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Cimzia (Certolizumab): Uses, Dosage, Side Effects, Warnings

UpdatedMay 29, 2024

Cimzia (Certolizumab) is a medication used to treat Crohn's disease, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. It is a prescription drug that reduces the effects of a substance in the body that can cause inflammation. Cimzia is used to treat the symptoms of Crohn's disease after other treatments have failed.

Dosage and administration of Cimzia vary depending on the condition being treated. The medication is administered by injection, either by a healthcare provider or by the patient themselves after proper training. Cimzia is typically given every two to four weeks, depending on the condition being treated.

While Cimzia can be an effective treatment for several conditions, it can also cause side effects and may not be appropriate for everyone. It is important to discuss the risks and benefits of Cimzia with a healthcare provider before starting treatment.

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Key Takeaways

  • Cimzia is a prescription medication used to treat Crohn's disease, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.
  • Dosage and administration of Cimzia vary depending on the condition being treated and are typically given every two to four weeks.
  • Cimzia can cause side effects and may not be appropriate for everyone, so it is important to discuss the risks and benefits with a healthcare provider before starting treatment.

Cimzia (Certolizumab)

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What is Cimzia (Certolizumab)

Cimzia (Certolizumab Pegol) is a prescription medication that belongs to a class of drugs called TNF blockers. It is used to treat a variety of autoimmune disorders such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, and plaque psoriasis. Cimzia works by blocking the action of tumor necrosis factor-alpha (TNF-alpha), which is a protein produced by the immune system that causes inflammation.

Cimzia is administered via subcutaneous injection. The dosage and frequency of injections depend on the specific condition being treated. The medication is available in pre-filled syringes and autoinjectors.

Cimzia is approved by the Food and Drug Administration (FDA) for the treatment of the above-mentioned autoimmune disorders. It is important to note that Cimzia can increase the risk of serious infections, including tuberculosis and bacterial sepsis. Therefore, patients should be monitored closely for signs of infection and should not receive the medication if they have an active infection.

Overall, Cimzia is a well-tolerated medication that has shown to be effective in treating a variety of autoimmune disorders. However, as with any medication, patients should discuss the risks and benefits of Cimzia with their healthcare provider before starting treatment.

Uses of Cimzia

Cimzia (Certolizumab) is a prescription drug that is used to treat various autoimmune disorders. The drug is a TNF blocker that reduces the effects of a substance in the body that can cause inflammation.

Cimzia is primarily used to treat the symptoms of Crohn's disease after other treatments have failed. It is also used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. In addition, Cimzia is used to treat non-radiographic axial spondyloarthritis, a type of arthritis that affects the spine and can cause back pain and stiffness.

For Crohn's disease, Cimzia is used to reduce signs and symptoms and maintain clinical response in adult patients with moderately to severely active disease. For rheumatoid arthritis, Cimzia is used to reduce signs and symptoms of moderate to severe disease in adult patients who have not responded well to other treatments. For psoriatic arthritis, Cimzia is used to reduce signs and symptoms of active arthritis in adult patients. For ankylosing spondylitis, Cimzia is used to reduce signs and symptoms in adult patients with active disease. For plaque psoriasis, Cimzia is used to treat moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy.

The drug is administered by subcutaneous injection and is available in pre-filled syringes or auto-injectors. The dosage of Cimzia varies depending on the condition being treated and the patient's individual response to the drug. It is important to follow the dosage instructions provided by a healthcare professional.

Overall, Cimzia is a versatile drug that can be used to treat a range of autoimmune disorders. It is important to discuss the potential benefits and risks of Cimzia with a healthcare professional to determine if it is the right treatment option for a particular individual.

Dosage and Administration

Cimzia (Certolizumab) is administered by subcutaneous injection. It is important to follow the dosage instructions provided by your healthcare provider or pharmacist.

The recommended dose for Cimzia is 400 mg initially and at weeks 2 and 4, followed by a maintenance dose of 200 mg every other week. The medication comes in prefilled syringes and should only be administered by a healthcare provider or under their supervision.

Before administration, the medication should be allowed to warm up to room temperature for approximately 30 minutes. The injection site should be cleaned with an alcohol swab and allowed to dry before injection.

The injection should be administered into the thigh or abdomen, rotating the injection site each time. The medication should not be injected into areas of the skin that are tender, bruised, red, or hard.

It is important to dispose of used syringes properly and to not reuse syringes or needles. If a dose is missed, it should be administered as soon as possible. However, if it is close to the time for the next scheduled dose, the missed dose should be skipped and the regular dosing schedule should be resumed.

Overall, it is important to follow the prescribed dosage and administration instructions provided by your healthcare provider or pharmacist to ensure the safe and effective use of Cimzia.

