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Top 8 Best Nattokinase Supplements for Cardiovascular Health

Best Nattokinase Supplement
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Written by Andrew Le, MD.
Medically reviewed by
Clinical Physician Assistant, Summit Health
Last updated May 25, 2024

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Cardiovascular health remains a major global concern as cardiovascular diseases (CVDs) are the leading cause of death worldwide. In 2019, CVDs accounted for approximately 17.9 million deaths globally, which represented about 31% of all global deaths during that year. This figure steadily increased from 14.2 million in 2000 to 15.9 million in 2010 to 17.9 million in 2019​.

While lifestyle changes such as regular exercise and a balanced diet can help, sometimes additional support is needed. Many people are turning to supplements to promote cardiovascular well-being, but with so many options available, it can be challenging to determine which products are most effective.

Fortunately, nattokinase supplements have emerged as a promising solution for supporting cardiovascular health. The top 8 nattokinase supplements featured in this article have been carefully selected based on their effectiveness, ingredient quality, safety profiles, and user reviews. By incorporating these supplements into your daily routine, you can take a proactive step towards maintaining a healthy heart and circulatory system.

Properties of Nattokinase

Nattokinase is a serine protease enzyme derived from "Natto," a traditional Japanese fermented soybean dish. It was discovered in the 1980s by Dr. Hiroyuki Sumi, who noted its potent fibrinolytic activity, which is the ability to dissolve blood clots. The enzyme is produced by the bacterium Bacillus subtilis during fermentation and has since garnered attention for its potential cardiovascular benefits.

The primary component of nattokinase is a fibrin-degrading enzyme that directly degrades fibrin and fibrinogen, which are essential factors in clot formation. This mechanism suggests that nattokinase could effectively prevent and treat conditions associated with thrombosis (blood clot formation) and related cardiovascular problems. Besides its fibrinolytic activity, nattokinase also exhibits abilities to inhibit platelet aggregation, which further contributes to its antithrombotic properties.

One of the significant aspects of nattokinase is its bioavailability when taken orally, which is not common among many proteolytic enzymes. This attribute makes nattokinase a practical supplement for daily consumption to support cardiovascular health. Moreover, its prolonged effects in the circulatory system allow for sustained activity against blood clots over time, enhancing its therapeutic potential.

Studies have also highlighted the enzyme's safety profile, indicating that it can be consumed with minimal risk of side effects, which is particularly important for long-term use in preventive health strategies. This safety and its efficacy position nattokinase as a promising supplement for cardiovascular health management.

Efficacy Of Nattokinase In Influencing Cardiovascular Health

A comprehensive systematic review and meta-analysis assessed the impact of nattokinase supplementation on cardiovascular risk factors across multiple randomized controlled trials. The study concluded that nattokinase supplementation significantly reduces blood pressure and other risk markers for cardiovascular diseases, suggesting a broad potential for cardiovascular health improvement.

Moreover, one study demonstrated that nattokinase supplementation significantly reduces systolic and diastolic blood pressure among subjects. The trial provided concrete evidence of nattokinase's antihypertensive properties, making it an attractive option for people with hypertension looking to manage their condition through natural means.

Best Nattokinase Supplements for Cardiovascular Health

We have researched the top nattokinase supplements and selected them based on their effectiveness, ingredient quality, safety profiles, and user reviews. These supplements are known for supporting cardiovascular health by promoting healthy blood circulation and reducing the risk of blood clots.

Doctor's Best Nattokinase

Doctor's Best Nattokinase stands out as a premier solution derived from natto. Through a meticulous process involving non-GMO soybeans and friendly Bacillus subtilis bacteria, nattokinase is produced, offering a pure enzyme with Vitamin K2 removed. This product is meticulously formulated to support a healthy circulatory system by assisting in maintaining normal fibrinogen levels in the blood, thus promoting normal blood flow.


  • Clinical and non-clinical studies have indicated that Nattokinase can contribute to heart and circulatory health by aiding in the maintenance of normal blood flow.
  • The vegan formula of Nattokinase promotes better circulation and overall heart health.
  • Crafted from healthy bacteria and soybeans, this product contains blood-flow friendly enzymes, making it suitable for those adhering to a vegan lifestyle.
  • Doctor's Best Nattokinase is manufactured and independently tested at an industry-recognized facility, ensuring the highest quality standards are met.


  • While encapsulated for ease of consumption, some individuals may find the taste or texture of natto unappealing.
  • Depending on individual needs, users may need to take multiple capsules daily to achieve desired effects.
  • As with any supplement, some users may experience mild side effects. It's essential to monitor any adverse reactions and consult with a healthcare professional if necessary.
NOW Supplements Nattokinase

NOW Supplements Nattokinase 100 mg offers a potent solution for supporting cardiovascular health. Derived from non-GMO soy and containing 2,000 FUs (Fibrinolytic Units) per 100 mg serving, this supplement aims to maintain normal blood flow and promote heart health.

NOW Nattokinase strives to uphold these traditions by delivering a quality product that meets modern standards of purity and efficacy.


