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Viagra or Levitra: Which Erectile Dysfunction Treatment Fits Your Body Better?

Viagra vs Levitra
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Written by Andrew Le, MD.
Medically reviewed by
Last updated January 13, 2026

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Erectile dysfunction can affect confidence, relationships, and daily life. Many men look for reliable treatments that work fast, last long enough, and feel safe to use.

Two of the most prescribed options are Viagra and Levitra. Both are designed to help improve blood flow to the penis so erections are easier to achieve and maintain during sexual activity. While they may look similar on the surface, they behave differently inside the body.

These differences can matter more than you might expect, especially when age, health conditions, and side effects come into play.

How do Viagra and Levitra actually help with erections?

Before comparing results, it helps to understand what happens inside the body. Both medications support natural erection signals rather than forcing an automatic response.

To make this clearer, let’s look at each option on its own.

How Viagra supports blood flow

Viagra works by strengthening the body’s natural response to sexual stimulation. When arousal happens, the body releases nitric oxide. This chemical activates another enzyme that raises levels of cyclic guanosine monophosphate, also called cGMP. Higher cGMP levels relax smooth muscle tissue in the penis. As a result, more blood flows in, and pressure builds enough to create an erection.

Viagra does not relax muscles by itself. Instead, it blocks an enzyme called phosphodiesterase type 5, or PDE5. PDE5 normally breaks down cGMP. When this enzyme is blocked, cGMP stays active longer. This helps erections last long enough for sexual activity.

Viagra is selective for PDE5, but it also affects another enzyme involved in vision, called PDE6. Because of this, some men notice changes in color vision or increased light sensitivity.

How Levitra works inside the body

Levitra follows the same general pathway. It also blocks PDE5, which helps maintain higher cGMP levels in the penis during sexual stimulation. The end result is improved blood flow and stronger erections.

Where Levitra stands out is its precision. Laboratory testing shows that Levitra is much more selective for PDE5 and far less active on enzymes linked to vision or other body systems. This higher selectivity helps explain why fewer users report vision-related side effects.

Just like Viagra, Levitra requires sexual arousal to work. Without stimulation, the chemical signals that start the process never activate.

Which medication works better for most men?

Effectiveness matters. Men want to know whether a medication will actually help them achieve and maintain erections in real-life situations.

Clinical research gives useful answers.

What studies show about Viagra’s results

Viagra has been studied for decades. In controlled trials, nearly 70% of men using Viagra reported successful intercourse. In comparison, only about one in five men on placebo achieved the same result.

Men using Viagra also experienced more frequent success. On average, they reported nearly six successful sexual encounters per month. Placebo users reported fewer than two.

Additional research confirmed these findings across different ages and health conditions. After several weeks of use, nearly half to over 80% of men reported improved erections, depending on their health group.

Viagra also works well for men with specific challenges. Men with diabetes showed clear improvements compared to placebo. Men who had nerve-sparing prostate surgery also responded strongly. These results show that Viagra remains effective across a wide range of situations.

What research reveals about Levitra’s effectiveness

Levitra delivers similarly strong, and sometimes broader, results.

In studies using flexible dosing, most men experienced clear improvements in erection quality within weeks. Scores measuring erectile function increased steadily, while placebo groups showed little change.

More than 80% of men taking Levitra reported improved erections. Success rates for penetration and erection maintenance were also much higher than placebo.

Age did not reduce Levitra’s effectiveness. In pooled studies including more than 1,300 men, erectile function scores improved in younger and older groups alike. Men over 65 experienced gains similar to those seen in younger users. Positive responses increased with age, which shows that Levitra remains reliable even as the body changes over time.

How fast do Viagra and Levitra start working?

Timing can influence satisfaction. Many men want a medication that works quickly without long waiting periods.

Here’s how each option performs.

How quickly Viagra takes effect

Viagra typically starts working within 30 minutes. In studies using a 50 mg dose, many men achieved erections firm enough for penetration in under half an hour. Some responded in as little as 12 minutes.

