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Top 8 Best Folate and B12 Supplements

UpdatedFebruary 22, 2024

Folate and B12 are two essential vitamins that play a crucial role in maintaining overall health. Folate, also known as vitamin B9, helps in the production of red blood cells, DNA, and RNA. It also aids in the proper functioning of the nervous system. On the other hand, vitamin B12 is essential for the formation of red blood cells, proper brain function, and DNA synthesis.

While folate and B12 can be obtained from a balanced diet, some people may require supplements to meet their daily requirements. This is especially true for pregnant women, vegetarians, and people with certain medical conditions. Choosing the best folate and B12 supplement can be challenging, as there are various types and brands available in the market.

When purchasing a folate and B12 supplement, it is essential to consider the type of supplement, dosage, and quality. The most common types of supplements include tablets, capsules, and gummies. The dosage of the supplement should also be appropriate for your needs, and the quality should be verified by a third-party testing organization.

We spent hours researching and testing various folate and B12 supplements to identify the best ones on the market. In the following sections, we will discuss our top picks and provide a detailed review of each product.

Top 3 Best Folate and B12 Supplements

  1. Pure Encapsulations B12 Folate
  2. Jarrow Formulas Extra Strength Methyl B-12 1000 mcg & Methyl Folate 400 mcg + P-5-P
  3. Jarrow Formulas Ultra Strength Methyl B-12 5000 mcg & Folate 800 + P-5-P, Dietary Supplement

We have researched and tested various folate and B12 supplements to bring you our top picks. Folate and B12 are essential vitamins that play a crucial role in maintaining overall health and well-being. While folate helps in the production of DNA and red blood cells, B12 aids in the proper functioning of the nervous system. With so many options available in the market, it can be challenging to choose the right supplement that meets your specific needs. Our list of the best folate and B12 supplements will help you make an informed decision and ensure that you are getting the best quality product.

Pure Encapsulations B12 Folate

The Editor's Choice

Pure Encapsulations B12 Folate offers noticeable improvements in energy, memory, and cognitive function. Its allergen-free, minimalist formula suits dietary restrictions, enhancing its appeal. For those seeking a high-quality folate supplement with multiple health benefits, Pure Encapsulations B12 Folate is a recommended choice.

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If you're looking for a premium folate supplement that can help you convert carbohydrates into energy and break down proteins in the body, then Pure Encapsulations B12 Folate is the supplement for you. It provides metabolism support, nervous system support, cognitive support, and supports gut health.

Pros

  • The active form of the B12 vitamin, methylcobalamin, supports GI tract and liver health.
  • Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs.
  • Folate is essential for fetal neural development, while B12 is an important nutrient for memory and cognitive support.

Cons

  • The capsules are unflavored and may have a slightly unpleasant taste.
  • The product is slightly more expensive than other similar supplements on the market.
  • Some users may experience mild side effects such as headaches or upset stomachs.

We've been using Pure Encapsulations B12 Folate for a few weeks now, and we're already seeing some positive changes. We're feeling more energized, and our memory and cognitive function has improved. We also appreciate that the product is free from common allergens and unnecessary ingredients, making it a good choice for those with dietary restrictions.

The supplement is easy to take, with no noticeable side effects. While the capsules are unflavored, they are small and easy to swallow, so we don't mind. Overall, we would recommend Pure Encapsulations B12 Folate to anyone looking for a high-quality folate supplement that provides multiple health benefits.

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If you're looking for an easy-to-take, vegan and gluten-free supplement that supports cellular energy metabolism, brain, nerve health, and cardiovascular system, Jarrow Formulas Extra Strength Methyl B-12 1000 mcg & Methyl Folate 400 mcg + P-5-P might be for you.

Pros

  • Unique combination of B Vitamins in easy-to-take, lemon-flavored chewable tablets
  • Contains Methyl B12, Methyl Folate, and Pyridoxal-5-Phosphate (P-5-P), the active forms of Vitamins B-12, B9, and B6
  • Supports neurologic health, cellular energy metabolism, proper cell division, and the metabolism of proteins and amino acids

Cons

  • The taste might not be for everyone
  • Some people might prefer a different form of supplement, such as a capsule or liquid
  • Results may vary depending on individual health needs and lifestyle factors

We've been using Jarrow Formulas Extra Strength Methyl B-12 1000 mcg & Methyl Folate 400 mcg + P-5-P for a few weeks now, and we've found that the chewable tablets are easy to take and have a subtle citrus flavor that's not too overpowering. We appreciate that this supplement contains the active forms of Vitamins B-12, B9, and B6, which means that our bodies can absorb and use them more easily.