  • Derived from non-GMO soy and free from common allergens like wheat, gluten, milk, egg, fish, shellfish, tree nut, or sesame ingredients.
  • Each serving provides 2,000 FUs of Nattokinase, supporting cardiovascular health and normal blood clotting functions.
  • The supplement is vegan and keto-friendly, catering to a wide range of dietary preferences and lifestyles.
  • Manufactured in a GMP facility with rigorous quality control measures, ensuring the potency and safety of each capsule.
  • NOW's longstanding reputation backs the product for providing clean, effective, and trustworthy supplements.


  • Some individuals may experience mild side effects or interactions, especially those with pre-existing blood coagulation disorders or those taking anti-coagulant medications, requiring consultation with a healthcare professional before use.
  • The capsule form may not be suitable for everyone's preferences, as some individuals may prefer alternative delivery methods such as tablets or liquid formulations.
Nutricost Nattokinase 2,000FU

Nutricost Nattokinase 2,000FU provides a potent solution for supporting healthy circulation with each capsule containing 2,000FU of nattokinase. Crafted by Nutricost, a brand committed to quality and purity, this supplement is designed to promote optimal blood flow and circulation, encapsulated in a gluten-free, vegetarian-friendly form.


  • Each serving delivers a significant dose of 2,000FU of nattokinase, offering robust support for circulation and cardiovascular health.
  • The 120-capsule bottle provides a generous supply, ensuring convenience and continuity in usage.
  • Nutricost prioritizes quality and safety, with the supplement being non-GMO, gluten-free, and vegetarian-friendly, catering to diverse dietary preferences and restrictions.
  • Third-party testing by ISO-accredited laboratories enhances confidence in the product's purity and efficacy, reassuring users of its reliability.
  • The capsules are compact and easy to swallow, facilitating hassle-free consumption for individuals of all ages.


  • Some users may prefer alternative forms of supplementation, such as gel tablets, for potentially better absorption.
  • As with any dietary supplement, consult a healthcare professional before use, especially if pregnant, nursing, or under medical supervision.
Best Naturals Nattokinase

Best Naturals Nattokinase provides a convenient and vegetarian-friendly supplement option for individuals seeking to support their cardiovascular health. Each capsule contains 100 mg of Nattokinase and boasts 2000 FU (Fibrinolytic Units), this product is designed to aid in maintaining a healthy circulatory system.

Manufactured in the USA in a GMP-compliant and FDA-registered facility, it undergoes third-party lab testing to ensure purity and quality, aligning with Best Naturals' commitment to delivering reliable supplements.


  • Each capsule contains 100 mg of Nattokinase, offering a potent dosage to support cardiovascular health.
  • The product is vegetarian-friendly, encapsulated in vegetarian capsules, catering to diverse dietary preferences.
  • Best Naturals prioritizes quality assurance by subjecting the supplement to third-party lab testing, ensuring its purity and efficacy.
  • It is free from common allergens such as gluten, GMOs, artificial colors, flavors, and preservatives, making it suitable for individuals with sensitivities.
  • Manufactured in the USA under stringent GMP guidelines, the supplement meets regulatory standards for safety and quality, reassuring consumers.


  • Some users may find the recommended serving suggestion of one capsule 1 or 2 times daily on an empty stomach inconvenient or difficult to adhere to.
  • While generally well-tolerated, a few individuals may experience mild side effects such as dizziness or gastrointestinal discomfort, although these occurrences appear infrequent.
  • While the product is designed to support cardiovascular health, individuals with pre-existing medical conditions or those taking medication should consult a healthcare professional before incorporating it into their regimen.
Source Naturals NSK-SD Nattokinase

Source Naturals NSK-SD Nattokinase provides a systemic enzyme solution for individuals seeking to maintain healthy circulation. This supplement is formulated to support optimal blood flow by assisting the body's circulatory clearing system. Each vegan capsule contains 100mg of Nattokinase, offering a convenient and effective means of promoting circulatory health.


  • Source Naturals has a longstanding reputation for producing high-quality supplements, backed by over 35 years of experience in the industry.
  • The suggested use of one capsule three times daily on an empty stomach with water ensures ease of consumption and absorption.
  • This product is free from common allergens such as yeast, dairy, egg, gluten, and wheat, making it suitable for individuals with dietary sensitivities.
  • Source Naturals prioritizes manufacturing in the USA, ensuring adherence to strict quality control standards and regulations.
  • Nattokinase has been studied for its potential benefits in supporting cardiovascular health, making it a valuable addition to an adult wellness routine.


  • Some users may need help remembering the dosage regimen of three capsules daily.
  • The product contains soy, which may concern individuals with soy allergies or sensitivities.
SOLARAY Nattokinase Serrapeptase Supplement

SOLARAY Nattokinase Serrapeptase Supplement offers comprehensive support for circulation, cardiovascular health, and sinus maintenance. Nattokinase has been utilized to promote healthy blood flow and cardiovascular function. Additionally, with an added 30 mg of serrapeptase, this supplement aims to support sinus health.

