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Guillain-Barre Syndrome

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Last updated May 22, 2023

Guillain-barre syndrome quiz

Take a quiz to find out if you have guillain-barre syndrome.

Guillain-Barre syndrome is a condition in which the body's immune system damages parts of neurons. Symptoms include progressive weakness, numbness or tingling, decreased reflexes, body aches, double vision, loss of balance, abnormal heart rhythms or blood pressure, and difficulty breathing.

What is Guillain-Barre syndrome?

Guillain-Barre syndrome is a condition in which the body's immune system damages parts of neurons. Guillain-Barre syndrome usually occurs after an infection or other triggering event. It is believed that the event leads to an abnormal immune response in which the body produces antibodies, specific immune particles that attack neurons or the material lining the neurons.

Symptoms include progressive weakness, numbness or tingling, decreased or loss of reflexes, pain in the arms, leg, or back, double vision, loss of balance, abnormal heart rhythms or blood pressure levels, and difficulty breathing.

Treatment primarily involves intravenous immunoglobulin therapy or plasma exchange therapy, along with monitoring in a hospital or intensive care unit and supportive care for pain and abnormal vital signs.

You should seek immediate medical care at an ER. Nerve damage can potentially impair your ability to control your heart and lungs. You may need to be admitted to the hospital.

Guillain-Barre syndrome symptoms

There are a few different variants of Guillain-Barre syndrome, which differ in their disease processes and symptoms. These include acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor and sensory axonal neuropathy (AMSAN), and Miller Fisher Syndrome. The diagnosis for this condition is made by clinical evaluation, although electrophysiologic studies and cerebrospinal fluid testing can support the diagnosis.

Main symptoms

Symptoms that can generally be seen in Guillain-Barre syndrome include:

  • Muscle weakness: This weakness usually starts in the legs and classically progresses up the body, but in some cases can start in the arms or face. The weakness is usually symmetric on both sides of the body. Overall, muscle weakness and other symptoms of Guillain-Barre syndrome usually worsen over the course of days to weeks. Seventy-three percent of people will reach maximum symptoms by one week and 98 percent will reach maximum symptoms by four weeks; symptoms will then plateau and begin to improve in a few days, although may persist for weeks.
  • Numbness or tingling: This usually affects the hands or feet.
  • Decreased or loss of reflexes in the arms or legs: This may be noticed when your physician examines you with a reflex hammer.

Other symptoms

Other symptoms that are also likely with this condition include the following.

  • Pain in the arms, legs, or back: About one-half of patients with Guillain-Barre syndrome will develop pain in the arms, legs, or back. The pain is usually described as a deep, aching pain and may be accompanied by muscle cramps.
  • Double vision and/or loss of balance: This is classically seen in the Miller Fisher Syndrome variant of Guillain-Barre syndrome.
  • Abnormal heart rhythms or blood pressure levels: This can occur if the inflammation affects the autonomic nervous system, the part of the nervous system that controls heart rate and blood pressure. This may cause you to feel chest discomfort, lightheadedness, or loss of consciousness.
  • Difficulty breathing: This occurs due to weakness in the muscles that are important for breathing. In some cases, the respiratory muscle weakness may be severe enough that you need to be intubated. This occurs in approximately 30 percent of cases.

Guillain-Barre syndrome causes

Guillain-Barre syndrome usually occurs after an infection or other triggering event. It is believed that the event triggers an abnormal immune response in which the body produces antibodies, specific immune particles that attack neurons or the material lining the neurons. The risk of developing Guillain-Barre syndrome increases with increasing age and is slightly more common in men than in women. Specific causes of Guillain-Barre syndrome include infections and vaccination.


Approximately two-thirds of cases of Guillain-Barre syndrome occur after an infection, and infections are thought to potentially trigger Guillain-Barre syndrome through an immune-mediated process. The preceding infection is usually a respiratory or gastrointestinal infection, and symptoms of Guillain-Barre syndrome usually develop within one month.

