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Top 10 Best Vitamin K2 Supplements for Bone and Heart Health

Best Vitamin K2 Supplement
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Written by Andrew Le, MD.
Medically reviewed by
Clinical Physician Assistant, Summit Health
Last updated May 25, 2024

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Ensuring strong bone health and a well-functioning cardiovascular system is essential for maintaining overall wellness, yet numerous individuals encounter challenges achieving optimal levels of essential nutrients like vitamin K2.

Deficiencies in vitamin K2 can lead to various health issues, including osteoporosis, increased risk of fractures, and calcification of blood vessels, which can contribute to heart disease. These potential consequences highlight the importance of ensuring adequate vitamin K2 intake.

Fortunately, many high-quality vitamin K2 supplements are available to address these concerns. Incorporating the right vitamin K2 supplement into your daily routine can support strong bones, promote cardiovascular health, and safeguard your overall well-being.

The top 10 vitamin K2 supplements reviewed in this article offer effective solutions to enhance calcium metabolism, improve bone density, and maintain arterial flexibility, providing the necessary tools to prioritize your bone and heart health.

The Role of Vitamin K2 in Bone Health

Vitamin K2 plays a pivotal role in maintaining bone health, primarily through its ability to activate proteins that regulate bone formation. One of the most crucial proteins influenced by Vitamin K2 is osteocalcin, which helps bind calcium to the bone matrix, thus strengthening the bones. This action highlights Vitamin K2's essential role in bone growth and the maintenance and repair of bones. Previous research has shown how Vitamin K2, particularly MK-7, enhances bone quality by influencing these critical biological pathways.

The benefits of Vitamin K2 on bone health are well-documented in various clinical settings. For example, one study highlights the effectiveness of Vitamin K2 in improving bone health among different demographics, including postmenopausal women, who are typically at higher risk for osteoporosis. This study underscores the potential of Vitamin K2 supplementation to enhance bone mineral density and significantly reduce fracture risks.

Additionally, research on transplant recipients, who often experience accelerated bone breakdown, has shown that Vitamin K2 supplementation can help maintain bone mass and prevent fractures. This is particularly evident in the findings from a study focused on lung and heart transplant recipients, showing positive outcomes in bone density measurements post-supplementation.

The Role of Vitamin K2 in Cardiovascular Health

Vitamin K2 is also crucial for cardiovascular health, mainly because it can prevent the calcification of blood vessels. Calcification poses a risk for cardiovascular conditions by potentially reducing the flexibility of arteries and raising their rigidity.

Vitamin K2 works by activating matrix GLA protein, which prevents calcium from depositing in the vessel walls, thereby preserving arterial flexibility and promoting overall cardiovascular health. Previous research has discussed how Vitamin K2 reduces vascular calcification, potentially reducing the incidence of cardiovascular diseases and mortality related to heart conditions.

Numerous studies have supported the long-term benefits of Vitamin K2 on heart health. One such study emphasizes the synergistic effects of Vitamin K2 and calcium, noting that proper intake of these nutrients not only improves bone health but also aids in reducing cardiovascular risks.

Best Vitamin K2 Supplements for Bone and Heart Health

We have researched the Top 10 Best Vitamin K2 Supplements for Bone and Heart Health and selected them based on their effectiveness, ingredient quality, and positive customer feedback. These supplements are renowned for enhancing calcium metabolism, thus improving bone density and cardiovascular health.

OptiWell

Live Conscious Vitamin K2 MK7 with D3 Supplement offers a comprehensive solution for supporting bone and heart health. Recognized as one of the best options for enhancing overall well-being, this product combines the benefits of patented Vitamin K and Vitamin D3 to provide essential support for the body's vital systems.

Pros

  • The combination of Vitamin K2 and D3 strengthens the immune system, helping to defend against foreign threats and maintain overall health.
  • Vitamin K2 ensures proper calcium distribution in the body, promoting cleaner circulation and reducing the risk of calcification in arteries.
  • By preventing arterial calcification, this supplement supports heart health and contributes to maintaining overall cardiovascular well-being.
  • The supplement comes in easy-to-swallow softgel form, making it convenient to incorporate into daily routines.

Cons

  • While rare, some individual may experience mild side effects like headaches or grogginess.
Sports Research Vitamin K2

Sports Research Vitamin K2 MK7 with Coconut Oil offers robust bone and cardiovascular health support. This supplement stands out as a preferred option for those aiming to boost bone density and support cardiovascular health. Distinguished from numerous alternatives available, this product utilizes the potency of Vitamin K2 to efficiently carry calcium from the bloodstream to the bones, thereby strengthening bone density and supporting cardiovascular function.

