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Breaking Myths: Study Reveals Vitamin D Supplements May Not Strengthen Bones for All

Written by Andrew Le, MD

UpdatedMarch 25, 2024

A significant medical journal recently published findings on whether vitamin D supplements can prevent bone fractures in adults. The research came from the Vitamin D and Omega-3 Trial (VITAL), a study examining the effects of vitamin D and omega-3 fatty acids on cancer and cardiovascular disease prevention. Here's what they found.

Background and Purpose of the Study:

For years, vitamin D has been commonly suggested to the general public as a way to keep bones healthy, but there has been debate and inconsistent data regarding its effectiveness in preventing fractures. VITAL looked into this by testing whether a daily supplement of vitamin D3 in a dose of 2000 International Units (IU) would decrease the occurrence of fractures compared to a placebo—a substance with no therapeutic effect, used as a control in testing new drugs.

Methods and Participants:

The study was not focused on individuals already at high risk for bone fractures, such as those with vitamin D deficiency or osteoporosis. Instead, it involved men aged 50 and above and women aged 55 and above from across the United States—a demographic representative of midlife and older adults. The participants reported any incidents of bone fractures annually, and these reports were carefully reviewed by healthcare professionals who confirmed the fractures.

Results:

With a diverse participant pool of 25,871 men and women—including around 20% Black individuals—the study found that over an average of 5.3 years, supplemental vitamin D3 did not significantly reduce the risk of all types of fractures. Specifically, the risk of nonvertebral fractures (those occurring outside the spine) and hip fractures showed no significant difference between the vitamin D group and the placebo group. The results were consistent across different ages, genders, races, body weights, and initial blood vitamin D levels.

Conclusion:

Ultimately, the study concluded that taking vitamin D3 supplements does not significantly lower the risk of fractures in generally healthy middle-aged and older adults who are not already identified as having a higher risk of fractures due to factors like vitamin D deficiency or osteoporosis. This challenges the previous belief in the broad effectiveness of vitamin D supplements for bone health in the general adult population.


References

LeBoff MS, Meryl S, Ratliff KA, Cook NR, Khurana B, Kim E, et al. Supplemental vitamin D and incident fractures in midlife and older adults. N Engl J Med. 2022; 387(4): 299–309. https://doi.org/10.1056/NEJMoa2202106