  • Campylobacter jejuni: This is the most common infection associated with Guillain-Barre syndrome, which a bacterium that causes diarrhea and can be acquired from eating raw meat or contaminated dairy or produce. It is seen in 25 to 50 percent of adult patients.
  • Other infections: Other associated infections include HIV, influenza, hepatitis viruses, and Zika virus, among others.


Studies have shown that certain vaccinations, including certain types of influenza vaccines, may be associated with a very slight increased risk of developing Guillain-Barre syndrome, with a risk of approximately one to two cases per 1 million people immunized. Therefore, this risk must be weighed against the much greater risks of developing the disease that the vaccine protects against. A surveillance system administered by the Centers for Disease Control (CDC) and the U.S. Food and Drug Administration (FDA) concluded that the risk of developing vaccine-associated Guillain-Barre syndrome is less than the risk of severe influenza.

Treatment options and prevention

Although Guillain-Barre syndrome will eventually resolve on its own, it often causes serious symptoms such as paralysis and difficulty breathing that need to be treated with supportive therapies in an intensive care unit. In addition, certain treatments have been shown to shorten the duration of symptoms in Guillain-Barre syndrome and are generally recommended to improve outcomes. Therefore, most people diagnosed with Guillain-Barre syndrome are admitted to the hospital for close monitoring and supportive treatment. Specific treatment for Guillain-Barre syndrome includes the following.

Intravenous immunoglobin (IVIG) therapy

This therapy involves administering a collection of antibodies collected from healthy donors. This is thought to help treat Guillain-Barre syndrome by reducing inflammation and blocking the effect of abnormal antibodies.

Plasma exchange therapy

A component of your blood is removed and replaced with donor blood components. This therapy is thought to help by removing antibodies that may be attacking the nerves. This therapy usually involves multiple treatments over eight to 10 days. Studies have shown that plasma exchange therapy is as effective as intravenous immune globin therapy for treating Guillain-Barre syndrome.

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Cardiovascular and respiratory support

Many people with Guillain-Barre syndrome will need to be closely monitored in an intensive care unit and given cardiovascular and respiratory support as needed.

  • Difficulty breathing: People who have difficulty breathing on their own may need to be intubated and placed on mechanical ventilation until they can breathe on their own.
  • Arrhythmias: People with abnormal heart rates may need medications or other interventions to normalize their heart rate.
  • Abnormal blood pressure: People with abnormally low blood pressure may need intravenous fluids to maintain their blood pressure, and those with abnormally high blood pressure may need IV medications to reduce their blood pressure.

Pain medications

People with Guillain-Barre syndrome who experience pain from nerve inflammation may benefit from medications to alleviate the pain. Medications that may be used include ibuprofen (Advil, Motrin), naproxen (Aleve), gabapentin (Neurontin), or pregabalin (Lyrica), among others.


After the acute episode of Guillain-Barre syndrome has been managed, many people may benefit from participating in a rehabilitation program. Rehabilitation programs may include physical and/or occupational therapy to help you strengthen muscles and regain function.


Approximately 85 percent of people with Guillain-Barre syndrome will achieve a full recovery by six to 12 months. However, some people will have persistent symptoms, and approximately seven to 15 percent of people will have permanent neurological effects. Many people will also experience persistent fatigue after they recover from the acute disease.

When to seek further consultation

If you develop any symptoms of Guillain-Barre syndrome such as weakness, numbness or tingling, pain in the back or extremities, you should go to your physician. If you are experiencing difficulty breathing, you should go to the emergency department or call an ambulance right away.

Questions your doctor may ask to diagnose

  • Any fever today or during the last week?
  • Are you sick enough to consider going to the emergency room right now?
  • Have you experienced any nausea?
  • Have you been feeling more tired than usual, lethargic or fatigued despite sleeping a normal amount?
  • Have you lost your appetite recently?

Self-diagnose with our free Buoy Assistant if you answer yes on any of these questions.