With each soft gel encapsulated in coconut MCT oil, users benefit from enhanced absorption and the pleasant citrus aroma of a ScentCert Desiccant insert. Moreover, Sports Research ensures the highest quality by sourcing Vitamin K2 from fermented chickpeas and excluding unwanted additives like gluten, soy, and carrageenan.

Pros

  • Utilizes Vitamin K2 to support bone health and cardiovascular function effectively.
  • Softgel format encapsulated in coconut MCT oil enhances absorption and provides a pleasant citrus aroma.
  • It is sourced from fermented chickpeas, making it suitable for individuals with soy allergies.
  • Free from unwanted additives such as gluten, soy, and carrageenan, ensuring purity and safety.
  • Every batch undergoes meticulous third-party testing to ensure quality, and production takes place in cGMP-compliant facilities in the USA.

Cons

  • It may require higher dosages (multiple soft gels) for individuals with specific health needs.
  • Some users may find the chickpea-based enzyme less potent than alternatives like nattokinase.
  • Limited availability in larger bottle sizes or higher dosage concentrations.
MaryRuth Organics Vitamin D3 K2 Liquid Spray
  • MaryRuth Organics Vitamin D3 K2 Liquid Spray is a top-tier supplement designed to bolster bone and heart health, setting a high standard in the realm of vitamin K2 supplements. Crafted with precision and care, this product has an exceptional quality and efficacy.

Pros

  • MaryRuth Organics has upgraded its formula to USDA Organic standards, ensuring the highest quality ingredients for maximum effectiveness.
  • With a strong blend of Vitamin D3 and Vitamin K2 (MK-7), this spray promotes calcium absorption and supports heart health, addressing two critical aspects of overall well-being.
  • This spray offers a convenient, hassle-free way to incorporate essential vitamins into your daily routine. Simply shake well and administer directly into the mouth, eliminating the need for swallowing large tablets.
  • The spray format allows for precise dosage adjustments based on age and individual needs, catering to infants, children, adults, and pregnant or lactating individuals.
  • MaryRuth Organics remains committed to sustainability and inclusivity, offering a vegan, non-GMO, dairy-free, nut-free, gluten-free, soy-free, and sugar-free formulation that aligns with diverse dietary preferences and restrictions.

Cons

  • While the spray format enhances convenience, some users may find the taste reminiscent of olive oil, which could be off-putting to those sensitive to its flavor or texture.
  • Despite its numerous benefits, individuals with heightened taste sensitivity may find it challenging to mask the flavor of the spray, potentially impacting overall user experience.
Zhou Nutrition Vitamin D3 K2

Zhou Nutrition Vitamin D3 K2 is designed to support bone and heart health while providing immune support. With 5000 IU of Vitamin D3 and 90 mcg of Vitamin K2 (as MK-7), this formula is tailored to maximize the benefits of both essential nutrients.

This product is especially noteworthy for promoting calcium absorption and directing it to the bones. It plays a critical role in preserving bone density and lowering the likelihood of arterial calcification. Combining Vitamin D3 and K2 ensures that calcium is utilized efficiently, supporting a healthy heart and cardiovascular system.

Pros

  • Including Vitamin K2 as MK-7 enhances bioavailability, ensuring optimal absorption and utilization of calcium.
  • It supports bone health by directing calcium to bones, which may help prevent osteoporosis and maintain bone density.
  • It aids in sustaining cardiovascular health by averting calcium accumulation in arteries, thus mitigating the risk of calcification.
  • It is manufactured in a facility following Good Manufacturing Practices (GMP), ensuring quality and purity.
  • Suitable for vegetarians, with easy-to-swallow veggie capsules.

Cons

  • For some users, especially those with difficulty swallowing pills, the size of the capsules may pose a challenge.
  • It is unsuitable for individuals allergic to soy or other ingredients listed in the product.
  • It may not be suitable for individuals with certain medical conditions or those taking specific medications without consulting a healthcare professional.
InnovixLabs Full Spectrum Vitamin K2

InnovixLabs Full Spectrum Vitamin K2 MK-7-90 Capsules offer a comprehensive solution for promoting bone and heart health. With a balanced combination of essential vitamins K2, MK-4, and MK-7, this supplement stands out as a premier choice for individuals seeking to support their general well-being.

Designed to facilitate healthy bones, arteries, and brain function, it emphasizes the importance of directing calcium transport into bones rather than soft tissues, a crucial aspect for maintaining optimal health. The easily absorbed bioactive trans forms of vitamin K2, MK7, and MK4 ensure maximum user benefits, promoting efficient utilization within the body.

