Skip to main content

Bio Complete 3 Reviews: Is it Worth Your Money?

Written by Andrew Le, MD

UpdatedFebruary 22, 2024

In recent years, probiotic-based supplements have gained immense popularity for their potential to improve gut health, boost immunity, and address issues such as obesity and mental health. According to studies, probiotics or prebiotics are among the most commonly used dietary supplements after vitamins and minerals among adults.

Bio Complete 3 is a dietary supplement that claims to support digestive health through a three-pronged approach. The supplement combines prebiotics, probiotics, and postbiotics to promote a healthy gut microbiome and improve digestion and immune health. In this review, we will delve into the science behind Bio Complete 3 and share our analysis and testing experiences with the product, helping you to determine if it's the right choice for you.

Bio Complete 3

Order Bio Complete 3 Now

What is Bio Complete 3?

Bio Complete 3 is a probiotic-based dietary supplement that is designed to support weight management, easier digestion, boosted energy, and fewer unhealthy cravings. It is formulated with a combination of prebiotics, probiotics, and postbiotics, which are intended to support “good” bacteria and combat harmful pathogens, lectins, and gut yeasts.

Each bottle of Bio Complete 3 contains a one-month supply of capsules that are taken once daily. Each serving consists of two capsules, preferably taken with a meal. The supplement is manufactured by Gundry MD, a company founded by Dr. Steven Gundry, a heart surgeon with over 30 years of experience.

Dr. Gundry's "Holobiotics" approach involves administering a combination of prebiotics, probiotics, and postbiotics to support overall gut health and healthy weight management. In addition to Bio Complete 3, Gundry MD produces a range of products aimed at gut health and weight management, including lectin-free, gut-friendly foods, topical skin products, nutritional supplements, and powder shake blends.

The majority of online customer reviews of Bio Complete 3 are positive, with most 5-star reviews reporting an improvement in digestion and energy. Some customers also mention a reduction in unhealthy cravings or weight loss. Negative customer reviews typically come from those who have experienced unpleasant side effects, such as bloating or gas, which can occur when starting a probiotic supplement. Overall, Bio Complete 3 is a dietary supplement that aims to support overall gut health and healthy weight management.

Click Here to Order Bio Complete 3

How Bio Complete 3 Works

We’ve broken down the three main components of Bio Complete 3 and how they may benefit you.


Probiotics are live “good” bacteria that restore and replenish your gut flora and are generally considered safe when taken as supplements. Bio Complete 3 includes 22mg of a Bacillus coagulans (ProDURA) and Bifidobacterium bifidum UABb-10 blend in each daily dose.

B. coagulans (ProDURA) is unique due to its outer shell that protects it from harsh environments, allowing it to withstand bile and stomach acid before being absorbed into the large intestine. This allows you to take less per serving since the organism is more resilient than most. The recent addition of B. bifidum UABb-10 to Bio Complete 3 provides more digestive support and promotion of a healthy gut microbiota composition. The product contains 2 billion CFU per serving, which is right in line with the effective dosage used in scientific studies for digestive health.


Prebiotics are compounds found in food that stimulate the growth of beneficial microorganisms in the gut microbiome. When prebiotics are fermented by bacteria in the large intestine, they are broken down into short-chain fatty acids (SCFAs), which play a role in multiple processes in the gut. SunFiber is a soluble fiber made from hydrolyzed guar gum and constitutes the prebiotic component of Bio Complete 3, along with acacia gum (from CoreBiome). SunFiber claims to provide a healthy satiety effect and help with diarrhea and constipation, along with its prebiotic function. It’s also a low-FODMAP-certified product, unlike most high-fiber foods.

Numerous studies have looked at guar fiber, showing its role in maintaining proper bowel movements and treating symptoms associated with irritable bowel syndrome. Acacia gum, another soluble fiber, has recognized functionality as a prebiotic support for beneficial gut bacteria, as well. However, the daily dosage in Bio Complete 3 is just 450mg (0.45g), which is lower than the daily intake of 5-10g of either guar fiber or acacia gum for digestive support.


Postbiotics are byproducts made by the healthy bacteria in your gut. They provide benefits to our GI tract and beyond. Postbiotics can be inanimate organisms or components like amino acids or vitamins B and K. They can also include short-chain fatty acids like butyrate that play a role in intestinal immunity. Bio Complete 3's postbiotic component is tributyrin (from CoreBiome), with 300mg in each daily dose.

CoreBiome supports butyrate levels in the body, thereby supporting your intestinal lining, offering immune support and relief from digestive issues like bloating, loose stools, constipation, and gas. Short-chain fatty acids like butyrate have also been documented to have an anti-obesity effect. While there is extensive research data published on the benefits of butyrate, most studies on tributyrin itself have been either conducted on animals or performed in unpublished clinical trials for the manufacturer. When considering dosage, the amount of tributyrin in Bio Complete 3 has been well researched as butyrate and is considered an effective, safe dose.

Using Bio Complete 3

Gundry MD recommends taking Bio Complete 3 every day on a consistent basis. The supplement is designed to be taken once a day (two capsules), preferably before a meal. If you forget a dose, simply resume your schedule the next day.