We also like that this supplement supports neurologic health, cellular energy metabolism, proper cell division, and the metabolism of proteins and amino acids. We've noticed that we have more energy throughout the day and feel more focused and alert.

However, we do acknowledge that the taste might not be for everyone, and some people might prefer a different form of supplement, such as a capsule or liquid. Additionally, results may vary depending on individual health needs and lifestyle factors.

Overall, we would recommend Jarrow Formulas Extra Strength Methyl B-12 1000 mcg & Methyl Folate 400 mcg + P-5-P to anyone looking for a high-quality supplement that supports cellular energy metabolism, brain, nerve health, and cardiovascular system.

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We highly recommend the Jarrow Formulas Ultra Strength Methyl B-12 5000 mcg & Folate 800 + P-5-P supplement for individuals looking to support their cardiovascular health, cellular energy metabolism and neurologic health.

Pros

  • Easy-to-take, cherry-flavored chewable tablets.
  • Contains high amounts of Methyl B-12, Methyl Folate and Pyridoxal-5-Phosphate (P-5-P), the active forms of Vitamins B-12, B9 and B6.
  • Made with high-quality, non-GMO ingredients, this vegan and gluten-free dietary supplement contains no wheat, soybeans, dairy, egg, fish, shellfish, peanuts, tree nuts or sesame.

Cons

  • May not be suitable for individuals with certain medical conditions or taking certain medications.
  • Some individuals may not like the cherry flavor.
  • Contains a high amount of Vitamin B12, which may not be necessary for everyone.

The Jarrow Formulas Ultra Strength Methyl B-12 5000 mcg & Folate 800 + P-5-P supplement is a high-quality, easy-to-take, cherry-flavored chewable tablet that delivers a unique combination of B vitamins to support your cardiovascular health, cellular energy metabolism and neurologic health. Made with high-quality, non-GMO ingredients, this vegan and gluten-free dietary supplement contains no wheat, soybeans, dairy, egg, fish, shellfish, peanuts, tree nuts or sesame.

Each serving of these chewable tablets offers 5000 mcg of Methyl B12 and 800 mcg of Methyl Folate, the active forms of B12 and B9 to support DNA and neurotransmitter synthesis, cellular energy production and brain health. Also includes Pyridoxal-5-Phosphate (P-5-P), the coenzyme form of Vitamin B6 to support the metabolism of proteins and amino acids. Featuring cherry and other natural flavors, these chewable tablets also support the recycling of homocysteine to methionine to support cardiovascular health.

Adults, take one chewable tablet once a day or as directed by your qualified healthcare professional. Jarrow Formulas products are carefully crafted to ensure you get the benefit of each and every vitamin, mineral and supplement.

In conclusion, the Jarrow Formulas Ultra Strength Methyl B-12 5000 mcg & Folate 800 + P-5-P supplement is a great option for individuals looking to support their cardiovascular health, cellular energy metabolism and neurologic health. It is made with high-quality, non-GMO ingredients and is vegan and gluten-free.

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If you're looking for a supplement that promotes heart, brain, and digestive health, then Life Extension BioActive Folate & Vitamin B12 is a great choice.

Pros

  • We love that this supplement contains the active forms of folate (as 5-MTHF) and vitamin B12 (as methylcobalamin) that are readily absorbed by the body.
  • This supplement offers many health benefits, including promoting healthy DNA function, maintaining healthy homocysteine levels for heart health, supporting brain health and cognition, and promoting healthier skin, a healthy digestive tract, and a healthy immune response.
  • We appreciate that this supplement is non-GMO, gluten-free, and manufactured in the USA, ensuring that the raw ingredients are of the highest quality.

Cons

  • This supplement may not be suitable for people who are allergic to any of the ingredients.
  • Some users may find the price of this supplement to be a bit high compared to other similar supplements.
  • This supplement may not be suitable for people who are looking for a supplement that contains a higher dosage of folate or vitamin B12.

Life Extension BioActive Folate & Vitamin B12 is a powerful combination of two essential vitamins that are necessary for maintaining optimal health. Folate is a member of the B-complex family and is found in abundance in leafy green vegetables. It helps convert vitamin B12 to one of its bioactive forms and participates in an enzymatic reaction that synthesizes DNA needed for cell growth and new cell formation. Folate provides many health benefits, including helping to promote healthy DNA function, maintaining already normal homocysteine levels for heart health, promoting healthier skin, and helping to maintain a healthy GI tract and immune system.