Pros

  • InnovixLabs Full Spectrum Vitamin K2 MK-7-90 Capsules provide a comprehensive spectrum of vitamin K2, including MK-4 and MK-7 forms, ensuring users receive balanced and practical bone and heart health support.
  • With bioactive trans forms of vitamin K2 MK7 and MK4, this supplement offers superior absorption, allowing for maximum utilization by the body and thereby optimizing the benefits for the user.
  • Including potent MK-4 vitamin K2 supports normal cognitive health, benefiting brain function and potentially aiding in developing a developing fetus.
  • Each batch of InnovixLabs Full Spectrum Vitamin K2 MK-7-90 Capsules undergoes rigorous third-party testing for purity, potency, and freshness, ensuring a high-quality product that users can trust.
  • Backed by exceptional customer service, InnovixLabs prioritizes the health and satisfaction of its customers, offering an allergen-friendly, easy-to-swallow, plant-based K-2 vitamin that aligns with various dietary preferences and requirements.

Cons

  • This product does not contain Vitamin K1, which may be desirable for some users. However, its absence is intentional due to potential interference with blood-thinning medications, emphasizing the need for users to consider their health circumstances.
  • While users may experience the benefits of vitamin K2 supplementation over time, the effects may not be immediately noticeable, requiring consistent usage for optimal results.
  • Some users may experience mild side effects or sensitivities to vitamin K2 supplementation, although these occurrences are rare and may vary depending on individual factors.
Life Extension Super K

Life Extension Super K is the ultimate solution for maintaining optimal bone and heart health. With its potent blend of vitamin K1, vitamin K2 mk-7, vitamin K2 mk-4, and vitamin C, this supplement provides a holistic approach to supporting your body's calcium balance, which is crucial for bone density and arterial health. Designed to provide a 3-month supply in each pack, Life Extension Super K is gluten-free, non-GMO, and offers 90 soft gels per container.

Pros

  • Super K combines multiple forms of vitamin K, including K1, MK-4, and MK-7, to ensure maximum effectiveness in promoting bone and heart health.
  • With a potent dose of 2600 mcg of vitamin K per serving, this supplement provides a strong solution for individuals looking to maintain their calcium balance.
  • Including MK-4 and MK-7 ensures rapid absorption and sustained availability in the body, offering the benefits of both forms of vitamin K.
  • Life Extension prides itself on sourcing only the finest raw ingredients, ensuring purity, potency, and effectiveness.
  • With over 40 years of experience developing advanced nutritional formulas based on scientific research, Life Extension is a reputable and trusted brand in the supplement industry.

Cons

  • Some users may find the size of the soft gels to be larger than preferred, which can make them difficult to swallow for some individuals.
Jarrow Formulas MK-7

Jarrow Formulas MK-7 offers a potent solution for promoting bone and heart health, encapsulated in each soft gel. This product is premier for those seeking the best vitamin K2 supplements.

Jarrow's MK-7 provides an active form of vitamin K2, which is essential for cardiovascular health and bone strength. Each soft gel delivers 90 mcg of vitamin K2, supporting the carboxylation of specific proteins crucial for bone building and cardiovascular well-being.

Pros

  • Jarrow Formulas upholds high-quality standards, ensuring purity and efficacy in each soft gel.
  • With 90 mcg of vitamin K2 per soft gel, it provides an optimal dosage for promoting bone density and cardiovascular health.
  • The natural MK-7 form of vitamin K2 offers superior absorption to K1, making it highly bioavailable.
  • It is free from gluten, wheat, soy, dairy, egg, fish, shellfish, peanut, tree nut, and sesame, catering to various dietary restrictions.
  • Qualified healthcare professionals recommend it for daily supplementation to support bone health and cardiovascular function.

Cons

  • Some users may prefer alternative forms of supplementation, such as capsules or tablets, over soft gels.
  • Although rare, a few users have reported mild side effects like heart palpitations or issues with adhesion.
Solgar Vitamin K2

Solgar's Vitamin K2 MK7 100mcg Vegetable Capsules are the epitome of excellence in supporting bone and heart health. This supplement stands out as the premier choice for those seeking the finest Vitamin K2 supplementation, derived from a natural whole food source extracted from Natto. Solgar's commitment to quality ensures that each capsule delivers the utmost purity and potency, making it an indispensable addition to any wellness routine.

Pros

  • Derived from Natto extract, Solgar's Vitamin K2 offers a naturally sourced form of the vitamin, providing maximum effectiveness for bone and heart health support.
  • Vitamin K2 is crucial in promoting bone health by properly utilizing calcium in the bones, helping maintain their strength and integrity.
  • Solgar's Vegetable Capsules are suitable for lacto-vegetarians and are certified gluten-free, ensuring compatibility with various dietary preferences and restrictions.
  • With over 70 years of dedication to quality, Solgar upholds stringent manufacturing standards, guaranteeing the finest nutritional supplements for consumers.