Side Effects of Cimzia

As with any medication, Cimzia (Certolizumab) may cause side effects. Some of these side effects are common, while others are more serious and require immediate medical attention. It is important to be aware of the potential side effects of Cimzia and to report any unusual symptoms to your doctor.

Common side effects of Cimzia include:

  • Diarrhea
  • Joint pain
  • Pain and swelling at the injection site
  • Rash or redness at the injection site
  • Weight gain

If any of these side effects persist or worsen, contact your doctor immediately.

More serious side effects of Cimzia may include:

  • Fever
  • Tiredness
  • Skin rash
  • Burning, itching, numbness, or tingling sensations
  • Loss of appetite
  • Dizziness or weakness

If you experience any of these serious side effects, seek medical attention immediately.

In rare cases, Cimzia may cause serious side effects, including:

  • Infections
  • Cancer
  • Liver problems
  • Blood disorders
  • Nervous system disorders

If you experience any of these serious side effects, seek medical attention immediately.

It is important to note that this is not a complete list of all possible side effects of Cimzia. If you experience any unusual symptoms while taking Cimzia, contact your doctor immediately.

Warnings and Precautions

Before taking Cimzia, it is important to be aware of the potential risks and warnings associated with this medication. Cimzia should not be used if you are allergic to certolizumab or any of its ingredients. Additionally, Cimzia should not be used if you have an active infection, including tuberculosis, or if you have a history of hepatitis B.

Cimzia may increase the risk of developing certain types of cancer, including lymphoma. It is important to discuss any history of cancer with your healthcare provider before starting treatment with Cimzia. Additionally, Cimzia may increase the risk of seizures in patients with a history of multiple sclerosis.

If you are pregnant or breastfeeding, it is important to discuss the potential risks and benefits of using Cimzia with your healthcare provider. Cimzia may increase the risk of bleeding, and it is important to inform your healthcare provider if you are taking any medications that may increase the risk of bleeding.

Injection site reactions, including pain, redness, itching, and swelling, are common with Cimzia. It is important to inform your healthcare provider if you experience any signs and symptoms of a serious infection, including fever, chills, cough, skin sores, shortness of breath, weight loss, diarrhea, or painful urination.

Cimzia works by blocking tumor necrosis factor (TNF), a protein that plays a role in inflammation. While Cimzia can be effective in treating inflammation, it may also increase the risk of serious infections. If you have a history of congestive heart failure, it is important to discuss the potential risks and benefits of using Cimzia with your healthcare provider.

In summary, Cimzia is a medication that can be effective in treating inflammation, but it is important to be aware of the potential risks and warnings associated with this medication. It is important to discuss any concerns or questions with your healthcare provider before starting treatment with Cimzia.

Storage and Handling

Cimzia (Certolizumab) should be stored in the refrigerator at a temperature of 2°C to 8°C (36°F to 46°F) until ready to use. Do not freeze the medication. If the medication has been frozen, do not use it and contact your healthcare provider.

Before use, allow the medication to reach room temperature by placing it in its original packaging on a flat surface for 30 minutes. Do not shake the medication.

Cimzia is supplied in single-use prefilled syringes or autoinjectors. Each syringe or autoinjector is for one-time use only. Do not reuse syringes or autoinjectors. Discard any unused medication.

If you need to transport Cimzia, it can be stored at room temperature (up to 25°C or 77°F) for up to 7 days. If the medication is not used within 7 days, it should be discarded. Avoid exposing the medication to direct sunlight and extreme temperatures.

Always keep Cimzia out of the reach of children and pets. If you have any questions about the storage or handling of Cimzia, contact your healthcare provider or pharmacist.

Interactions with Other Drugs

When taking Cimzia (Certolizumab), it is important to be aware of potential interactions with other drugs. Some drugs may interact with Cimzia and increase the risk of side effects or reduce its effectiveness.

One important drug to be aware of is methotrexate. Methotrexate is a commonly used drug for the treatment of rheumatoid arthritis and psoriasis. When taken with Cimzia, it may increase the risk of infections and liver damage. Corticosteroids are another class of drugs that may interact with Cimzia. Corticosteroids such as prednisone may increase the risk of infections and reduce the effectiveness of Cimzia.

Certolizumab pegol is the active ingredient in Cimzia and should not be taken with other biologic drugs such as anakinra, abatacept, rituximab, or natalizumab. Taking these drugs together may increase the risk of serious infections.

It is also important to be aware of potential interactions with vaccines. Live vaccines should not be taken while on Cimzia as they may cause infections. It is recommended to receive all necessary vaccines prior to starting treatment with Cimzia.

Etanercept and kineret are other biologic drugs that should not be taken with Cimzia. Taking these drugs together may increase the risk of serious infections.