Click Here to Order Bio Complete 3

Who Should Take Bio Complete 3?

Bio Complete 3 is a dietary supplement that can provide benefits to anyone looking to improve their digestive health. The combination of fiber, probiotics, and tributyrin can work together to support gut lining and boost the immune system. Research suggests that probiotics can help improve digestion and reduce gastrointestinal discomfort by promoting the growth of "good" bacteria.

If you have experienced dysbiosis, which is an imbalance of microorganisms in the gut, Bio Complete 3's pre- and postbiotics can help restore your gut to its healthy balance. However, those with compromised immune systems or severe illnesses should consult their doctor before taking any new supplement.

In summary, Bio Complete 3 is a safe and effective supplement that can benefit anyone looking to improve their digestive health. However, those with severe illnesses or compromised immune systems should consult their doctor before taking this supplement.

Click Here to Order Bio Complete 3

Is Bio Complete 3 Safe?

We understand that safety is a top concern when considering a new supplement. The good news is that the dosages of the active ingredients in Bio Complete 3 are all within safe limits and have been used in scientific research studies.

However, starting a new probiotic regimen can cause typically mild side effects. Some common side effects you may experience with Bio Complete 3 or any probiotic or fiber supplement include passing gas more often, bloating, indigestion or mildly upset stomach, and loose stool. These side effects typically resolve within a couple of days of starting a new probiotic supplement.

It's important to note that Bio Complete 3 is manufactured in the United States with domestic and imported ingredients, and an independent third-party laboratory is utilized to confirm product quality. As with all nutritional supplements, we recommend consulting your doctor before beginning a new regimen.

We also want to mention that some people, such as those with mast cell activation syndrome (MCAS), can sometimes experience negative reactions to very common fillers found in supplements and medications. Bio Complete 3 contains cellulose as filler, so if you know or suspect you are susceptible to this kind of reaction, you should instead consider a competing product that has no fillers, such as Peak Performance Synbiotic.

Overall, we believe that Bio Complete 3 is safe for most people when taken as directed. As with any dietary supplement, it's important to listen to your body and consult with a healthcare professional if you have any concerns.

Is Bio Complete 3 a Good Value?

When it comes to purchasing Bio Complete 3, there are a few things to consider in terms of value. First off, it's important to note that you can only purchase Bio Complete 3 through the Gundry MD website or Amazon. The company advises against purchasing from third-party retailers to ensure authenticity.

If you decide to purchase Bio Complete 3 from the Gundry MD website, you can save money by signing up for their free VIP membership. As a VIP member, you'll receive special deals and discounts, and you can set up regular monthly refills automatically. Even if you don't sign up for VIP membership, you can still save money by purchasing in bulk.

Compared to other probiotic-based nutritional supplements with pre-, pro-, and postbiotic ingredients, Bio Complete 3's cost falls on the higher end, even when taking into account the discounts available with a free VIP membership. Sandhus Nutrition GUT Health, for example, has a nearly identical ingredient list and is slightly less expensive than Bio Complete 3. However, when you factor in VIP memberships and subscribe and save options, they become more comparable in cost.

It's worth noting that there are other probiotic-based nutritional supplements available for less than Bio Complete 3 that also include clinically proven bacterial strains, along with pre- and postbiotic ingredients. All of the products on our list are third-party tested for quality and safety, and most offer subscribe and save deals, making Bio Complete 3's expense seem a little less justified.

To summarize, Bio Complete 3 is a relatively expensive nutritional supplement, even with the discounts available through a free VIP membership. While it does contain pre-, pro-, and postbiotic ingredients, there are other products available that offer similar benefits for less money. Ultimately, the decision to purchase Bio Complete 3 comes down to whether or not you are targeting specific ingredients.

Click Here to Order Bio Complete 3

Alternatives to Bio Complete 3

When it comes to gut health supplements, there are several alternatives to Bio Complete 3 that offer similar pre-, pro-, and postbiotic components. Here are three options to consider:

Sandhus Nutrition GUT Health

Sandhus Nutrition GUT Health is a product that closely mirrors Bio Complete 3's formulation. It contains 1,000mg CoreBiome (300mg tributyrin), 500mg L-glutamine (KQ), 200mg SunFiber, and.2 billion CFU Lactospore (Bacillus coagulans MTCC 5856). In addition to pre-, pro-, and postbiotic components, GUT Health includes L-glutamine to support a healthy gut lining. Other ingredients include a delayed-release vegetable capsule, silicon dioxide, and MCT powder.

A 30-day supply of GUT Health costs $59.95 for a one-time purchase, compared to Bio Complete 3 at $69.95. Sandhus Nutrition offers a subscribe and save option that will save you 15% as well as bulk purchasing options to help reduce the cost. A daily serving consists of four capsules. Sandhus Nutrition matches Gundry MD with its safety and convenience considerations; both companies are 3rd-party tested, use GMP-certified facilities for manufacturing, and offer a 90-day money-back guarantee.

