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Depression Treatment Overview

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Care Plan


First steps to consider

  • It’s important to see a healthcare provider, either your primary care provider, or a behavioral health provider (psychologist, social worker) to get a diagnosis and discuss a treatment plan.
  • Depression is often best treated with a combination of therapy, lifestyle changes, and antidepressant medication.
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All treatments for depression
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When you may need to see a healthcare provider

It is important to see a healthcare provider if you feel depressed or have a low mood that is lasting for about 2 weeks. Depression can quickly start interfering with your ability to live your life—it is important to see your healthcare provider before it gets worse.

Depression can come in different forms and has different risk factors and causes. A healthcare provider can help you understand the type and severity of depression you may have or any underlying conditions that may be contributing to it. You can then work with the provider to create a treatment plan, which usually includes therapy, often medications like antidepressants, and lifestyle changes.

Getting diagnosed

Your primary care provider or a mental health provider can do a simple depression screening to diagnose depression. But to understand your depression better, a provider may ask you to fill out a self-report depression-screening tool, ask you additional questions about your symptoms and different areas of your life, and will use established criteria to assess you for depression. They may do a physical exam and order blood tests if they are concerned about physical causes of depression like low thyroid hormone.

What to expect from your visit

With all depressive disorders, the treatment recommendation will likely include psychotherapy, medication, and lifestyle changes.

  • Therapy with a behavioral health provider (psychologist, social worker) helps to understand and change depressive patterns in thinking, feeling, and behaving. You will be asked to practice at home replacing negative beliefs and behaviors with more positive ones, and using other strategies related to communication, stress regulation, and coping.
  • Cognitive behavioral therapy (CBT) is the most common therapy. This approach helps you change negative patterns of thinking, feeling, and behaving. It may also include mind-body approaches to focus on relaxation and coping strategies.
  • Other approaches that therapists may use include acceptance and commitment therapy (ACT), dialectical behavior therapy (DBT), and psychodynamic therapy.
  • Depression medications. Most commonly prescribed antidepressants are SSRIs, SNRIs, atypical antidepressant medications, or tricyclics. Most antidepressant medications take approximately 4-6 weeks to reach their full therapeutic effect, but you may start to feel some effects after a few days to a couple of weeks. All medications can have side effects, and it’s important to discuss them with your provider to find the medication that offers the best results and least side effects for you.
  • Brain stimulation therapies for treatment-resistant depression. Some people with severe depression who have tried multiple medications but haven’t been able to treat their depression may consider deep brain stimulation therapies. These include repetitive transcranial magnetic stimulation (rTMS), electroconvulsive therapy (ECT or “shock therapy”), vagus nerve stimulation, and transcranial direct current stimulation (tDCS). Discuss these options with your medical provider.
  • Other treatment options: alternative drug therapies. There is growing research and support for the use of other drugs in the treatment of depression. Some of these are still considered experimental, like MDMA, but a few have been FDA approved, like nasal ketamine, an anesthetic. Before you try any of these, discuss it with your healthcare provider to make sure they’re safe for you.

Prescription depression medications

Selective serotonin reuptake inhibitors (SSRIs)

  • Citalopram (Celexa)
  • Fluoxetine (Prozac)
  • Escitalopram (Lexapro)
  • Sertraline (Zoloft)

Serotonin norepinephrine reuptake inhibitors (SNRI’s)

  • Duloxetine (Cymbalta)
  • Venlafaxine (Effexor)

Atypical antidepressants

  • Bupropion (Wellbutrin)
  • Mirtazapine (Remeron)

Tricyclic antidepressants

  • Amitriptyline (Elavil)
  • Nortriptyline (Pamelor)

Types of providers

  • A primary care provider can diagnose and refer your to mental health services and may prescribe antidepressant medication
  • Psychiatrists can diagnose you and prescribe antidepressant medication.
  • Mental health providers, such as a psychologist, social worker, or mental health counselor, can offer therapy.
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