Orencia and rituxan are other drugs that may interact with Cimzia. When taken together, they may increase the risk of infections.

It is important to inform your doctor of all medications, including prescription and over-the-counter drugs, and supplements you are taking before starting treatment with Cimzia. Your doctor may need to adjust your dosage or monitor you more closely for potential side effects.

Clinical Studies and Effectiveness

Cimzia (Certolizumab) is a medication used to treat autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. It is also used to treat Crohn's disease after other treatments have failed.

Clinical studies have shown that Cimzia is an effective treatment for these conditions. In a study of patients with rheumatoid arthritis, Cimzia was found to be more effective than a placebo in reducing symptoms such as joint pain and swelling. Another study found that Cimzia was effective in treating psoriatic arthritis, with patients experiencing significant improvement in symptoms such as joint pain and skin lesions.

In addition to its effectiveness in treating autoimmune conditions, Cimzia has also been studied for its use in treating inflammatory bowel disease. A study of patients with Crohn's disease found that Cimzia was effective in inducing and maintaining remission of the disease.

Cimzia is typically administered by injection under the skin. The dosage and frequency of injections will vary depending on the condition being treated and the individual patient's response to the medication. It is important to follow the dosing instructions provided by your healthcare provider.

Like all medications, Cimzia may cause side effects. Common side effects include injection site reactions, upper respiratory infections, and headaches. In rare cases, more serious side effects such as infections and allergic reactions may occur. It is important to discuss any concerns or questions about potential side effects with your healthcare provider.

Overall, Cimzia has been shown to be an effective treatment for autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis, as well as Crohn's disease. Clinical studies have demonstrated its effectiveness in reducing symptoms and inducing and maintaining remission. As with any medication, it is important to discuss the risks and benefits of treatment with your healthcare provider.

Special Considerations

When taking Cimzia, there are some special considerations to keep in mind. It is important to inform your healthcare provider of any medical conditions you have or medications you are taking before starting Cimzia.

Cimzia can affect your immune system, making you more susceptible to serious infections. If you have a history of serious infections or are currently experiencing an infection, your healthcare provider may advise against taking Cimzia. Additionally, if you have hepatitis B virus, Cimzia may cause the virus to become active again. Your healthcare provider may recommend monitoring your liver function while taking Cimzia.

Some common side effects of Cimzia include chills, cough, and fungal infections. However, if you experience any serious infections while taking Cimzia, seek medical attention immediately. Cimzia may also cause anemia, so your healthcare provider may recommend regular blood tests to monitor your hemoglobin levels.

If you have diabetes or HIV, Cimzia may affect your blood sugar levels. Your healthcare provider may recommend monitoring your blood sugar levels more frequently while taking Cimzia.

If you have lupus or are pregnant, talk to your healthcare provider before taking Cimzia. There is limited data on the safety of Cimzia in these populations, and your healthcare provider can help you weigh the risks and benefits of taking Cimzia.

Lastly, if you experience joint pain or swelling while taking Cimzia, inform your healthcare provider as this may be a sign of a serious side effect.

Overall, it is important to follow your healthcare provider's instructions while taking Cimzia and to inform them of any changes in your health or any new medications you are taking.

Frequently Asked Questions

1. How long do Cimzia side effects typically last?

Cimzia side effects can vary in duration and severity depending on the individual. Some side effects may last only a few days, while others may persist for several weeks. It is important to report any side effects to your doctor, who can advise you on how to manage them.

2. What are the most common side effects of Cimzia?

The most common side effects of Cimzia include injection site reactions, upper respiratory infections, and headaches. Other possible side effects include nausea, abdominal pain, and fatigue. If you experience any of these side effects, it is important to speak with your doctor.

3. Can Cimzia cause stomach problems?

Yes, Cimzia can cause stomach problems, including nausea, abdominal pain, and diarrhea. If you experience any of these symptoms, it is important to notify your doctor.

4. What are the potential eye-related side effects of Cimzia?

Cimzia may cause eye-related side effects, such as blurred vision, dry eyes, and eye pain. In rare cases, it may also cause serious eye problems, such as uveitis or optic neuritis. If you experience any changes in your vision or eye pain, it is important to seek medical attention immediately.

5. Are there any ongoing lawsuits related to Cimzia?

There are currently no ongoing lawsuits related to Cimzia. However, if you believe you have suffered harm as a result of taking Cimzia, it is important to speak with an attorney who can advise you on your legal options.

6. Are there any pictures available of rashes caused by Cimzia?

We were unable to locate any pictures of rashes specifically caused by Cimzia. However, if you experience a rash or any other skin reaction while taking Cimzia, it is important to speak with your doctor.

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