Core Nutritionals Core GUT

Core Nutritionals offers a comprehensive gut support product called Core GUT. Similar to Bio Complete 3, the company utilizes SunFiber as a prebiotic and CoreBiome (300mg tributyrin) as a postbiotic. Core Nutritionals includes 1,000mg SunFiber, which is more in line with beneficial and researched dosages than what Bio Complete 3 offers. The probiotic component of Core GUT is a blend of 17 different strains of bacteria, including species from Bifidobacterium, Lactobacillus, and Saccharomyces, which are all thoroughly researched genera. Core GUT also includes digestive enzymes (a blend of protease, lactase, amylase, and lipase) in its formula.

One downside to Core GUT is the serving size. While you get a large number of CFUs per capsule, you have to take five capsules daily to reach a whole serving. A 30-day supply of Core Nutritionals Core GUT will cost you $54.99, and there are no bulk-purchasing or subscription options currently available. The company has a short 30-day return window and only offers free shipping for orders over $125.

Peak Performance Synbiotic

Peak Performance Synbiotic is another option that offers pre-, pro-, and postbiotic ingredients for a 3-in-1 digestive health support supplement. Peak Performance uses scientifically backed xylooligosaccharides (XOS) as its prebiotic, which is different from Bio Complete 3. The company’s probiotic blend also contains Bacillus species like Bio Complete 3, although the product label does not specify down to the strain level and does not give the quantity in CFU per serving. For the postbiotic component, Peak Performance Synbiotic incorporates CoreBiome tributyrin. One perk of this product is its lack of fillers; the only “other ingredient” on the label is the vegan capsule.

Peak Performance Synbiotic is not as expensive as products like Bio Complete 3 or Sandhus Nutrition GUT Health. One bottle of 30 servings costs only $33.95, with opportunities for savings through bulk-purchasing and subscribe and save programs. However, it’s worth noting that the CFU per serving of probiotics is unknown, so you really don’t know exactly how much you are getting in every capsule. Peak Performance also has a tight return window; you only have 30 days to take advantage of the money-back guarantee if the product does not work for you.

Click Here to Order Bio Complete 3

Frequently Asked Questions about Bio Complete 3

At Innerbody, we understand that you may have some questions about Bio Complete 3 before you decide to try it. Here are some frequently asked questions to help you make an informed decision.

What is Bio Complete 3?

Bio Complete 3 is a dietary supplement created by Gundry MD. It is designed to support gut health by providing a blend of prebiotics, probiotics, and postbiotics. The supplement contains a variety of ingredients, including Tributyrin, Sunfiber, Bacillus coagulans, and more.

How does Bio Complete 3 work?

Bio Complete 3 works by providing a variety of beneficial bacteria, prebiotics, and postbiotics to the gut. These ingredients work together to support digestive health, boost energy levels, and reduce unhealthy food cravings. The supplement also contains Tributyrin, which is a short-chain fatty acid that supports gut health and may help reduce inflammation.

What are the benefits of taking Bio Complete 3?

The benefits of taking Bio Complete 3 may include improved digestive health, increased energy levels, reduced food cravings, and reduced inflammation. The supplement may also support weight loss and help manage symptoms associated with irritable bowel syndrome (IBS) and constipation.

Are there any side effects of taking Bio Complete 3?

Bio Complete 3 is generally considered safe for most people. However, some users may experience mild digestive discomfort, such as bloating or gas, when they first start taking the supplement. These side effects are usually temporary and should subside within a few days.

Is Bio Complete 3 suitable for vegetarians or vegans?

Bio Complete 3 is suitable for vegetarians, but it is not suitable for vegans. The supplement contains Tributyrin, which is derived from butterfat.

How do I take Bio Complete 3?

To take Bio Complete 3, simply mix one scoop of the powder with water or your favorite beverage. It is recommended that you take the supplement once per day, preferably with a meal.

Is there a money-back guarantee for Bio Complete 3?

Yes, Gundry MD offers a 90-day money-back guarantee for Bio Complete 3. If you are not satisfied with the supplement, you can return it for a full refund within 90 days of purchase.

Where can I buy Bio Complete 3?

Bio Complete 3 is available for purchase on the Gundry MD website. You can also find the supplement on Amazon and other online retailers. It is important to purchase the supplement from a reputable source to ensure that you are getting a genuine product.

Can I take Bio Complete 3 with other medications?

If you are taking any medications, it is important to consult with your healthcare provider before taking Bio Complete 3. Some ingredients in the supplement may interact with certain medications, so it is important to check with your doctor before adding it to your routine.

Is Bio Complete 3 backed by scientific research?

While some of the ingredients in Bio Complete 3 have been studied for their potential health benefits, more research is needed to fully understand the supplement's effects. However, many users have reported positive results after taking the supplement, and Gundry MD offers a money-back guarantee if you are not satisfied with the product.

Click Here to Order Bio Complete 3

Affiliate Disclosure:
The links provided may earn us a small commission at no additional cost to you if you choose to purchase the recommended product. This support allows our research and editorial team to continue providing high-quality recommendations. As a participant in the Amazon Services LLC Associates Program, an affiliate advertising initiative, we are able to earn advertising fees through providing links to products on Please rest assured that we only recommend high-quality products.