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Pulmonary Hypertension

Pulmonary hypertension is when there is high blood pressure in the blood vessels in your lungs. It can cause shortness of breath when you’re active and fatigue.
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Medically reviewed by
Last updated February 13, 2022

Pulmonary hypertension quiz

Take a quiz to find out if you have pulmonary hypertension.

What is pulmonary hypertension?

Pulmonary hypertension (PH) is when there is high blood pressure in the blood vessels going from the heart to the lungs. This is a different disease from hypertension (high blood pressure), which affects your whole body.

Pulmonary hypertension leads to low oxygen in your body. It can cause shortness of breath and fatigue.

High blood pressure in the lungs can be caused by a range of diseases and conditions. They include problems with the heart pumping blood, blood clots, low oxygen in the lungs (which causes blood vessels to constrict), or from thickening of the arteries (called pulmonary arterial hypertension or PAH).

It can get worse over time. However, if you can diagnose its underlying cause and treat it, then symptoms can improve, or even disappear.

Most common PH symptoms

Pro Tip

"Pulmonary hypertension can cause shortness of breath with exertion, fainting, low oxygen levels, and/or lower extremity swelling. I listen for patients telling me they are having trouble doing things they used to be able to do because they are now short of breath. For example, patients now having trouble walking to the store or going upstairs." — Dr. Benjamin Ranard

Low oxygen levels in the blood cause general fatigue and shortness of breath when you’re physically active. It can also lead to lightheadedness and fainting.

When the heart isn’t receiving enough oxygen, you may feel pain in the chest.

Pulmonary hypertension increases pressure in the blood vessels between the heart and the lungs. Over time, this stresses the heart, making it harder for the heart to pump. It may lead to other symptoms, such as fluid build-up in the legs and belly and a lack of appetite.

Main symptoms

  • Shortness of breath; difficulty breathing. At first, you may notice it during physical activity, such as running. But it may start to happen when walking around the house or even at rest.
  • Fatigue

As it progresses, symptoms can include:

  • Lightheadedness or fainting, especially with activity
  • Chest pain with physical activity
  • Swelling in the legs and belly
  • Weight gain (from the fluid build-up)
  • Loss of appetite

Risk factors for pulmonary hypertension

A range of conditions, each with their own risk factors, can cause pulmonary hypertension. But these are some common risk factors.

  • Family history of pulmonary arterial hypertension (PAH)
  • Obesity combined with obstructive sleep apnea
  • Female
  • Pregnancy
  • Living at a high altitude for years can increase your risk
  • Having other diseases, including congenital heart disease, lung disease, liver disease, scleroderma, and lupus
  • Certain drugs, such as methamphetamines

How serious is pulmonary hypertension?

Pro Tip

"In the past 20 years there have been over 10 new FDA approved medications for pulmonary arterial hypertension. There are many ongoing trials studying both new drugs and also studying different combinations of drugs to determine what the best treatment options are for patients." — Dr. Ranard

If you have new or sudden shortness of breath or chest pain, go to the ER. It could be a sign of something more serious.

If you have been experiencing shortness of breath or difficulty breathing during physical activity for a few weeks or months, see your doctor.

The symptoms of pulmonary hypertension (especially fatigue and feeling lightheaded) can seem vague and may be caused by other problems. It is important to see your doctor.

What is the main cause of pulmonary hypertension?

Pulmonary hypertension is a form of high blood pressure in the vessels that connect the heart to the lungs. There are many reasons that it may develop.

  • Left heart disease. This is the most common cause of pulmonary hypertension in the United States. Blood travels from the right side of the heart to the lungs and out to the left side of the heart and then to the body. Problems with the left heart such as a weak squeeze can cause blood to back up, leading to high blood pressure in the lungs.
  • PAH (thickening of the vessels). Blood pressure rises as blood tries to move through the narrowed vessels.
  • Lung disease and low oxygen
  • Blockage of the pulmonary (lung) artery

Dr. Rx

"If you are prescribed oxygen or breathing machines to use all the time, use the oxygen as much as possible. Sometimes patients stop using oxygen because they don’t think they need it. You may feel fine without the oxygen. However, even if not symptomatic, low oxygen levels in the blood can be bad for your heart and make pulmonary hypertension worse." —Dr. Ranard

What is the best treatment for pulmonary hypertension?

How pulmonary hypertension is treated depends on the cause. Whether it’s an underlying heart disease, lung disease, low oxygen, blood clots, or bodywide diseases. For instance, if it’s from blood clots, a blood thinner may be recommended. If you have sleep apnea, that would be addressed.

The one condition that is treated directly with specific medications is PAH. They include calcium channel blockers, endothelin receptor antagonists, prostacyclin pathway agonists and nitric oxide enhancers. are a group of medications that dilate blood vessels. The medications may be pills, inhaled, or intravenous.

Pulmonary hypertension may go away if the underlying cause can be treated. For example, if the cause is weak pumping of the left side of the heart (called heart failure), treating that can improve pulmonary hypertension.

Many causes of pulmonary hypertension are chronic conditions that require long-term care. If you have severe pulmonary hypertension or it is not easily reversible by treating the underlying issue, follow up with a cardiologist (heart specialist) or pulmonologist (lung specialist).

Ready to treat your pulmonary hypertension?

We show you only the best treatments for your condition and symptoms—all vetted by our medical team. And when you’re not sure what’s wrong, Buoy can guide you in the right direction.See all treatment options
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The stories shared below are not written by Buoy employees. Buoy does not endorse any of the information in these stories. Whenever you have questions or concerns about a medical condition, you should always contact your doctor or a healthcare provider.
Dr. Le obtained his MD from Harvard Medical School and his BA from Harvard College. Before Buoy, his research focused on glioblastoma, a deadly form of brain cancer. Outside of work, Dr. Le enjoys cooking and struggling to run up-and-down the floor in an adult basketball league.

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