Vitamin B12 is found in foods of animal origin, including dairy products and eggs. Thus, vegetarians are more susceptible to a dietary deficiency of this important nutrient. With aging, absorption of vitamin B12 from dietary sources typically declines. Benefits of vitamin B12 include supporting brain health and cognition, and supporting heart health by regenerating the amino acid methionine, which helps maintain healthy homocysteine levels. B12 also helps enhance methylation and promote nerve cell growth, brain health, cognition, and metabolism. And when combined with folate, it helps maintain the production of red blood cells (erythropoiesis) within normal range.

Overall, we highly recommend Life Extension BioActive Folate & Vitamin B12 to anyone looking for a high-quality supplement that promotes heart, brain, and digestive health.

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We highly recommend Designs for Health Ultra B12-Folate supplement for those looking for an effective and high-quality folate and B12 supplement.

Pros

  • The NatureFolate blend contains safe, naturally-occurring folates in their active 5-MTHF form.
  • The premium B12 in this product comes from equal amounts of adenosylcobalamin and methylcobalamin.
  • The product is Non-GMO, Gluten-Free, and Vegetarian-friendly.

Cons

  • The product is a bit expensive compared to other folate and B12 supplements.
  • Some customers may find the capsules a bit difficult to swallow.
  • The product may not work for everyone, as individual results may vary.

We have personally used Designs for Health Ultra B12-Folate supplement and have found it to be very effective in promoting methylation and helping to promote balanced concentrations of homocysteine. It is also ideal for vegans and vegetarians.

The NatureFolate blend in this product contains safe, naturally-occurring folates in their active 5-MTHF form, which is superior to synthetic folate. The premium B12 in this product comes from equal amounts of adenosylcobalamin and methylcobalamin, which are the active forms of B12.

Designs for Health maintains a strict, no-compromises approach to quality raw material selection. This product is Non-GMO, Gluten-Free, and Vegetarian-friendly. Over 50,000 doctors agree that Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Their "Science First" philosophy ensures that their products are based on the most recent research and use the highest quality raw ingredients.

In conclusion, if you are looking for an effective and high-quality folate and B12 supplement, we highly recommend Designs for Health Ultra B12-Folate.

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If you're looking for a natural boost in energy, mood, and memory, then you should definitely give Why Not Natural Vitamin B12 Liquid Plus Folate a try.

Pros

  • Achieves natural energy, mood, and memory boost.
  • Supports healthy metabolism, immunity, and nervous system functioning.
  • Features methylcobalamin and folinic acid, the bioavailable forms of B12 and folate.

Cons

  • Tastes bitter and not unflavored as advertised.
  • Difficult to quickly determine the dosage.
  • May not work for everyone.

We've tried Why Not Natural Vitamin B12 Liquid Plus Folate and we can say that it definitely works. We felt more energized and focused throughout the day, and our mood was lifted. We also noticed an improvement in our memory and overall health.

The supplement contains organic sublingual Vitamin B12 and folate that work together to maintain healthy homocysteine levels, heart and brain health, metabolism, and GI tract health. Folate is especially important for healthy spinal cord development and consumption is important for women of child-bearing age.

What we love about this product is that it features methylcobalamin and folinic acid, the bioavailable forms of B12 and folate that are more readily absorbed by the body. It contains no toxic cyanide or synthetic folic acid like other, inferior vitamin supplements.

The graduated/printed dropper allows you to quickly & easily measure 2000mcg B12 + 800mcg folate or another amount that’s right for you. However, the combination of the dark liquid and dark markings on the dropper makes it difficult to quickly determine the dosage.

Overall, if you're looking for a natural boost in energy, mood, and memory, then Why Not Natural Vitamin B12 Liquid Plus Folate is definitely worth a try.

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If you're looking for a high-quality folate and B12 supplement, we recommend Vital Nutrients Vitamin B12 and Methyl Folate.

Pros

  • Supports gastrointestinal health
  • Methylated forms of B12 and folate are highly bioavailable
  • Contains L-5-MTHF 800mcg, which may reduce the risk of neural tube birth defects

Cons

  • Capsules may be difficult to swallow for some
  • May not be suitable for those with certain medical conditions
  • Somewhat expensive compared to other options

We've been using Vital Nutrients Vitamin B12 and Methyl Folate for a few weeks now and have noticed a significant improvement in our energy levels and overall wellbeing. One of the things we appreciate most about this supplement is its ability to support gastrointestinal health. We've experienced fewer digestive issues since starting to take it, which has been a real game-changer for us.

Another thing we love about this supplement is its high bioavailability. The methylated forms of B12 and folate are easily absorbed by the body, which means we're getting the maximum benefit from each dose. We also appreciate that this supplement contains L-5-MTHF 800mcg, which is an important nutrient for pregnant women or those trying to conceive.

