted or urinary tract infection. If mumps is the cause, orchitis typically appears a week after facial swelling begins.

To diagnose orchitis, your healthcare provider will start by asking about your symptoms, sexual history, and medical history. They'll perform a physical exam to check for swelling, tenderness, warmth, and redness. Since the symptoms of orchitis overlap with those of other serious testicular conditions like testicular torsion (a twisted testicle), testicular cancer, and inguinal hernia, your provider may recommend additional testing.

Imaging tests like ultrasound or MRI can show signs of inflammation, rule out torsion (which needs emergency surgery), and check for masses that could be cancerous. Blood and urine tests can detect markers of infection and inflammation. If a sexually transmitted infection is suspected, you may need to provide a urine sample or urethral swab for STI testing.

If you're sexually active, regular STI testing is important for protecting your health and that of your partners. Many STIs, including chlamydia and gonorrhea, can be asymptomatic, meaning you could have an infection without realizing it. Fortunately, you can now access STI testing from the privacy of home thanks to at-home STI testing services. These services send you a discreet testing kit, which you then mail back to a lab for analysis. If results are positive, you'll have the opportunity to speak with a healthcare provider and get prompt treatment. Look for a service that uses accredited labs, offers comprehensive testing for a wide range of STIs, and provides clear instructions and support throughout the process.

Treating Orchitis

Treatment for orchitis depends on the underlying cause. Some of these causes and their treatments include:

  • Bacterial orchitis: Bacterial orchitis needs prompt antibiotic therapy to clear the infection and prevent complications. If sexually transmitted bacteria like Neisseria gonorrhoeae or Chlamydia trachomatis are the cause, the CDC recommends a single intramuscular dose of ceftriaxone plus a 10-day course of oral doxycycline.

For bacterial orchitis not related to STIs, fluoroquinolone antibiotics like ciprofloxacin or levofloxacin are often used. Treatment typically lasts 10-14 days. If an abscess (a pocket of pus) develops, surgical drainage may be needed.

  • Viral orchitis: Orchitis caused by a virus, such as that caused by mumps, doesn't respond to antibiotics. Treatment focuses on relieving symptoms while the body fights off the virus. Over-the-counter pain relievers like acetaminophen or ibuprofen can help control fever and discomfort. Applying cold packs and wearing an athletic supporter can ease pain and swelling. Rest is also important.

In addition to medication, your healthcare provider may recommend several self-care measures. Some of these include:

Avoid sexual activity until the infection clears completely to prevent spreading the infection to others. If your orchitis was caused by an STI, your partner(s) should also be tested and treated. Don’t do any heavy lifting and strenuous exercise until pain and swelling subside.

While most cases of orchitis resolve without complications, there's a risk of serious consequences if left untreated. Chronic epididymitis (long-term inflammation of the epididymis) can cause persistent pain and swelling. Rarely, untreated bacterial orchitis can progress to sepsis, a life-threatening systemic infection. Mumps orchitis can occasionally lead to testicular atrophy (shrinkage) and lowered fertility, especially if both testicles are affected.

Preventing Orchitis

Preventing orchitis starts with reducing your risk of infections that can lead to this condition. Some ways to prevent orchitis include:

  • Get vaccinated: The mumps vaccine, typically given as part of the MMR (measles, mumps, rubella) vaccine, offers excellent protection against mumps-related orchitis. The CDC recommends that children receive two doses of MMR vaccine, the first at 12-15 months and the second at 4-6 years.
  • Practice safe sex: Practicing safer sex can help prevent STI-related orchitis. Use condoms consistently and correctly during sexual activity. Limit your number of sexual partners and ask about STI testing before starting a new sexual relationship. If you do test positive for an STI, promptly inform your partners so they can seek testing and treatment.
  • Keep good hygiene: Maintaining good personal hygiene, including washing your genitals daily and after sexual activity, can help reduce bacterial buildup that can lead to UTIs and prostate infections. Urinating shortly after sex can also help flush out bacteria. If you have symptoms of a UTI, such as burning during urination, increased urinary frequency or urgency, or cloudy urine, see your healthcare provider for treatment.

If you have an enlarged prostate or other condition that affects urinary flow, work with your healthcare provider to manage these issues, as they can increase your orchitis risk if left untreated. Drink plenty of water, avoid holding your urine for prolonged periods, and consider prostate medications or procedures if recommended by your provider.

Familiarize yourself with the signs and symptoms of orchitis and seek medical care promptly if you experience testicular pain or swelling. Many testicular conditions, from orchitis to testicular torsion and cancer, are most easily treated when caught early. Perform monthly testicular self-exams and notify your healthcare provider of any lumps, bumps, or other abnormalities.

Conclusion

Orchitis is a potentially painful and distressing condition, but understanding its causes, symptoms, and treatment options can help you get the care you need to feel better.

By taking steps to prevent bacterial and viral infections, practicing safer sex, maintaining good hygiene, and seeking prompt medical care for testicular symptoms, you can reduce your orchitis risk and protect your reproductive health.

Your healthcare provider is your partner in managing orchitis and any other health concerns you may face. Don't hesitate to discuss your symptoms and treatment options with them. With proper care and attention, orchitis can be effectively treated, allowing you to get back to living your healthiest life.

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The stories shared below are not written by Buoy employees. Buoy does not endorse any of the information in these stories. Whenever you have questions or concerns about a medical condition, you should always contact your doctor or a healthcare provider.
Dr. Le obtained his MD from Harvard Medical School and his BA from Harvard College. Before Buoy, his research focused on glioblastoma, a deadly form of brain cancer. Outside of work, Dr. Le enjoys cooking and struggling to run up-and-down the floor in an adult basketball league.

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