Hear what 1 other is saying
Once your story receives approval from our editors, it will exist on Buoy as a helpful resource for others who may experience something similar.
The stories shared below are not written by Buoy employees. Buoy does not endorse any of the information in these stories. Whenever you have questions or concerns about a medical condition, you should always contact your doctor or a healthcare provider.
No one KnewPosted January 7, 2024 by L.
My story goes back anywhere from 20-48 yrs of weird pain & symptoms. I spent so many times w/drs trying to figure out what was causing me to be in Excruciating pain. I had problems w/balance after my emergancy c-section 48 yrs ago. I knew something was wrong as i carried my newborn towards the door frame Knowing i was going to hit her head as i knew i was off balance, i managed to cover her head & ended up hurting my arm only as i hit the door frame. From there i had problems w/back pain to the point i couldnt get out of bed for several days. Ive been sick so many times i cant remember them all. I spent 4 weeks n bed about 20yrs ago because the nerves n my feet were in severe pain so much that i laid in bed w/my legs slightly apart not touching A pillow under each knee. By the this 4 wk Incident had happened i had a lot of the health issues describing the causes of GBS. I had severe food Poisoning, vomiting from the flu & later a flu shot. I had severe back pain i had to b carried to r car After laying on the floor while visiting Family whose furniture i couldnt sit in from the pain, the floor was no better. Ive been on steroids to Pain meds. I have had covid. & vomiting for 12 hrs from wearing a fentanyl patch for only an hr, to Crawling out of bed using my fore arms to get to the bathrm. Ive had the Epstein barre virus, whopping cough to anything & everything that was going around. I finally looked up the Epstein barre virus to see if any new info had been added & found Gullian barre syndrome & was beyond struck at what i was reading.I had all the symptoms & was ecstatic when i told my dr what no dr had been able to help me b4.I was diagnosed that day. The problem now is ive fallen 4 times in my slippery socks landed on my coccyx jammed my spine & broke my back. I finally told my dr i have balance issues, certain times i keep running into the door frames, he looked @ me as if i was nuts.Balance problems is 1 of the many symptoms. This was not a neurologist, but my pain dr. He doesnt believe i have GBS & wants me yo prove it. When i have an appt w/him he hits my knees so hard it hurts. But no matter how many times he hits them they dont move. Want to know the worst & scary part is there r no drs who treat GBS, & worse the nurses @ my hospital have no idea what GBS is. Im in trouble. The last time i went to the ER i had terrible pain n the middle of my chest that scared me because it moved Up to the bottom of my neck. The ER dr wanted me to stay because of family heart problems. I realized Much later it was a symptom of GBS, but no one knew how to treat it!!! This is the scariest part. I live in a town of about 40k ppl & yes 1 or 2 medical pol have heard about this syndrome but have nothing for me. im going to have to drive 7 hrs round trip to see a specialist n GBS To get answers & help. I hope for the best & pray for real help. If u want to know what killed Scott Makenzie famous for writing & singing San Francisco, look him up & see what he died from. This GBS is a lot scarier than i initially had thought. Its been since april 2023 that i was diagnosed by my wonderful dr. I just wished drs somewhere along the 20-48yrs could have helped me & said the words “you have Gullian Barre Syndrome & moved on from there. But i didn't have a dr put the dots together. Ppl keep seeing drs until one of them can diagnose u properly. Yes the symptoms dont add up & r scattered but keep going. & go until u find a dr who will do a spinal tap, which is a great test @ determining if u have high proteins in your spinal fluid. They dont hurt, ive had 5 & never got hurt.
Dr. Rothschild has been a faculty member at Brigham and Women’s Hospital where he is an Associate Professor of Medicine at Harvard Medical School. He currently practices as a hospitalist at Newton Wellesley Hospital. In 1978, Dr. Rothschild received his MD at the Medical College of Wisconsin and trained in internal medicine followed by a fellowship in critical care medicine. He also received an MP...
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