The enteric-coated capsules ensure the ingredients survive stomach acid, allowing for better utilization in the small intestine. This feature enhances the supplement's effectiveness. Furthermore, Solaray prioritizes eco-friendly practices by utilizing 100% PCR bottles made from plastic removed from oceans and landfills.


  • Comprehensive support for circulation and cardiovascular health.
  • Includes serrapeptase to support sinus health.
  • Enteric-coated capsules ensure better ingredient utilization by surviving stomach acid.
  • Eco-friendly packaging with 100% PCR bottles.
  • Made in a GMP-certified facility and tested in a state-of-the-art lab in Utah, ensuring high-quality standards.
  • Backed by a 60-Day Money-Back Guarantee, providing assurance to customers.


  • Limited to 30 servings per container, which may require frequent repurchasing for long-term use.
  • Some users may experience mild side effects, such as heartburn, especially if taken on an empty stomach.
  • Not suitable for individuals taking anticoagulant medications or those with conditions associated with bleeding, due to the nature of the ingredients.
Allergy Research Group Nattokinase Supplement NSK-SD 2000 FU

The Allergy Research Group Nattokinase Supplement NSK-SD 2000 FU offers a potent solution for cardiovascular and circulatory health through its 100mg softgel capsules. As the pioneer of Nattokinase introduction into the US market, Allergy Research Group has set the standard for quality and potency, supported by comprehensive safety studies. Each softgel contains 100mg of isolated and purified Nattokinase NSK-SD, providing 2000 FU (Fibrinolytic Units) per dose.


  • Allergy Research Group maintains a reputation for sourcing only the purest raw materials, ensuring high-quality supplements.
  • With 100mg of Nattokinase NSK-SD per softgel, it offers a potent and standardized dose for cardiovascular and circulatory support.
  • Suitable for adults, the suggested use of one softgel twice daily, with or without food, offers convenient dosing.
  • Allergy Research Group supplements are doctor-developed and hypoallergenic, catering to individuals with specific sensitivities.
  • The product is part of a range of professional-grade supplements, reflecting the company's commitment to health and well-being.


  • While softgel form offers easy ingestion for most users, some individuals may prefer alternative forms such as capsules.
  • Those requiring higher doses of Nattokinase may need to take multiple softgels, potentially increasing the overall cost.
Healthy Origins Nattokinase 2,000 FUs

Healthy Origins Nattokinase 2,000 FUs, 100 mg is a premium supplement derived from the traditional Japanese food natto, known for its health benefits. As a vegan, non-GMO, and gluten-free product, it caters to a wide range of dietary preferences and restrictions. With each capsule containing 2,000 FUs of nattokinase, it supports healthy blood flow and circulatory health, contributing to overall wellness.


  • Extracted from non-GMO soybeans and fermented with Bacillus natto, this supplement is free from genetically modified organisms and soy, catering to individuals with specific dietary preferences.
  • With a history dating back to 1996, Healthy Origins has built a reputation for using premium ingredients to create effective dietary supplements.
  • The product features sustainability features recognized by trusted certifications, including packaging efficiency, contributing to environmental conservation efforts.


  • As with any supplement, it's essential to consult with a healthcare professional before use, especially for individuals who are pregnant, nursing, taking medication, or have underlying medical conditions.

Final Words

After thoroughly reviewing the top 8 nattokinase supplements for cardiovascular health, one product stood out: Doctor's Best Nattokinase. This supplement distinguishes itself from the competition due to its high-quality, vegan-friendly formula derived from non-GMO soybeans and friendly Bacillus subtilis bacteria. Doctor's Best Nattokinase is meticulously crafted to support a healthy circulatory system by maintaining normal fibrinogen levels in the blood, thus promoting optimal blood flow.

Its commitment to quality and safety sets Doctor's Best Nattokinase apart. The product is manufactured and independently tested at an industry-recognized facility, ensuring it meets the highest standards. Moreover, clinical and non-clinical studies have demonstrated nattokinase's ability to contribute to heart and circulatory health by maintaining normal blood flow. By choosing Doctor's Best Nattokinase, you can trust that you are investing in a superior supplement backed by science and stringent quality control measures.

Frequently Asked Questions

Can nattokinase lower blood pressure?

Yes, nattokinase has been shown to help lower blood pressure. Studies suggest a 2,000 FU/day dosage of nattokinase can reduce systolic and diastolic blood pressure in hypertensive subjects over eight weeks​.

Does nattokinase interact with blood thinners like Warfarin?

Nattokinase can be taken with Warfarin without adverse effects, and it might even enhance the effectiveness of the blood thinner. However, due to the risk of excessive bleeding, it's crucial to consult with a healthcare provider before combining nattokinase with any blood thinners.​

Who should avoid taking nattokinase?

Individuals taking blood pressure or blood-thinning medications or those with a soy allergy should consult their doctor before taking nattokinase due to potential drug-nutrient interactions and allergic reactions​.

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Clinical Physician Assistant, Summit Health
Jeff brings to Buoy 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medicine....
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