Cons

  • Some users have reported experiencing stomach pains and headaches after taking the supplement, though these occurrences are relatively rare.
  • While Solgar's Vitamin K2 offers numerous benefits for bone and heart health, its effectiveness may require consistent, long-term use to yield noticeable results.
NOW Supplements Vitamin K2

NOW Supplements Vitamin K2 (MK-7) 300mcg Extra Strength stands out as a choice for individuals seeking top-notch bone and heart health support. This extra-strength formula offers three times the vitamin K-2 compared to regular strength products, ensuring maximum effectiveness.

Pros

  • With 300mcg of Vitamin K2 per capsule, this supplement provides an extra strength dose to effectively support bone and heart health.
  • Vitamin K2 plays a crucial role in synthesizing blood coagulation factors and is essential for maintaining strong, healthy bones.
  • MenaQ7® MK-7, the unique form of vitamin K-2 used in this supplement, supports arterial health by aiding proper calcium metabolism in blood vessels and arteries.
  • These capsules suit vegetarians, offering a convenient way to support bone and heart health without compromising dietary preferences.
  • Produced in a GMP facility, this supplement undergoes rigorous testing to ensure purity, potency, and safety.

Cons

  • While generally well-tolerated, some users may experience mild side effects such as headaches or gastrointestinal discomfort.
  • Users requiring higher doses of Vitamin K2 may need to take multiple capsules, leading to increased cost per serving for some individuals.
Doctor's Best Natural Vitamin K2

Doctor's Best Natural Vitamin K2 Mk-7 Capsules are crafted to support both bone health and soft tissue elasticity, making it an ideal choice for those seeking comprehensive wellness benefits. With a dedication to purity and quality, Doctor's Best has formulated a product that stands out as a superior option for vitamin K2 supplements.

Harnessing the power of Vitamin K2, Doctor's Best offers a unique blend that is absorbed more completely by the body and remains effective for longer periods. This particular product contains pure MENAQ7, sourced from fermented chickpeas, ensuring the highest bioavailability of Vitamin K2 to support strong bones and overall health.

Pros

  • Doctor's Best is a trusted brand known for its commitment to purity and quality, ensuring that each capsule meets rigorous standards.
  • With 100mcg of Vitamin K2 Mk-7 per serving, it provides an optimal dosage for supporting bone health and soft tissue elasticity.
  • The inclusion of MENAQ7, purified from fermented chickpeas, offers the most bioavailable form of Vitamin K2 for maximum effectiveness.
  • Vitamin K2 Mk-7 supports calcium absorption, helping to maintain healthy blood vessels and direct calcium to the bones, thus contributing to overall bone health.
  • This supplement is appropriate for various dietary preferences, being both vegan and GMO-free, as well as free from gluten and soy.

Cons

  • Some users may prefer alternative forms of supplements, such as liquid or soft gel options, which are not available with this product.
  • While rare, some users may experience mild side effects such as headaches or gastrointestinal discomfort, although these instances are infrequent.

Final Thoughts

Out of the top 10 vitamin K2 supplements reviewed, Sports Research Vitamin K2 MK7 with Coconut Oil is an exceptional choice for those seeking optimal bone and cardiovascular health support. This supplement harnesses the power of vitamin K2 to effectively transport calcium from the bloodstream to the bones, thereby strengthening bone density and promoting cardiovascular function.

What sets Sports Research Vitamin K2 apart is its meticulous formulation. Encapsulated in coconut MCT oil, each soft gel offers enhanced absorption and a pleasant citrus aroma. Furthermore, the brand ensures purity by sourcing vitamin K2 from fermented chickpeas and excluding unwanted additives like gluten, soy, and carrageenan. With rigorous third-party testing and manufacturing in cGMP-compliant facilities, you can trust in the quality and effectiveness of this product.

FAQs on the Best Vitamin K2 Supplements for Bone and Heart Health

What is Vitamin K2, and how does it differ from Vitamin K1?

Vitamin K1 (phylloquinone) is primarily found in leafy green vegetables and is essential for blood clotting. Vitamin K2 (menaquinone) occurs in fermented foods and animal products and is crucial for bone and heart health by helping to direct calcium to the bones and away from the arteries.

What is the recommended daily intake of Vitamin K2?

The general recommendation is 90-120 micrograms per day, depending on factors like age and gender. For specific heart and bone health benefits, doses in studies typically range from 100 to 200 mcg per day​.

What foods are rich in Vitamin K2?

Vitamin K2 is found in fermented foods such as miso, cheese, natto, and tempeh. Animal products like dark chicken meat and egg yolks also contain Vitamin K2​.

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Clinical Physician Assistant, Summit Health
Jeff brings to Buoy 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medicine....
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