Most men reached effective rigidity within 45 minutes. This makes Viagra a reliable option when planning intimacy ahead of time.

As for duration, Viagra continues working for up to four hours. Even when sexual activity started several hours after dosing, many men still achieved usable erections. This allows flexibility without rushing.

How fast Levitra works

Levitra shows a very rapid onset for many users. Research found that some men achieved successful intercourse within 10 minutes of taking the medication.

Within 25 minutes, about half of men using standard doses reported successful erections. Placebo users lagged far behind.

The orally disintegrating tablet form also acts quickly. Success rates were already high within the first 15 minutes and continued improving over the next half hour. This makes Levitra appealing for men who prefer faster results.

How should each medication be taken safely?

Using these medications correctly improves results and reduces risks.

Before diving into specifics, it helps to understand that neither option causes an automatic erection.

Viagra dosing and use guidelines

Viagra is taken as needed. Most men start with 50 mg about 30 minutes to one hour before sex. It can be taken up to four hours in advance, which offers planning flexibility.

Viagra should not be used more than once per day. It comes in tablet form and as a liquid suspension. When using the liquid, accurate measuring tools are essential.

Sexual stimulation is required for Viagra to work. Alcohol and grapefruit products should be limited since they may increase side effects.

Viagra should not be confused with Revatio, which is used for pulmonary arterial hypertension. These two products should never be combined.

Levitra dosing and special considerations

Levitra is usually taken once daily, about 60 minutes before sexual activity. The standard starting dose is 10 mg. Some men may increase to 20 mg or reduce to 5 mg depending on response and tolerance.

Men aged 65 and older typically start with 5 mg. Those using alpha blockers also begin at lower doses.

Levitra comes in tablet form and as an orally disintegrating tablet. The disintegrating tablet should not be taken with liquid and is not interchangeable with the regular tablet.

Liver health affects dosing. Moderate liver issues require lower maximum doses, while severe liver disease makes Levitra unsuitable. Kidney problems usually do not require dose changes unless dialysis is involved.

Certain medications that affect liver enzymes can significantly increase Levitra levels. In these cases, dosing must be reduced and spaced carefully.

What side effects should you expect?

Side effects vary from person to person. Knowing what may occur helps set realistic expectations.

Common and serious side effects of Viagra

Common reactions include headaches, flushing, nasal congestion, heartburn, nausea, diarrhea, muscle pain, and back pain. Some men notice tingling in their limbs or mild nosebleeds.

Vision changes can occur. These include seeing a blue tint, difficulty distinguishing colors, or light sensitivity.

Serious effects are rare but require urgent care. These include sudden vision or hearing loss, chest pain, fainting, severe dizziness, breathing problems, allergic reactions, and erections lasting longer than four hours.

Levitra side effects to be aware of

Levitra commonly causes headaches, flushing, stomach upset, heartburn, nasal congestion, and flu-like symptoms.

Serious side effects mirror those of Viagra. These include prolonged erections, sudden vision or hearing changes, fainting, allergic swelling, breathing difficulty, and skin reactions.

Levitra tends to cause fewer muscle and stomach complaints, which may matter for men sensitive to those issues.

So, which one is better for you?

  • Viagra may be the better option if you want a long-established medication, flexible timing, and lower overall cost.
  • Levitra may be the better choice if you want faster onset, strong effectiveness across all ages, and fewer vision or muscle-related side effects.
  • Both medications require sexual stimulation and do not work automatically.
  • Both improve erection quality significantly when used correctly and under medical guidance.
  • Your age, health conditions, and other medications play a major role in deciding which option fits you best.
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The stories shared below are not written by Buoy employees. Buoy does not endorse any of the information in these stories. Whenever you have questions or concerns about a medical condition, you should always contact your doctor or a healthcare provider.
Jeff brings to Buoy over 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medi...
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References

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