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Processed to Death: Startling Study Links Ultra-Processed Foods to Major Health Hazards

Written by Andrew Le, MD

UpdatedMarch 28, 2024

A recently published medical journal has presented an in-depth review of the health risks associated with the consumption of ultra-processed foods. Here's a synopsis of the findings, presented in a way that's approachable and understandable for a general audience.

The Big Picture: What Are Ultra-Processed Foods?

"Ultra-processed" refers to a category of foods defined by the NOVA food classification system. These are items like your packaged snacks, carbonated drinks, instant noodles, and ready-made meals. They're chiefly made up of substances that are chemically altered from their original form found in foods, alongside a variety of additives to improve their taste, texture, longevity, and appearance. This often comes at the cost of including very few to no whole foods at all.

Why Should We Be Concerned?

The shift towards these ultra-processed foods has been gaining pace globally. Consumption patterns show that in affluent countries like Australia and the US, between 42% to 58% of our dietary energy comes from ultra-processed foods. The numbers are lower in countries like Italy and South Korea but are increasing rapidly, particularly in densely populated, developing nations.

Diet quality and health could be on the line. Ultra-processed foods often feature potentially concerning food matrices and textures, potential contaminants from packaging, additives and other ingredients not typically found in minimally processed or unprocessed foods. They're usually high in energy, salt, sugar, and saturated fats, while low in fiber, micronutrients, and vitamins. New evidence suggests that this combination might pose a cumulative risk for chronic inflammatory diseases, possibly through altering the gut microbiome or increasing inflammation.

The Review: A Closer Look at the Facts

The researchers conducted what's known as an umbrella review. This is essentially a review of reviews, pooling together findings from multiple studies — specifically, they looked at systematic reviews and meta-analyses of various types of studies that met certain eligibility criteria. They evaluated the evidence based on a set of predetermined classification criteria: convincing (class I), highly suggestive (class II), suggestive (class III), weak (class IV), or no evidence (class V). The quality of the evidence was then rated using a framework known as GRADE, which assesses evidence as high, moderate, low, or very low quality.

The Hard Truth: What Did They Find?

The review encompassed 45 unique pooled analyses, covering more than 9.8 million participants. It found associations between ultra-processed food consumption and 32 health outcomes — which spanned the gamut from mortality, cancer, mental, respiratory, cardiovascular, gastrointestinal to metabolic health. The strongest direct associations with ultra-processed food intake were linked to increased risk of cardiovascular disease mortality, type 2 diabetes, prevalent anxiety outcomes, and combined common mental disorders.

  • For cardiovascular disease mortality, the risk was 50% higher.
  • For type 2 diabetes, the dose-response risk ratio was 1.12, meaning each incremental increase in consumption increased the risk.
  • People with a higher intake of ultra-processed foods showed an approximately 48% higher likelihood of anxiety outcomes.
  • There was a 53% higher risk concerning common mental health disorders.

There was also highly suggestive evidence linking higher consumption to a greater risk of all-cause mortality, heart disease-related mortality, type 2 diabetes, depressive outcomes, adverse sleep outcomes, wheezing, and obesity.

The Call to Action: Implications for Public Health

This umbrella review is a significant contribution to the ongoing debate about ultra-processed foods and their impact on public health. Its findings are alarming, especially concerning the potential relationship between these foods and serious health risks such as heart disease, diabetes, and adverse mental health outcomes.

The research emphasizes the urgency for further detailed studies that could elucidate how these foods exert their harmful effects and calls for a public health response that targets the minimization of ultra-processed food consumption. It suggests a strong rationale for implementing and evaluating public health measures aimed at reducing these dietary risks. The hope is that by curbing the consumption of ultra-processed foods, we can improve the population's health on a broad scale.

Looking Ahead

While the study concludes there is considerable evidence indicating that ultra-processed foods could be a significant health hazard, quality ratings for much of this evidence weren't very high. This means that while a link exists, more refined research could provide firmer conclusions. Nevertheless, the findings are sufficiently concerning to merit attention from both policymakers and the public.


References

Melissa M Lane,Elizabeth Gamage, Shutong Du, Deborah N Ashtree, Amelia J McGuinness, Sarah Gauci, Phillip Baker, Mark Lawrence, Casey M Rebholz, Bernard Srour, Mathilde Touvier, Felice N Jacka, Adrienne O’Neil, Toby Segasby, Wolfgang Marx; Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-077310 (Published 28 February 2024)