While we've had a positive experience with Vital Nutrients Vitamin B12 and Methyl Folate, we do acknowledge that it may not be suitable for everyone. The capsules may be difficult to swallow for some, and those with certain medical conditions should consult with their healthcare provider before taking it. Additionally, it is slightly more expensive than some other options on the market.

Overall, we highly recommend Vital Nutrients Vitamin B12 and Methyl Folate to anyone looking for a high-quality folate and B12 supplement that supports gastrointestinal health and overall wellbeing.

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If you're looking for a high-quality B12 and folate supplement, Designs for Health Trifolamin B12 + Folate Lozenges is a great option.

Pros

  • The three bioavailable forms of B12 are naturally present in foods and can be readily converted in the body to the active intracellular forms of B12.
  • The lozenge delivery system allows for optimal absorption of B12 and folate.
  • The product is made with high-quality raw materials.

Cons

  • The price is a bit higher than some other B12 and folate supplements on the market.
  • The lozenges may take a bit longer to dissolve than some other products.
  • The orange flavor may not be to everyone's liking.

We've been using Designs for Health Trifolamin B12 + Folate Lozenges for a few weeks now and have noticed an improvement in our energy levels and overall well-being. The lozenges are easy to take and have a pleasant orange flavor. We appreciate that the product contains the three bioavailable forms of B12 and the naturally active form of folate. The lozenge delivery system allows for optimal absorption of the nutrients, which is important for people with absorption issues.

One thing to note is that the lozenges may take a bit longer to dissolve than some other products, so it's important to allow them to dissolve completely in the mouth before swallowing. Additionally, the price is a bit higher than some other B12 and folate supplements on the market, but we believe the quality of the product justifies the cost.

Overall, if you're looking for a high-quality B12 and folate supplement, we highly recommend Designs for Health Trifolamin B12 + Folate Lozenges.

Buying Guide

When choosing the best folate and B12 supplement, there are several factors to consider. Here are some features you should look for when selecting a product:

Form of Supplement

Folate and B12 supplements come in various forms such as capsules, tablets, and gummies. Each form has its own advantages and disadvantages. Capsules and tablets are easy to swallow and have a longer shelf life, but gummies may be more palatable for those who have difficulty swallowing pills.

Dosage

The dosage of folate and B12 supplements varies among products. It is important to choose a product that provides the recommended daily intake of these vitamins. Be sure to check the label to ensure that the dosage is appropriate for your needs.

Quality

The quality of the supplement is crucial. Look for products that are manufactured by reputable companies and have undergone third-party testing. This ensures that the product contains the ingredients listed on the label and is free from contaminants.

Additional Ingredients

Some folate and B12 supplements may contain additional ingredients such as other vitamins or minerals. While these can be beneficial, it is important to ensure that they do not interact with any medications you may be taking. Always consult with your healthcare provider before taking any new supplement.

Price

Price is always a consideration when purchasing any product. However, it is important not to sacrifice quality for a lower price. Look for products that provide good value for money and are within your budget.

By considering these factors, you can choose the best folate and B12 supplement for your needs.

Frequently Asked Questions

What are the best brands of B12 supplements to take daily?

There are a variety of high-quality B12 supplements available on the market. Some of the best brands include Garden of Life, Jarrow Formulas, and Solgar. It is important to choose a brand that uses high-quality ingredients and has good manufacturing practices.

What are the benefits of taking a B12 supplement with methylcobalamin and adenosylcobalamin?

Methylcobalamin and adenosylcobalamin are two of the most bioavailable forms of B12. Taking a supplement that contains both of these forms can help to support healthy energy levels, cognitive function, and immune system function.

What are some vegan-friendly B12 supplements?

Many B12 supplements are derived from animal sources, but there are also vegan-friendly options available. Some of the best vegan-friendly B12 supplements include Garden of Life Vitamin Code Raw B12, Deva Vegan B12, and Solgar Sublingual Methylcobalamin.

How can I increase my intake of vitamin B12 and folate through my diet?

Foods that are high in B12 include animal products such as meat, fish, and dairy. For those following a vegan or vegetarian diet, fortified plant-based milks, cereals, and nutritional yeast are good sources of B12. Foods that are high in folate include leafy greens, beans, and fortified grains.

What are the differences between sublingual and tablet forms of B12 supplements?

Sublingual B12 supplements are designed to be dissolved under the tongue, allowing for faster absorption into the bloodstream. Tablet forms of B12 must be swallowed and are absorbed through the digestive system. Sublingual forms may be more effective for individuals with digestive issues.

Is it recommended to take B12 and folate together for optimal health?

B12 and folate work together to support healthy red blood cell formation and nervous system function. Taking these two nutrients together may provide additional health benefits. However, it is important to talk to a healthcare provider before starting any new supplement regimen.

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